hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13567.1
Complex Portal: CPX-21802
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PUF60 | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | 5 | UniProt NCBI |
| PRPF38B | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | 3 | UniProt NCBI |
| JMJD6 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | 5 | UniProt NCBI |
| PHRF1 | PHD and RING finger domain-containing protein 1 | 4 | UniProt NCBI |
| CKAP2 | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | 5 | UniProt NCBI |
| DDX41 | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | 5 | UniProt NCBI |
| TPX2 | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | 5 | UniProt NCBI |
| RBM25 | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | 5 | UniProt NCBI |
| PRPF38A | Pre-mRNA-splicing factor 38A | 5 | UniProt NCBI |
| SFSWAP | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03040 | 5.18213021533e-05 | 0.4 | PRPF38A RBM25 PUF60 PRPF38B | Spliceosome |
| GO:0000377 | 0.000339451176133 | 0.6 | DDX41 JMJD6 SFSWAP RBM25 PRPF38A PUF60 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.000339451176133 | 0.6 | DDX41 JMJD6 SFSWAP RBM25 PRPF38A PUF60 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.000371213922121 | 0.6 | DDX41 JMJD6 SFSWAP RBM25 PRPF38A PUF60 | RNA splicing, via transesterification reactions |
| GO:0006397 | 0.0013480773406 | 0.6 | DDX41 JMJD6 SFSWAP RBM25 PRPF38A PUF60 | mRNA processing |
| REAC:R-HSA-72163 | 0.00165087858779 | 0.4 | PRPF38A RBM25 PUF60 DDX41 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.00189067986721 | 0.4 | PRPF38A RBM25 PUF60 DDX41 | mRNA Splicing |
| GO:0008380 | 0.00228442103798 | 0.6 | DDX41 JMJD6 SFSWAP RBM25 PRPF38A PUF60 | RNA splicing |
| REAC:R-HSA-72203 | 0.00560918291311 | 0.4 | PRPF38A RBM25 PUF60 DDX41 | Processing of Capped Intron-Containing Pre-mRNA |
| CORUM:351 | 0.00672652736316 | 0.3 | RBM25 PUF60 DDX41 | Spliceosome |
| GO:0048024 | 0.0103846818546 | 0.4 | SFSWAP RBM25 PUF60 JMJD6 | regulation of mRNA splicing, via spliceosome |
| GO:0050684 | 0.0255498654968 | 0.4 | SFSWAP RBM25 PUF60 JMJD6 | regulation of mRNA processing |
| GO:0016071 | 0.0266308920315 | 0.6 | DDX41 JMJD6 SFSWAP RBM25 PRPF38A PUF60 | mRNA metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| JMJD6 | RBM25 | 0.999 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| JMJD6 | SFSWAP | 0.998 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| JMJD6 | PHRF1 | 0.998 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| JMJD6 | PRPF38A | 0.996 | 0.088 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction boldt_WMM |
| PUF60 | JMJD6 | 0.993 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction | |
| JMJD6 | PRPF38B | 0.968 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PUF60 | RBM25 | 0.963 | 0.694 |
structurally_consistent (O95232)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| DDX41 | PRPF38B | 0.919 | 0.12 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| RBM25 | SFSWAP | 0.857 | 0.206 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TPX2 | CKAP2 | 0.852 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () gupta_WMM | ||
| TPX2 | DDX41 | 0.83 | 0.152462264151 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only | |
| RBM25 | DDX41 | 0.829 | 0.468 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM WMM_only | |
| PHRF1 | PRPF38A | 0.806 | 0.104 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| PHRF1 | RBM25 | 0.758 | 0.24 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| JMJD6 | DDX41 | 0.71 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| DDX41 | CKAP2 | 0.607 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| RBM25 | TPX2 | 0.604 | 0.23 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PHRF1 | DDX41 | 0.565 | 0.108 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PHRF1 | SFSWAP | 0.564 | 0.124 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CKAP2 | SFSWAP | 0.469 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| PRPF38A | PRPF38B | 0.445 | 0.342 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TPX2 | PRPF38B | 0.444 | 0.104844789357 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only | |
| PRPF38A | DDX41 | 0.411 | 0.478 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| DDX41 | SFSWAP | 0.358 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only | |
| PRPF38B | SFSWAP | 0.352 | 0.088 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RBM25 | PRPF38B | 0.323 | 0.238 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PHRF1 | PRPF38B | 0.3 | 0.158 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PRPF38A | SFSWAP | 0.22 | 0.194 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PUF60 | PHRF1 | 0.154 | 0.492 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RBM25 | CKAP2 | 0.14 | bioplex3_HEK293 bioplex3_WMM boldt youn_WMM gupta_WMM WMM_only boldt_WMM | ||
| RBM25 | PRPF38A | 0.135 | 0.466 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| PUF60 | PRPF38A | 0.117 | 0.564 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| TPX2 | PRPF38A | 0.1 | 0.196 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PUF60 | SFSWAP | 0.086 | 0.193333333333 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| TPX2 | SFSWAP | 0.065 | 0.21 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PRPF38A | CKAP2 | 0.058 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| PUF60 | PRPF38B | 0.04 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| PHRF1 | TPX2 | 0.023 | 0.29 | youn_WMM WMM_only | |
| PRPF38B | CKAP2 | 0.018 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| PUF60 | DDX41 | 0.013 | 0.532 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM | |
| PUF60 | TPX2 | 0.012 | 0.362 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PHRF1 | CKAP2 | 0.012 | youn_WMM WMM_only | ||
| JMJD6 | TPX2 | 0.006 | 0.226462264151 | youn_WMM WMM_only | |
| PUF60 | CKAP2 | 0.002 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes