hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13555.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ALK | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | 5 | UniProt NCBI |
| RNF34 | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | 5 | UniProt NCBI |
| OR6Q1 | Olfactory receptor 6Q1 (Olfactory receptor OR11-226) | 3 | UniProt NCBI |
| RFFL | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | 5 | UniProt NCBI |
| GAREM2 | GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) | 3 | UniProt NCBI |
| SHC1 | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | 5 | UniProt NCBI |
| IQCE | IQ domain-containing protein E | 5 | UniProt NCBI |
| GAREM1 | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4928 | 0.00161645869838 | 0.285714285714 | ALK GAREM2 | MAPK pathway in congenital thyroid cancer |
| REAC:R-HSA-6804757 | 0.0225049419259 | 0.285714285714 | RNF34 RFFL | Regulation of TP53 Degradation |
| REAC:R-HSA-6806003 | 0.0238233224402 | 0.285714285714 | RNF34 RFFL | Regulation of TP53 Expression and Degradation |
| GO:2001271 | 0.0294899169624 | 0.285714285714 | RNF34 RFFL | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF34 | RFFL | 0.999 | 0.158 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| RFFL | IQCE | 0.999 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | |
| GAREM2 | GAREM1 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RFFL | SHC1 | 0.998 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | |
| GAREM1 | OR6Q1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SHC1 | GAREM1 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GAREM2 | OR6Q1 | 0.902 | bioplex3_WMM WMM_only | |
| RNF34 | SHC1 | 0.894 | bioplex_WMM bioplex3_WMM WMM_only | |
| SHC1 | OR6Q1 | 0.892 | bioplex3_WMM WMM_only | |
| RNF34 | IQCE | 0.878 | bioplex_WMM bioplex3_WMM WMM_only | |
| SHC1 | IQCE | 0.855 | bioplex_WMM bioplex3_WMM WMM_only | |
| SHC1 | ALK | 0.827 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SHC1 | GAREM2 | 0.796 | bioplex3_WMM WMM_only |
Related Complexes