hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13541.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
LHX1	LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1)	5	UniProt NCBI
LMX1B	LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B)	5	UniProt NCBI
BCL9	B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog)	5	UniProt NCBI
LHX3	LIM/homeobox protein Lhx3 (LIM homeobox protein 3)	5	UniProt NCBI
SSBP3	Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein)	5	UniProt NCBI
LHX9	LIM/homeobox protein Lhx9 (LIM homeobox protein 9)	5	UniProt NCBI
CLEC18A	C-type lectin domain family 18 member A (Mannose receptor-like protein 2)	5	UniProt NCBI
LMO3	LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3)	5	UniProt NCBI
ISL1	Insulin gene enhancer protein ISL-1 (Islet-1)	5	UniProt NCBI
LHX2	LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)	5	UniProt NCBI
LDB1	LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)	5	UniProt NCBI
LHX4	LIM/homeobox protein Lhx4 (LIM homeobox protein 4)	5	UniProt NCBI
MN1	Transcriptional activator MN1 (Probable tumor suppressor protein MN1)	5	UniProt NCBI
LMO4	LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)	5	UniProt NCBI
IDI2	Isopentenyl-diphosphate delta-isomerase 2 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 2) (IPP isomerase 2) (IPPI2)	5	UniProt NCBI
SSBP4	Single-stranded DNA-binding protein 4	3	UniProt NCBI
SSBP2	Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2)	4	UniProt NCBI
ISL2	Insulin gene enhancer protein ISL-2 (Islet-2)	4	UniProt NCBI
LMO1	Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM domain only protein 1) (LMO-1) (T-cell translocation protein 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9010553	1.00375305028e-05	0.333333333333	LHX4 ISL1 LHX9 LHX3 LDB1 LHX2	Regulation of expression of SLITs and ROBOs
GO:0045893	1.11435997999e-05	0.666666666667	LHX4 BCL9 LMX1B LHX3 SSBP2 LDB1 ISL2 LHX1 LHX2 SSBP3 SSBP4 ISL1	positive regulation of DNA-templated transcription
GO:1902680	1.1519420388e-05	0.666666666667	LHX4 BCL9 LMX1B LHX3 SSBP2 LDB1 ISL2 LHX1 LHX2 SSBP3 SSBP4 ISL1	positive regulation of RNA biosynthetic process
REAC:R-HSA-376176	4.06549570823e-05	0.333333333333	LHX4 ISL1 LHX9 LHX3 LDB1 LHX2	Signaling by ROBO receptors
GO:0051254	4.18853657851e-05	0.666666666667	LHX4 BCL9 LMX1B LHX3 SSBP2 LDB1 ISL2 LHX1 LHX2 SSBP3 SSBP4 ISL1	positive regulation of RNA metabolic process
GO:0006357	0.000191228395	0.722222222222	LHX4 BCL9 LDB1 LHX3 ISL1 SSBP2 LHX9 ISL2 LHX1 LHX2 SSBP3 SSBP4 LMX1B	regulation of transcription by RNA polymerase II
GO:0045935	0.000193303158699	0.666666666667	LHX4 BCL9 LMX1B LHX3 SSBP2 LDB1 ISL2 LHX1 LHX2 SSBP3 SSBP4 ISL1	positive regulation of nucleobase-containing compound metabolic process
GO:0045944	0.000206687073483	0.555555555556	LHX4 ISL1 ISL2 BCL9 LHX3 SSBP2 LDB1 SSBP3 SSBP4 LMX1B	positive regulation of transcription by RNA polymerase II
CORUM:2214	0.000346113734644	0.111111111111	LDB1 LMO4	LMO4-BRCA1-CTIP-LDB1 complex
GO:0006366	0.000370336291578	0.722222222222	LHX4 BCL9 LDB1 LHX3 ISL1 SSBP2 LHX9 ISL2 LHX1 LHX2 SSBP3 SSBP4 LMX1B	transcription by RNA polymerase II
GO:0010557	0.00227229167076	0.666666666667	LHX4 BCL9 LMX1B LHX3 SSBP2 LDB1 ISL2 LHX1 LHX2 SSBP3 SSBP4 ISL1	positive regulation of macromolecule biosynthetic process
GO:0031328	0.00317410148622	0.666666666667	LHX4 BCL9 LMX1B LHX3 SSBP2 LDB1 ISL2 LHX1 LHX2 SSBP3 SSBP4 ISL1	positive regulation of cellular biosynthetic process
GO:0030182	0.00323963619286	0.5	LHX4 ISL1 LDB1 LHX3 LHX9 ISL2 LHX1 LHX2 LMX1B	neuron differentiation
GO:0009891	0.00341150762554	0.666666666667	LHX4 BCL9 LMX1B LHX3 SSBP2 LDB1 ISL2 LHX1 LHX2 SSBP3 SSBP4 ISL1	positive regulation of biosynthetic process
REAC:R-HSA-422475	0.00509716776322	0.333333333333	LHX4 ISL1 LHX9 LHX3 LDB1 LHX2	Axon guidance
GO:0048699	0.00522053807214	0.5	LHX4 ISL1 LDB1 LHX3 LHX9 ISL2 LHX1 LHX2 LMX1B	generation of neurons
GO:0031325	0.00545198459409	0.722222222222	LHX4 BCL9 LMX1B LHX3 LMO4 SSBP2 LDB1 ISL2 LHX1 LHX2 SSBP3 SSBP4 ISL1	positive regulation of cellular metabolic process
REAC:R-HSA-9675108	0.00627668274214	0.333333333333	LHX4 ISL1 LHX9 LHX3 LDB1 LHX2	Nervous system development
GO:0006355	0.00727402217881	0.722222222222	LHX4 BCL9 LDB1 LHX3 ISL1 SSBP2 LHX9 ISL2 LHX1 LHX2 SSBP3 SSBP4 LMX1B	regulation of DNA-templated transcription
GO:2001141	0.00782927103283	0.722222222222	LHX4 BCL9 LDB1 LHX3 ISL1 SSBP2 LHX9 ISL2 LHX1 LHX2 SSBP3 SSBP4 LMX1B	regulation of RNA biosynthetic process
WP:WP2064	0.011380141833	0.166666666667	LHX2 LHX1 ISL1	Neural crest differentiation
GO:0006351	0.0129316125027	0.722222222222	LHX4 BCL9 LDB1 LHX3 ISL1 SSBP2 LHX9 ISL2 LHX1 LHX2 SSBP3 SSBP4 LMX1B	DNA-templated transcription
GO:0032774	0.0147184153767	0.722222222222	LHX4 BCL9 LDB1 LHX3 ISL1 SSBP2 LHX9 ISL2 LHX1 LHX2 SSBP3 SSBP4 LMX1B	RNA biosynthetic process
GO:0022008	0.0166407603463	0.5	LHX4 ISL1 LDB1 LHX3 LHX9 ISL2 LHX1 LHX2 LMX1B	neurogenesis
GO:0009893	0.0232148273888	0.722222222222	LHX4 BCL9 LMX1B LHX3 LMO4 SSBP2 LDB1 ISL2 LHX1 LHX2 SSBP3 SSBP4 ISL1	positive regulation of metabolic process
GO:0051173	0.0234385014391	0.666666666667	LHX4 BCL9 LMX1B LHX3 SSBP2 LDB1 ISL2 LHX1 LHX2 SSBP3 SSBP4 ISL1	positive regulation of nitrogen compound metabolic process
HP:0000839	0.0261313881914	0.111111111111	LHX3 LHX4	Pituitary dwarfism
HP:0031218	0.0261313881914	0.111111111111	LHX3 LHX4	Inappropriate antidiuretic hormone secretion
GO:0051252	0.0281570902683	0.722222222222	LHX4 BCL9 LDB1 LHX3 ISL1 SSBP2 LHX9 ISL2 LHX1 LHX2 SSBP3 SSBP4 LMX1B	regulation of RNA metabolic process
GO:0000785	0.0345152792811	0.5	LHX4 ISL1 LDB1 LHX3 LHX9 ISL2 LHX1 LHX2 LMX1B	chromatin
GO:0048522	0.0364294175862	0.833333333333	MN1 LHX4 BCL9 LDB1 LHX3 ISL1 LMO4 SSBP2 LMO3 ISL2 LHX1 LHX2 SSBP3 SSBP4 LMX1B	positive regulation of cellular process
GO:0007399	0.0385865290337	0.555555555556	LHX4 ISL1 LDB1 LHX3 LMO4 LHX9 ISL2 LHX1 LHX2 LMX1B	nervous system development
HP:0031221	0.0487074188602	0.111111111111	LHX3 LHX4	Abnormal radioactive iodine uptake test result
HP:0031219	0.0487074188602	0.111111111111	LHX3 LHX4	Reduced radioactive iodine uptake
CORUM:3181	0.0496617483143	0.0555555555556	LMO4	LMO4-CREB complex

Edges

Protein 1	Protein 2	Score	ProteomeHD
LMO4	SSBP4	1.0	0.054
LMO4	SSBP3	1.0	0.0933333333333
SSBP2	LMO4	1.0	0.076
LMX1B	SSBP4	1.0
SSBP4	ISL2	1.0
LDB1	SSBP4	1.0
LDB1	SSBP3	1.0
SSBP2	LMX1B	1.0
ISL2	SSBP3	1.0
SSBP2	SSBP3	1.0	0.098
SSBP2	SSBP4	1.0	0.088
SSBP4	ISL1	0.999
SSBP2	ISL2	0.999
LDB1	SSBP2	0.999
SSBP4	LMO1	0.999
ISL1	SSBP3	0.999
LMX1B	SSBP3	0.999
SSBP4	SSBP3	0.999	0.154
LDB1	LMX1B	0.999
LHX2	SSBP3	0.999
SSBP2	ISL1	0.998
LMX1B	ISL2	0.998
LDB1	ISL2	0.998
LMO3	SSBP4	0.998
LMO3	LDB1	0.997
LDB1	LMO1	0.997
LMO1	SSBP3	0.997
SSBP2	LMO1	0.997
LMO3	SSBP2	0.996
LMO3	SSBP3	0.996
LHX4	SSBP4	0.995
LHX3	SSBP3	0.994
LDB1	LMO4	0.994
LMO4	LMX1B	0.993
LMO4	ISL2	0.993
SSBP2	CLEC18A	0.993
LDB1	LHX4	0.992
LDB1	ISL1	0.992
ISL2	ISL1	0.992
LMO3	LMX1B	0.991
LHX4	SSBP3	0.988
LMO4	LMO1	0.987
LMO4	ISL1	0.984
LHX3	LDB1	0.984
LHX1	SSBP4	0.984
LMX1B	ISL1	0.983
SSBP4	LHX9	0.982
IDI2	SSBP3	0.977
LMO3	LHX4	0.976
ISL2	LMO1	0.975
SSBP4	LHX2	0.975
LMO3	ISL2	0.974
LMO4	IDI2	0.974
LHX9	SSBP3	0.973
LDB1	LHX9	0.972
SSBP2	IDI2	0.972
MN1	LMO3	0.971
LHX1	SSBP3	0.969
IDI2	SSBP4	0.963
LDB1	IDI2	0.961
LHX3	ISL2	0.956
ISL2	BCL9	0.944
SSBP2	LHX4	0.94
LMX1B	LMO1	0.934
MN1	LMO1	0.926
LHX3	SSBP4	0.924
LMO4	CLEC18A	0.924
LHX3	SSBP2	0.916
LMO3	ISL1	0.905
LMX1B	IDI2	0.904
LHX2	LMO1	0.892
ISL2	CLEC18A	0.862
LMX1B	CLEC18A	0.862
LMO4	LHX2	0.855
ISL2	LHX2	0.838
LMX1B	LHX2	0.838
ISL1	LHX2	0.826
SSBP2	LHX2	0.803
LDB1	LHX2	0.791
LHX4	ISL1	0.778
LHX4	ISL2	0.773
SSBP3	CLEC18A	0.767
SSBP4	CLEC18A	0.748
LDB1	CLEC18A	0.738
ISL1	LMO1	0.73
MN1	LDB1	0.607
MN1	SSBP3	0.607
MN1	SSBP4	0.607
MN1	SSBP2	0.607
LHX1	LMO4	0.575
LHX4	LMX1B	0.569
LHX1	LHX2	0.465
LMO4	BCL9	0.415	0.138
IDI2	ISL2	0.402
LHX4	LMO4	0.4
LDB1	LHX1	0.4
SSBP2	LHX1	0.4
LHX1	ISL2	0.4
LHX1	LMX1B	0.4
LHX4	CLEC18A	0.396
LHX4	LHX1	0.396
MN1	ISL2	0.392
ISL1	CLEC18A	0.378
LHX1	ISL1	0.367
LHX1	LMO1	0.333
LMX1B	BCL9	0.274
SSBP2	BCL9	0.25	0.09
SSBP3	BCL9	0.238	0.158
LDB1	BCL9	0.21
SSBP4	BCL9	0.21	0.098
LHX4	LMO1	0.164
LHX4	LHX2	0.146
MN1	LHX4	0.113
MN1	ISL1	0.095
MN1	LMX1B	0.072
MN1	LMO4	0.046

Related Complexes

Genename	Complexes
LHX1	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LMX1B	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
BCL9	huMAP3_13541.1
LHX3	huMAP3_01557.1 huMAP3_02691.1 huMAP3_06128.1 huMAP3_09723.1 huMAP3_13541.1
SSBP3	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX9	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
CLEC18A	huMAP3_13541.1
LMO3	huMAP3_01733.1 huMAP3_04791.1 huMAP3_09723.1 huMAP3_11722.1 huMAP3_13541.1 huMAP3_14094.1 huMAP3_14991.1
ISL1	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LDB1	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX4	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
MN1	huMAP3_01733.1 huMAP3_04419.1 huMAP3_07979.1 huMAP3_11722.1 huMAP3_13541.1 huMAP3_14006.1 huMAP3_14094.1 huMAP3_14640.1 huMAP3_14991.1
LMO4	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
IDI2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
SSBP4	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
SSBP2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
ISL2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LMO1	huMAP3_02691.1 huMAP3_03114.1 huMAP3_09723.1 huMAP3_11722.1 huMAP3_13541.1 huMAP3_14006.1 huMAP3_14094.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13541.1