hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13571.1
Complex Portal: CPX-25583
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LRCH1 | Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81) | 5 | UniProt NCBI |
| LRCH4 | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | 5 | UniProt NCBI |
| DOCK8 | Dedicator of cytokinesis protein 8 | 5 | UniProt NCBI |
| LRCH2 | Leucine-rich repeat and calponin homology domain-containing protein 2 | 3 | UniProt NCBI |
| DOCK6 | Dedicator of cytokinesis protein 6 | 5 | UniProt NCBI |
| LRCH3 | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | 5 | UniProt NCBI |
| ISM2 | Isthmin-2 (Thrombospondin and AMOP domain-containing isthmin-like protein 1) (Thrombospondin type-1 domain-containing protein 3) | 4 | UniProt NCBI |
| AUTS2 | Autism susceptibility gene 2 protein | 5 | UniProt NCBI |
| DOCK7 | Dedicator of cytokinesis protein 7 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013148 | 0.0119915115759 | 0.333333333333 | DOCK6 DOCK8 DOCK7 | CDC42 GTPase cycle |
| REAC:R-HSA-983231 | 0.0230866683473 | 0.333333333333 | DOCK6 DOCK8 DOCK7 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-9013149 | 0.0235262214575 | 0.333333333333 | DOCK6 DOCK8 DOCK7 | RAC1 GTPase cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DOCK6 | LRCH3 | 1.0 | 0.024 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| DOCK7 | LRCH3 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | ||
| LRCH1 | LRCH3 | 1.0 | 0.026 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| LRCH1 | DOCK6 | 0.999 | 0.118 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| DOCK8 | DOCK7 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | ||
| DOCK8 | LRCH3 | 0.997 | 0.186 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRCH1 | LRCH4 | 0.997 | 0.068 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LRCH1 | DOCK7 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only boldt_WMM | ||
| LRCH2 | LRCH3 | 0.996 | 0.024 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| DOCK8 | LRCH4 | 0.995 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRCH2 | DOCK8 | 0.995 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRCH4 | LRCH3 | 0.993 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRCH1 | DOCK8 | 0.993 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRCH1 | LRCH2 | 0.992 | 0.082 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only | |
| DOCK6 | DOCK7 | 0.978 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| ISM2 | LRCH4 | 0.975 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| LRCH2 | DOCK7 | 0.961 | bioplex_WMM bioplex3_WMM boldt youn_WMM WMM_only boldt_WMM | ||
| LRCH4 | DOCK7 | 0.881 | bioplex_WMM bioplex3_WMM WMM_only | ||
| LRCH4 | DOCK6 | 0.878 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only | |
| ISM2 | DOCK6 | 0.865 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| AUTS2 | LRCH3 | 0.846 | 0.068 | boldt WMM_only boldt_WMM | |
| AUTS2 | DOCK7 | 0.846 | boldt WMM_only boldt_WMM | ||
| LRCH2 | ISM2 | 0.846 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DOCK8 | DOCK6 | 0.717 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRCH2 | DOCK6 | 0.51 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| ISM2 | DOCK7 | 0.493 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| LRCH2 | LRCH4 | 0.328 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| ISM2 | AUTS2 | 0.014 | youn_WMM WMM_only | ||
| LRCH2 | AUTS2 | 0.011 | 0.06 | boldt WMM_only boldt_WMM |
Related Complexes