hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13552.1
Complex Portal: CPX-17063
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLX1A | Structure-specific endonuclease subunit SLX1 (EC 3.1.-.-) (GIY-YIG domain-containing protein 1) | 5 | UniProt NCBI |
| FRY | Protein furry homolog | 5 | UniProt NCBI |
| PANK2 | Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)] | 5 | UniProt NCBI |
| MAP3K21 | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | 5 | UniProt NCBI |
| PANK3 | Pantothenate kinase 3 (hPanK3) (EC 2.7.1.33) (Pantothenic acid kinase 3) | 5 | UniProt NCBI |
| FRYL | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-196783 | 0.000319009353903 | 0.4 | PANK2 PANK3 | Coenzyme A biosynthesis |
| KEGG:00770 | 0.000616938529993 | 0.4 | PANK2 PANK3 | Pantothenate and CoA biosynthesis |
| REAC:R-HSA-199220 | 0.001593300657 | 0.4 | PANK2 PANK3 | Vitamin B5 (pantothenate) metabolism |
| GO:0004594 | 0.0140440992017 | 0.4 | PANK2 PANK3 | pantothenate kinase activity |
| KEGG:01240 | 0.0397793006284 | 0.4 | PANK2 PANK3 | Biosynthesis of cofactors |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FRY | FRYL | 0.99 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PANK2 | MAP3K21 | 0.977 | 0.054 | hein_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| FRYL | PANK2 | 0.962 | 0.016 | hein_WMM bioplex3_WMM WMM_only | |
| PANK2 | PANK3 | 0.917 | 0.124 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MAP3K21 | SLX1A | 0.909 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| FRYL | MAP3K21 | 0.898 | 0.084 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes