hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13546.1
Complex Portal: CPX-24734
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CTSG | Cathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G, C-terminal truncated form] | 5 | UniProt NCBI |
| APCDD1 | Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein) | 5 | UniProt NCBI |
| SPATA17 | Spermatogenesis-associated protein 17 | 3 | UniProt NCBI |
| SMIM8 | Small integral membrane protein 8 | 2 | UniProt NCBI |
| ELANE | Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase) | 5 | UniProt NCBI |
| MPO | Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] | 5 | UniProt NCBI |
| MNDA | Myeloid cell nuclear differentiation antigen | 5 | UniProt NCBI |
| LRRC17 | Leucine-rich repeat-containing protein 17 (p37NB) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04613 | 0.0027731634577 | 0.375 | CTSG ELANE MPO | Neutrophil extracellular trap formation |
| GO:0035578 | 0.00402583472149 | 0.5 | CTSG MNDA ELANE MPO | azurophil granule lumen |
| REAC:R-HSA-6798695 | 0.00992836955601 | 0.5 | CTSG MNDA ELANE MPO | Neutrophil degranulation |
| REAC:R-HSA-1592389 | 0.0153043597228 | 0.25 | CTSG ELANE | Activation of Matrix Metalloproteinases |
| GO:0005766 | 0.0315462658883 | 0.5 | CTSG MNDA ELANE MPO | primary lysosome |
| GO:0042582 | 0.0315462658883 | 0.5 | CTSG MNDA ELANE MPO | azurophil granule |
| WP:WP5356 | 0.0376097283422 | 0.25 | MPO ELANE | Affected pathways in Duchenne muscular dystrophy |
| GO:0005775 | 0.0433830596151 | 0.5 | CTSG MNDA ELANE MPO | vacuolar lumen |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LRRC17 | ELANE | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SMIM8 | MNDA | 0.99 |
mutually_exclusive (P24158)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CTSG | LRRC17 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ELANE | SMIM8 | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MPO | LRRC17 | 0.974 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CTSG | SMIM8 | 0.962 |
mutually_exclusive (P24158)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MPO | CTSG | 0.956 | 0.328 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| MPO | SMIM8 | 0.953 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ELANE | SPATA17 | 0.948 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CTSG | APCDD1 | 0.889 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MPO | ELANE | 0.868 | 0.304 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| CTSG | ELANE | 0.868 | 0.254 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only treiber_WMM |
| ELANE | MNDA | 0.805 | 0.242 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| MPO | MNDA | 0.805 | 0.328 | bioplex3_WMM WMM_only | |
| CTSG | MNDA | 0.805 | 0.354 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| MPO | APCDD1 | 0.689 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes