hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13546.1
Complex Portal: CPX-24734
Confidence: Medium  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
CTSG | Cathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G, C-terminal truncated form] | 5 | UniProt   NCBI |
APCDD1 | Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein) | 5 | UniProt   NCBI |
SPATA17 | Spermatogenesis-associated protein 17 | 3 | UniProt   NCBI |
SMIM8 | Small integral membrane protein 8 | 2 | UniProt   NCBI |
ELANE | Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase) | 5 | UniProt   NCBI |
MPO | Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] | 5 | UniProt   NCBI |
MNDA | Myeloid cell nuclear differentiation antigen | 5 | UniProt   NCBI |
LRRC17 | Leucine-rich repeat-containing protein 17 (p37NB) | 3 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  KEGG:04613 | 0.0027731634577 | 0.375 | CTSG ELANE MPO | Neutrophil extracellular trap formation |
  GO:0035578 | 0.00402583472149 | 0.5 | CTSG MNDA ELANE MPO | azurophil granule lumen |
  REAC:R-HSA-6798695 | 0.00992836955601 | 0.5 | CTSG MNDA ELANE MPO | Neutrophil degranulation |
  REAC:R-HSA-1592389 | 0.0153043597228 | 0.25 | CTSG ELANE | Activation of Matrix Metalloproteinases |
  GO:0005766 | 0.0315462658883 | 0.5 | CTSG MNDA ELANE MPO | primary lysosome |
  GO:0042582 | 0.0315462658883 | 0.5 | CTSG MNDA ELANE MPO | azurophil granule |
  WP:WP5356 | 0.0376097283422 | 0.25 | MPO ELANE | Affected pathways in Duchenne muscular dystrophy |
  GO:0005775 | 0.0433830596151 | 0.5 | CTSG MNDA ELANE MPO | vacuolar lumen |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
---|---|---|---|---|---|
 LRRC17 |  ELANE | 0.992 |            |          | bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 SMIM8 |  MNDA | 0.99 |            |
mutually_exclusive (P24158)        
|
bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 CTSG |  LRRC17 | 0.984 |            |          | bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 ELANE |  SMIM8 | 0.977 |            |          | bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 MPO |  LRRC17 | 0.974 |            |          | bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 CTSG |  SMIM8 | 0.962 |            |
mutually_exclusive (P24158)        
|
bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 MPO |  CTSG | 0.956 | 0.328           |          | bioplex_WMM     bioplex3_WMM     WMM_only     treiber_WMM     |
 MPO |  SMIM8 | 0.953 |            |          | bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 ELANE |  SPATA17 | 0.948 |            |          | bioplex3_HEK293     bioplex3_WMM     WMM_only     |
 CTSG |  APCDD1 | 0.889 |            |          | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     |
 MPO |  ELANE | 0.868 | 0.304           |          | bioplex_WMM     bioplex3_WMM     WMM_only     treiber_WMM     |
 CTSG |  ELANE | 0.868 | 0.254           |
structurally_consistent (dimer)        
|
bioplex_WMM     bioplex3_WMM     WMM_only     treiber_WMM     |
 ELANE |  MNDA | 0.805 | 0.242           |
structurally_consistent (dimer)        
|
bioplex3_WMM     WMM_only     |
 MPO |  MNDA | 0.805 | 0.328           |          | bioplex3_WMM     WMM_only     |
 CTSG |  MNDA | 0.805 | 0.354           |
structurally_consistent (dimer)        
|
bioplex3_WMM     WMM_only     |
 MPO |  APCDD1 | 0.689 |            |          | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     |
Related Complexes