hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13522.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HBA1 | Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin] | 5 | UniProt NCBI |
| SLC9A5 | Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5) | 5 | UniProt NCBI |
| UPF3A | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | 5 | UniProt NCBI |
| BMP5 | Bone morphogenetic protein 5 (BMP-5) | 5 | UniProt NCBI |
| LPAR6 | Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5) (RB intron encoded G-protein coupled receptor) | 5 | UniProt NCBI |
| HMGCLL1 | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (EC 4.1.3.4) (3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1) (HMGCL-like 1) (Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase) (er-cHL) | 5 | UniProt NCBI |
| CA1 | Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I) (Cyanamide hydratase CA1) (EC 4.2.1.69) | 5 | UniProt NCBI |
| HP | Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] | 5 | UniProt NCBI |
| PLSCR4 | Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1) | 5 | UniProt NCBI |
| HBB | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1247673 | 0.00167485737707 | 0.222222222222 | CA1 HBB | Erythrocytes take up oxygen and release carbon dioxide |
| REAC:R-HSA-1237044 | 0.00286935042585 | 0.222222222222 | CA1 HBB | Erythrocytes take up carbon dioxide and release oxygen |
| REAC:R-HSA-1480926 | 0.00286935042585 | 0.222222222222 | CA1 HBB | O2/CO2 exchange in erythrocytes |
| REAC:R-HSA-2168880 | 0.00525543712779 | 0.222222222222 | HP HBB | Scavenging of heme from plasma |
| REAC:R-HSA-2173782 | 0.0470317013402 | 0.222222222222 | HP HBB | Binding and Uptake of Ligands by Scavenger Receptors |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HBA1 | HBB | 0.997 | 0.462 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| CA1 | UPF3A | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HBB | UPF3A | 0.984 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PLSCR4 | HP | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HBA1 | UPF3A | 0.975 | 0.0631613599568 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| HBB | HMGCLL1 | 0.959 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LPAR6 | HBA1 | 0.956 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HBA1 | HMGCLL1 | 0.955 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HP | HMGCLL1 | 0.945 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC9A5 | HBB | 0.932 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HP | HBA1 | 0.891 | 0.316 | bioplex_WMM bioplex3_WMM WMM_only |
| HBB | BMP5 | 0.886 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LPAR6 | HBB | 0.877 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HP | HBB | 0.86 | 0.388 | bioplex_WMM bioplex3_WMM WMM_only |
| HBA1 | BMP5 | 0.398 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HBB | CA1 | 0.169 | 0.188 | bioplex_WMM bioplex3_WMM WMM_only |
| HBA1 | CA1 | 0.16 | 0.448 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes