hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13550.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BRK1 | Protein BRICK1 (BRK1) | 5 | UniProt NCBI |
| NCKAP1L | Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1) | 5 | UniProt NCBI |
| ATG101 | Autophagy-related protein 101 | 5 | UniProt NCBI |
| PPFIA2 | Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) | 5 | UniProt NCBI |
| ULK2 | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) | 5 | UniProt NCBI |
| ULK1 | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | 5 | UniProt NCBI |
| FAM221B | Protein FAM221B | 5 | UniProt NCBI |
| HSBP1 | Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13) | 5 | UniProt NCBI |
| RB1CC1 | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | 5 | UniProt NCBI |
| ATG13 | Autophagy-related protein 13 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6232 | 8.06664600281e-12 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | ULK1-ATG13-RB1CC1-ATG101 complex |
| CORUM:7091 | 8.06664600281e-12 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | FIP200-ULK1-ATG13-ATG101 complex |
| CORUM:7065 | 2.82054434053e-10 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | WDR41-(C9orf72-SMCR8)-(FIP200-ULK1-ATG13-ATG101) complex |
| WP:WP5412 | 1.08524221753e-08 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | 8q11 23 RB1CC1 copy number variation |
| CORUM:6229 | 1.68385473419e-08 | 0.3 | RB1CC1 ULK1 ATG13 | ULK1-ATG13-RB1CC1 complex |
| CORUM:6230 | 1.68385473419e-08 | 0.3 | ULK2 ATG13 RB1CC1 | ULK2-ATG13-RB1CC1 complex |
| WP:WP4863 | 3.31316415231e-08 | 0.4 | ULK2 ATG13 ULK1 RB1CC1 | Host pathogen interaction of human coronaviruses autophagy |
| WP:WP4923 | 2.20961859476e-07 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | Autophagy |
| GO:0000407 | 4.53435749979e-07 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | phagophore assembly site |
| KEGG:05017 | 5.17841113787e-07 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | Spinocerebellar ataxia |
| GO:1990316 | 6.95089238983e-07 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | Atg1/ULK1 kinase complex |
| WP:WP4577 | 9.82375492679e-07 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| GO:1903059 | 1.15810139842e-06 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | regulation of protein lipidation |
| GO:0034727 | 1.15810139842e-06 | 0.4 | ULK2 ATG13 ULK1 RB1CC1 | piecemeal microautophagy of the nucleus |
| KEGG:04140 | 1.57928344798e-06 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | Autophagy - animal |
| GO:0050746 | 3.93917350423e-06 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | regulation of lipoprotein metabolic process |
| GO:0016237 | 7.51529801094e-06 | 0.4 | ULK2 ATG13 ULK1 RB1CC1 | microautophagy |
| GO:0034045 | 7.51529801094e-06 | 0.4 | ULK2 ATG13 ULK1 RB1CC1 | phagophore assembly site membrane |
| WP:WP5205 | 8.67370187686e-06 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | Clock controlled autophagy in bone metabolism |
| KEGG:04211 | 9.02638680743e-06 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | Longevity regulating pathway |
| GO:0044804 | 1.30949840786e-05 | 0.4 | ULK2 ATG13 ULK1 RB1CC1 | nucleophagy |
| WP:WP5124 | 2.19679744334e-05 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | Alzheimer 39 s disease |
| WP:WP2059 | 2.19679744334e-05 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | Alzheimer 39 s disease and miRNA effects |
| KEGG:05016 | 2.48475048984e-05 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | Huntington disease |
| KEGG:04136 | 4.67042578594e-05 | 0.3 | ATG101 ATG13 ULK2 | Autophagy - other |
| KEGG:05014 | 6.01376448746e-05 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 7.62846862374e-05 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | Alzheimer disease |
| WP:WP3844 | 9.1293952863e-05 | 0.3 | RB1CC1 ULK1 ATG13 | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| GO:0000045 | 0.000135135283308 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | autophagosome assembly |
| WP:WP5381 | 0.000159436347169 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| GO:1905037 | 0.000166257674145 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | autophagosome organization |
| CORUM:6816 | 0.000184411585051 | 0.2 | ATG13 ULK1 | ULK1-ATG13-ATG14-PIK3C3 complex |
| KEGG:05022 | 0.000200911474306 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-1632852 | 0.000256657814131 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | Macroautophagy |
| REAC:R-HSA-9612973 | 0.000402564715748 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | Autophagy |
| GO:0010508 | 0.00051421622599 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | positive regulation of autophagy |
| WP:WP5420 | 0.00188783694639 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0007033 | 0.0033034833431 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | vacuole organization |
| GO:0006497 | 0.00366675599097 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | protein lipidation |
| GO:0042158 | 0.00390203518198 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | lipoprotein biosynthetic process |
| WP:WP5087 | 0.0075599887011 | 0.4 | ULK2 ATG13 ULK1 RB1CC1 | Pleural mesothelioma |
| GO:0061709 | 0.00780402634424 | 0.3 | ULK2 ULK1 RB1CC1 | reticulophagy |
| GO:0000422 | 0.00809988459585 | 0.4 | ULK2 ATG13 ULK1 RB1CC1 | autophagy of mitochondrion |
| GO:0042157 | 0.00852338417127 | 0.4 | ATG101 ATG13 ULK1 RB1CC1 | lipoprotein metabolic process |
| WP:WP2509 | 0.00951090854291 | 0.2 | ULK2 ULK1 | Nanoparticle triggered autophagic cell death |
| WP:WP1471 | 0.0229969481751 | 0.2 | ULK2 ULK1 | Target of rapamycin signaling |
| GO:0031331 | 0.02422534277 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | positive regulation of cellular catabolic process |
| GO:0016236 | 0.0255897714314 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | macroautophagy |
| GO:0010506 | 0.0363225384236 | 0.5 | ATG101 ATG13 ULK1 RB1CC1 ULK2 | regulation of autophagy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATG101 | ATG13 | 0.998 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG101 | RB1CC1 | 0.998 | 0.212 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BRK1 | NCKAP1L | 0.997 | 0.322 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| HSBP1 | BRK1 | 0.996 | 0.038 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG101 | ULK1 | 0.996 | 0.104482142857 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RB1CC1 | FAM221B | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG101 | FAM221B | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RB1CC1 | BRK1 | 0.99 | 0.188 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG13 | FAM221B | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RB1CC1 | ATG13 | 0.982 | 0.222 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK1 | FAM221B | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG101 | ULK2 | 0.975 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PPFIA2 | BRK1 | 0.97 | 0.124 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| ATG101 | BRK1 | 0.969 | 0.054 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ULK1 | BRK1 | 0.922 | 0.168 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| ULK1 | ATG13 | 0.871 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK1 | RB1CC1 | 0.868 | 0.312 | bioplex_WMM bioplex3_WMM WMM_only |
| ATG13 | BRK1 | 0.856 | 0.1 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| ATG101 | HSBP1 | 0.74 | 0.06 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| RB1CC1 | NCKAP1L | 0.572 | 0.138 | bioplex3_WMM WMM_only |
| ATG101 | NCKAP1L | 0.48 | 0.036 | bioplex3_WMM WMM_only |
| ATG101 | PPFIA2 | 0.415 | 0.07 | bioplex3_WMM WMM_only |
| PPFIA2 | NCKAP1L | 0.415 | 0.066 | bioplex3_WMM WMM_only |
| ULK2 | ULK1 | 0.415 | bioplex3_WMM WMM_only | |
| ULK1 | PPFIA2 | 0.415 | 0.07 | bioplex3_WMM WMM_only |
| ATG13 | PPFIA2 | 0.415 | 0.086 | bioplex3_WMM WMM_only |
| ULK2 | ATG13 | 0.415 | bioplex3_WMM WMM_only | |
| RB1CC1 | HSBP1 | 0.385 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only |
| HSBP1 | NCKAP1L | 0.356 | 0.072 | bioplex3_WMM WMM_only |
| ULK1 | NCKAP1L | 0.278 | 0.124 | bioplex3_WMM WMM_only |
| ATG13 | NCKAP1L | 0.278 | 0.096 | bioplex3_WMM WMM_only |
| ATG13 | HSBP1 | 0.273 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK1 | HSBP1 | 0.273 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK2 | RB1CC1 | 0.25 | bioplex3_WMM WMM_only | |
| RB1CC1 | PPFIA2 | 0.25 | 0.114 | bioplex3_WMM WMM_only |
| HSBP1 | PPFIA2 | 0.078 | 0.026 | bioplex3_WMM WMM_only |
| ULK2 | HSBP1 | 0.027 | bioplex3_WMM WMM_only |
Related Complexes