hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13572.1
Complex Portal: CPX-20649
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARL3 | ADP-ribosylation factor-like protein 3 | 5 | UniProt NCBI |
| PDE6D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) | 5 | UniProt NCBI |
| FBXO10 | F-box only protein 10 | 5 | UniProt NCBI |
| TBC1D10A | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | 5 | UniProt NCBI |
| RPGR | X-linked retinitis pigmentosa GTPase regulator | 5 | UniProt NCBI |
| UBL3 | Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1) | 4 | UniProt NCBI |
| RAB28 | Ras-related protein Rab-28 | 5 | UniProt NCBI |
| INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6741 | 9.82248594942e-09 | 0.375 | PDE6D INPP5E RPGR | INPP5E-PDE6D-RPGR complex |
| WP:WP4803 | 7.7166218945e-05 | 0.5 | ARL3 INPP5E RAB28 PDE6D | Ciliopathies |
| HP:0001696 | 9.09271553791e-05 | 0.5 | ARL3 RPGR INPP5E PDE6D | Situs inversus totalis |
| HP:0011534 | 9.90991866292e-05 | 0.5 | ARL3 RPGR INPP5E PDE6D | Abnormal spatial orientation of the cardiac segments |
| REAC:R-HSA-5624958 | 0.000167311042734 | 0.25 | PDE6D INPP5E | ARL13B-mediated ciliary trafficking of INPP5E |
| HP:0001651 | 0.000185773831258 | 0.5 | ARL3 RPGR INPP5E PDE6D | Dextrocardia |
| HP:0004307 | 0.000192611932556 | 0.5 | ARL3 RPGR INPP5E PDE6D | Abnormal anatomic location of the heart |
| REAC:R-HSA-5620920 | 0.000343881525142 | 0.375 | ARL3 INPP5E PDE6D | Cargo trafficking to the periciliary membrane |
| HPA:0410561 | 0.000448468210995 | 0.25 | ARL3 RPGR | retina; limiting membrane[>=Low] |
| HPA:0410562 | 0.000448468210995 | 0.25 | ARL3 RPGR | retina; limiting membrane[>=Medium] |
| HP:0002419 | 0.000550944707746 | 0.375 | ARL3 INPP5E PDE6D | Molar tooth sign on MRI |
| WP:WP4656 | 0.000551678502006 | 0.375 | ARL3 INPP5E PDE6D | Joubert syndrome |
| HPA:0410553 | 0.000627683621469 | 0.25 | ARL3 RPGR | retina; ganglion cells [High] |
| WP:WP5234 | 0.00067768571707 | 0.375 | ARL3 INPP5E PDE6D | Bardet Biedl syndrome |
| HPA:0411253 | 0.00107544001022 | 0.25 | ARL3 RPGR | retina; nerve fiber layer[High] |
| HP:0000662 | 0.00120829036096 | 0.5 | ARL3 INPP5E RAB28 RPGR | Nyctalopia |
| HPA:0410552 | 0.00134393199505 | 0.25 | ARL3 RPGR | retina; ganglion cells [>=Medium] |
| HP:0002876 | 0.00168976340135 | 0.375 | ARL3 INPP5E PDE6D | Episodic tachypnea |
| HPA:0411263 | 0.00232756941496 | 0.25 | ARL3 RPGR | retina; outer plexiform layer[High] |
| HP:0004422 | 0.00267807580994 | 0.375 | ARL3 INPP5E PDE6D | Biparietal narrowing |
| HPA:0410551 | 0.00271475420109 | 0.25 | ARL3 RPGR | retina; ganglion cells [>=Low] |
| HPA:0411252 | 0.00271475420109 | 0.25 | ARL3 RPGR | retina; nerve fiber layer[>=Medium] |
| HP:0000613 | 0.00314468443624 | 0.5 | ARL3 INPP5E RAB28 RPGR | Photophobia |
| HPA:0411232 | 0.00405388351216 | 0.25 | ARL3 RPGR | retina; inner nuclear layer[>=Medium] |
| HPA:0411262 | 0.00405388351216 | 0.25 | ARL3 RPGR | retina; outer plexiform layer[>=Medium] |
| HP:0002418 | 0.00478067755223 | 0.375 | ARL3 INPP5E PDE6D | Abnormal midbrain morphology |
| HPA:0411251 | 0.00509437152039 | 0.25 | ARL3 RPGR | retina; nerve fiber layer[>=Low] |
| HP:5200058 | 0.00541559940504 | 0.5 | ARL3 INPP5E RAB28 RPGR | Sensory hypersensitivity |
| HP:0007675 | 0.00543763778541 | 0.375 | ARL3 INPP5E RPGR | Progressive night blindness |
| HPA:0411231 | 0.00565886293273 | 0.25 | ARL3 RPGR | retina; inner nuclear layer[>=Low] |
| HPA:0411261 | 0.00625282014335 | 0.25 | ARL3 RPGR | retina; outer plexiform layer[>=Low] |
| HP:5200046 | 0.0064851467263 | 0.5 | ARL3 INPP5E RAB28 RPGR | Sensory behavioral abnormality |
| HP:0011933 | 0.00812142628406 | 0.25 | ARL3 INPP5E | Elongated superior cerebellar peduncle |
| HP:0002789 | 0.00835350536242 | 0.375 | ARL3 INPP5E PDE6D | Tachypnea |
| HP:0000556 | 0.00920804331644 | 0.5 | ARL3 INPP5E RAB28 RPGR | Retinal dystrophy |
| HP:0011932 | 0.0101490036868 | 0.25 | ARL3 INPP5E | Abnormal superior cerebellar peduncle morphology |
| HP:0000657 | 0.013774736252 | 0.375 | ARL3 INPP5E PDE6D | Oculomotor apraxia |
| HP:0011931 | 0.014877056319 | 0.25 | ARL3 INPP5E | Abnormal cerebellar peduncle morphology |
| HP:0002084 | 0.0164669703279 | 0.375 | ARL3 INPP5E PDE6D | Encephalocele |
| HP:0011815 | 0.0164669703279 | 0.375 | ARL3 INPP5E PDE6D | Cephalocele |
| HP:0002335 | 0.0175771621337 | 0.25 | PDE6D INPP5E | Agenesis of cerebellar vermis |
| HP:0012501 | 0.0175771621337 | 0.25 | ARL3 INPP5E | Abnormal brainstem white matter morphology |
| HP:0000238 | 0.0180816098631 | 0.5 | ARL3 RPGR INPP5E PDE6D | Hydrocephalus |
| HP:0000479 | 0.0220670206652 | 0.625 | ARL3 RPGR INPP5E RAB28 PDE6D | Abnormal retinal morphology |
| HP:0001829 | 0.0234438911048 | 0.375 | ARL3 INPP5E PDE6D | Foot polydactyly |
| REAC:R-HSA-5617833 | 0.0241789966573 | 0.375 | ARL3 INPP5E PDE6D | Cilium Assembly |
| HP:0009136 | 0.0259270889741 | 0.375 | ARL3 INPP5E PDE6D | Duplication involving bones of the feet |
| HP:0034237 | 0.0299676437717 | 0.375 | ARL3 INPP5E PDE6D | Open neural tube defect |
| HP:0004362 | 0.0344027510839 | 0.375 | ARL3 INPP5E PDE6D | Abnormal enteric ganglion morphology |
| HP:0002251 | 0.0344027510839 | 0.375 | ARL3 INPP5E PDE6D | Aganglionic megacolon |
| HP:0012331 | 0.035181524859 | 0.375 | ARL3 INPP5E PDE6D | Abnormal autonomic nervous system morphology |
| HP:0025028 | 0.035181524859 | 0.375 | ARL3 INPP5E PDE6D | Abnormal enteric nervous system morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PDE6D | RPGR | 0.999 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| UBL3 | PDE6D | 0.999 | 0.058 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PDE6D | INPP5E | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| PDE6D | FBXO10 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PDE6D | RAB28 | 0.998 | 0.174 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| PDE6D | TBC1D10A | 0.997 | 0.06 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ARL3 | PDE6D | 0.985 | 0.282 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| INPP5E | RAB28 | 0.946 | bioplex3_WMM WMM_only | ||
| INPP5E | RPGR | 0.943 | bioplex3_WMM boldt WMM_only boldt_WMM | ||
| TBC1D10A | INPP5E | 0.931 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| UBL3 | INPP5E | 0.923 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| TBC1D10A | RAB28 | 0.826 | 0.116 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| FBXO10 | TBC1D10A | 0.77 | bioplex3_WMM WMM_only | ||
| FBXO10 | RPGR | 0.77 | bioplex3_WMM WMM_only | ||
| FBXO10 | INPP5E | 0.757 | bioplex3_WMM WMM_only | ||
| TBC1D10A | RPGR | 0.757 | 0.132 | bioplex3_WMM WMM_only | |
| UBL3 | FBXO10 | 0.734 | bioplex3_WMM WMM_only | ||
| UBL3 | TBC1D10A | 0.72 | 0.076 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| FBXO10 | RAB28 | 0.72 | bioplex3_WMM WMM_only | ||
| ARL3 | INPP5E | 0.676 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| ARL3 | TBC1D10A | 0.656 | 0.05 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| ARL3 | FBXO10 | 0.602 | 0.118 | bioplex3_WMM WMM_only | |
| RAB28 | RPGR | 0.572 | 0.072 | bioplex3_WMM gupta () | |
| UBL3 | RAB28 | 0.527 | 0.114 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| UBL3 | RPGR | 0.419 | 0.08 | bioplex3_WMM WMM_only | |
| ARL3 | RPGR | 0.348 | 0.076 | bioplex3_WMM WMM_only | |
| UBL3 | ARL3 | 0.328 | 0.064 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| ARL3 | RAB28 | 0.313 | 0.192 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
Related Complexes