hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13548.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KLHL1 | Kelch-like protein 1 | 4 | UniProt NCBI |
| HENMT1 | Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1) | 5 | UniProt NCBI |
| PAMR1 | Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog) | 4 | UniProt NCBI |
| SNX5 | Sorting nexin-5 | 5 | UniProt NCBI |
| SNX6 | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | 5 | UniProt NCBI |
| BMP6 | Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1) | 5 | UniProt NCBI |
| SNX1 | Sorting nexin-1 | 5 | UniProt NCBI |
| HEPACAM | Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM) | 5 | UniProt NCBI |
| SNX2 | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | 5 | UniProt NCBI |
| C1orf87 | Uncharacterized protein C1orf87 | 2 | UniProt NCBI |
| IGFBPL1 | Insulin-like growth factor-binding protein-like 1 (IGFBP-related protein 10) (Insulin-like growth factor-binding-related protein 4) (IGFBP-rP4) | 4 | UniProt NCBI |
| KLHL5 | Kelch-like protein 5 | 4 | UniProt NCBI |
| SNX32 | Sorting nexin-32 (Sorting nexin-6B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030905 | 1.88135311715e-08 | 0.307692307692 | SNX2 SNX5 SNX1 SNX6 | retromer, tubulation complex |
| CORUM:1058 | 4.10333215354e-05 | 0.153846153846 | SNX6 SNX1 | SNX complex (SNX1, SNX6) |
| KEGG:04144 | 6.272611801e-05 | 0.384615384615 | SNX2 SNX32 SNX5 SNX1 SNX6 | Endocytosis |
| GO:0030904 | 7.23839541103e-05 | 0.307692307692 | SNX2 SNX5 SNX1 SNX6 | retromer complex |
| CORUM:1070 | 0.00012303818858 | 0.153846153846 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4) |
| CORUM:1096 | 0.00012303818858 | 0.153846153846 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, PDGFRA) |
| CORUM:1091 | 0.000245952888523 | 0.153846153846 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, LEPR) |
| CORUM:1093 | 0.000245952888523 | 0.153846153846 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, INSR) |
| CORUM:1095 | 0.000245952888523 | 0.153846153846 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, EGFR) |
| GO:0042147 | 0.000345072856334 | 0.384615384615 | SNX2 SNX32 SNX5 SNX1 SNX6 | retrograde transport, endosome to Golgi |
| CORUM:657 | 0.00040971577212 | 0.153846153846 | SNX1 SNX2 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1059 | 0.00040971577212 | 0.153846153846 | SNX1 SNX2 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1060 | 0.00040971577212 | 0.153846153846 | SNX1 SNX2 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) |
| GO:0016482 | 0.00200894089825 | 0.384615384615 | SNX2 SNX32 SNX5 SNX1 SNX6 | cytosolic transport |
| CORUM:1072 | 0.0499717467432 | 0.0769230769231 | SNX2 | SNX complex (SNX2), oligomeric |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SNX5 | SNX1 | 1.0 | 0.326 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SNX6 | SNX1 | 1.0 | 0.562 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SNX1 | SNX2 | 1.0 | 0.378 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| SNX1 | SNX32 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| C1orf87 | SNX5 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| C1orf87 | SNX2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SNX6 | SNX2 | 0.997 | 0.384 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction |
| C1orf87 | SNX1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KLHL1 | KLHL5 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SNX6 | SNX32 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C1orf87 | HEPACAM | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KLHL1 | SNX2 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PAMR1 | SNX1 | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SNX2 | SNX32 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SNX5 | SNX2 | 0.984 | 0.33 | bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction |
| KLHL1 | SNX1 | 0.953 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SNX2 | HENMT1 | 0.928 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SNX5 | IGFBPL1 | 0.919 | 0.048 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| PAMR1 | SNX32 | 0.902 | bioplex3_WMM WMM_only | |
| SNX1 | BMP6 | 0.894 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SNX1 | IGFBPL1 | 0.891 | 0.098 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| SNX2 | BMP6 | 0.875 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KLHL1 | SNX6 | 0.869 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SNX5 | SNX6 | 0.865 | 0.146 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SNX6 | IGFBPL1 | 0.862 | 0.064 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| SNX6 | BMP6 | 0.861 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PAMR1 | SNX5 | 0.86 | bioplex3_WMM WMM_only | |
| SNX6 | HENMT1 | 0.853 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SNX2 | IGFBPL1 | 0.818 | 0.094 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| SNX5 | SNX32 | 0.73 | bioplex_WMM bioplex3_WMM WMM_only | |
| PAMR1 | SNX6 | 0.715 | bioplex3_WMM WMM_only | |
| PAMR1 | SNX2 | 0.356 | bioplex3_WMM WMM_only | |
| HEPACAM | SNX5 | 0.29 | bioplex_WMM bioplex3_WMM WMM_only | |
| KLHL5 | SNX2 | 0.203 | 0.058 | bioplex3_WMM WMM_only |
| HEPACAM | SNX1 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEPACAM | SNX2 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | |
| SNX1 | HENMT1 | 0.142 | bioplex3_HEK293 bioplex () | |
| KLHL5 | SNX1 | 0.055 | 0.07 | bioplex3_WMM WMM_only |
| KLHL5 | SNX6 | 0.042 | 0.088 | bioplex3_WMM WMM_only |
Related Complexes