hu.MAP 3.0: Complex View

Genename	Protein Name	Uniprot Annotation Score	Links
CTSG	Cathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G, C-terminal truncated form]	5	UniProt NCBI
APCDD1	Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein)	5	UniProt NCBI
SPATA17	Spermatogenesis-associated protein 17	3	UniProt NCBI
SMIM8	Small integral membrane protein 8	2	UniProt NCBI
ELANE	Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)	5	UniProt NCBI
MPO	Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]	5	UniProt NCBI
MNDA	Myeloid cell nuclear differentiation antigen	5	UniProt NCBI
LRRC17	Leucine-rich repeat-containing protein 17 (p37NB)	3	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04613	0.0027731634577	0.375	MPO CTSG ELANE	Neutrophil extracellular trap formation
GO:0035578	0.00402583472149	0.5	MPO MNDA CTSG ELANE	azurophil granule lumen
REAC:R-HSA-6798695	0.00992836955601	0.5	MPO MNDA CTSG ELANE	Neutrophil degranulation
REAC:R-HSA-1592389	0.0153043597228	0.25	CTSG ELANE	Activation of Matrix Metalloproteinases
GO:0005766	0.0315462658883	0.5	MPO MNDA CTSG ELANE	primary lysosome
GO:0042582	0.0315462658883	0.5	MPO MNDA CTSG ELANE	azurophil granule
WP:WP5356	0.0376097283422	0.25	MPO ELANE	Affected pathways in Duchenne muscular dystrophy
GO:0005775	0.0433830596151	0.5	MPO MNDA CTSG ELANE	vacuolar lumen

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
LRRC17	ELANE	0.992			bioplex3_WMM bioplex3_HCT116 WMM_only
SMIM8	MNDA	0.99		mutually_exclusive (P24158)	bioplex3_WMM bioplex3_HCT116 WMM_only
CTSG	LRRC17	0.984			bioplex3_WMM bioplex3_HCT116 WMM_only
ELANE	SMIM8	0.977			bioplex3_WMM bioplex3_HCT116 WMM_only
MPO	LRRC17	0.974			bioplex3_WMM bioplex3_HCT116 WMM_only
CTSG	SMIM8	0.962		mutually_exclusive (P24158)	bioplex3_WMM bioplex3_HCT116 WMM_only
MPO	CTSG	0.956	0.328		bioplex_WMM bioplex3_WMM WMM_only treiber_WMM
MPO	SMIM8	0.953			bioplex3_WMM bioplex3_HCT116 WMM_only
ELANE	SPATA17	0.948			bioplex3_HEK293 bioplex3_WMM WMM_only
CTSG	APCDD1	0.889			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CTSG	ELANE	0.868	0.254	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM WMM_only treiber_WMM
MPO	ELANE	0.868	0.304		bioplex_WMM bioplex3_WMM WMM_only treiber_WMM
ELANE	MNDA	0.805	0.242	structurally_consistent (dimer)	bioplex3_WMM WMM_only
MPO	MNDA	0.805	0.328		bioplex3_WMM WMM_only
CTSG	MNDA	0.805	0.354	structurally_consistent (dimer)	bioplex3_WMM WMM_only
MPO	APCDD1	0.689			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM

Genename	Complexes
CTSG	huMAP3_03846.1 huMAP3_10260.1 huMAP3_11343.1 huMAP3_13546.1
APCDD1	huMAP3_11343.1 huMAP3_13546.1
SPATA17	huMAP3_13546.1
SMIM8	huMAP3_07991.1 huMAP3_09846.1 huMAP3_10260.1 huMAP3_11343.1 huMAP3_13546.1
ELANE	huMAP3_07914.1 huMAP3_10260.1 huMAP3_11343.1 huMAP3_13546.1
MPO	huMAP3_03846.1 huMAP3_10260.1 huMAP3_11343.1 huMAP3_13546.1
MNDA	huMAP3_10260.1 huMAP3_11343.1 huMAP3_13546.1
LRRC17	huMAP3_06925.1 huMAP3_07914.1 huMAP3_08575.1 huMAP3_09268.1 huMAP3_09449.1 huMAP3_10444.1 huMAP3_13546.1