hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13577.1
Complex Portal: CPX-11709
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MUC7 | Mucin-7 (MUC-7) (Apo-MG2) (Salivary mucin-7) | 5 | UniProt NCBI |
| FRMD1 | FERM domain-containing protein 1 | 3 | UniProt NCBI |
| HBM | Hemoglobin subunit mu (Hemoglobin mu chain) (Mu-globin) | 4 | UniProt NCBI |
| HID1 | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | 5 | UniProt NCBI |
| CRYGN | Gamma-crystallin N (Gamma-N-crystallin) | 3 | UniProt NCBI |
| LEG1 | Protein LEG1 homolog | 4 | UniProt NCBI |
| RCAN2 | Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4) | 4 | UniProt NCBI |
| CST2 | Cystatin-SA (Cystatin-2) (Cystatin-S5) | 5 | UniProt NCBI |
| B3GNT5 | Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5) | 5 | UniProt NCBI |
| JCHAIN | Immunoglobulin J chain (Joining chain of multimeric IgA and IgM) | 5 | UniProt NCBI |
| CRH | Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone) | 5 | UniProt NCBI |
| CA6 | Carbonic anhydrase 6 (EC 4.2.1.1) (Carbonate dehydratase VI) (Carbonic anhydrase VI) (CA-VI) (Salivary carbonic anhydrase) (Secreted carbonic anhydrase) | 5 | UniProt NCBI |
| TIMD4 | T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4) | 5 | UniProt NCBI |
| CST5 | Cystatin-D (Cystatin-5) | 5 | UniProt NCBI |
| FNBP4 | Formin-binding protein 4 (Formin-binding protein 30) | 4 | UniProt NCBI |
| AKNAD1 | Protein AKNAD1 | 3 | UniProt NCBI |
| RNF141 | RING finger protein 141 (Zinc finger protein 230) | 5 | UniProt NCBI |
| CRNN | Cornulin (53 kDa putative calcium-binding protein) (53 kDa squamous epithelial-induced stress protein) (58 kDa heat shock protein) (Squamous epithelial heat shock protein 53) (Tumor-related protein) | 5 | UniProt NCBI |
| PLEKHG6 | Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) | 5 | UniProt NCBI |
| AMY1C | Alpha-amylase 1C (EC 3.2.1.1) | 5 | UniProt NCBI |
| SPRR3 | Small proline-rich protein 3 (22 kDa pancornulin) (Cornifin beta) (Esophagin) | 5 | UniProt NCBI |
| MUC5B | Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin) | 5 | UniProt NCBI |
| CST4 | Cystatin-S (Cystatin-4) (Cystatin-SA-III) (Salivary acidic protein 1) | 5 | UniProt NCBI |
| ZNF491 | Zinc finger protein 491 | 4 | UniProt NCBI |
| CST1 | Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1) | 5 | UniProt NCBI |
| PIGR | Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] | 5 | UniProt NCBI |
| ABCA8 | ABC-type organic anion transporter ABCA8 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 8) | 5 | UniProt NCBI |
| JAK2 | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) | 5 | UniProt NCBI |
| C10orf53 | UPF0728 protein C10orf53 | 2 | UniProt NCBI |
| NPB | Neuropeptide B (Preproprotein L7) (hPPL7) [Cleaved into: Neuropeptide B-23 (NPB23) (hL7); Neuropeptide B-29 (NPB29) (hL7C)] | 3 | UniProt NCBI |
| HBQ1 | Hemoglobin subunit theta-1 (Hemoglobin theta-1 chain) (Theta-1-globin) | 4 | UniProt NCBI |
| LYZ | Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C) | 5 | UniProt NCBI |
| FAM89B | Leucine repeat adapter protein 25 | 3 | UniProt NCBI |
| ZG16B | Pancreatic adenocarcinoma up-regulated factor (Zymogen granule protein 16 homolog B) | 5 | UniProt NCBI |
| BPIFA2 | BPI fold-containing family A member 2 (Parotid secretory protein) (PSP) (Short palate, lung and nasal epithelium carcinoma-associated protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04970 | 6.94863073619e-09 | 0.205882352941 | MUC7 LYZ MUC5B CST4 CST1 AMY1C CST2 | Salivary secretion |
| GO:0001580 | 2.1010244429e-05 | 0.147058823529 | CST1 CST4 CST2 PIGR CA6 | detection of chemical stimulus involved in sensory perception of bitter taste |
| GO:0050913 | 2.1010244429e-05 | 0.147058823529 | CST1 CST4 CST2 PIGR CA6 | sensory perception of bitter taste |
| GO:0050912 | 2.84667309366e-05 | 0.147058823529 | CST1 CST4 CST2 PIGR CA6 | detection of chemical stimulus involved in sensory perception of taste |
| GO:0050909 | 0.00012878277565 | 0.147058823529 | CST1 CST4 CST2 PIGR CA6 | sensory perception of taste |
| GO:0050907 | 0.000773958466169 | 0.147058823529 | CST1 CST4 CST2 PIGR CA6 | detection of chemical stimulus involved in sensory perception |
| GO:0050906 | 0.00730620797622 | 0.147058823529 | CST1 CST4 CST2 PIGR CA6 | detection of stimulus involved in sensory perception |
| GO:0009593 | 0.00879556743911 | 0.147058823529 | CST1 CST4 CST2 PIGR CA6 | detection of chemical stimulus |
| GO:0007606 | 0.0135856128069 | 0.147058823529 | CST1 CST4 CST2 PIGR CA6 | sensory perception of chemical stimulus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| CST1 | CST4 | 1.0 |
mutually_exclusive (P06850)
|
|
| HBQ1 | HID1 | 1.0 | ||
| CRYGN | CA6 | 0.996 | ||
| CA6 | C10orf53 | 0.993 | ||
| PIGR | ZG16B | 0.993 |
structurally_consistent (Q6B0K9)
|
|
| FRMD1 | CA6 | 0.993 |
structurally_consistent (dimer)
|
|
| CA6 | AKNAD1 | 0.992 | ||
| MUC7 | C10orf53 | 0.992 | ||
| CST5 | AKNAD1 | 0.992 | ||
| BPIFA2 | AKNAD1 | 0.992 | ||
| PIGR | JCHAIN | 0.992 | 0.17 |
structurally_consistent (dimer)
|
| TIMD4 | SPRR3 | 0.992 | ||
| MUC7 | AMY1C | 0.99 | ||
| LEG1 | FRMD1 | 0.99 | ||
| CRH | CST5 | 0.99 | ||
| LEG1 | ZNF491 | 0.99 | ||
| CRH | BPIFA2 | 0.99 | ||
| PIGR | LYZ | 0.988 | 0.162 | |
| CST1 | MUC7 | 0.987 | ||
| MUC7 | CRNN | 0.987 | ||
| CA6 | ZNF491 | 0.987 | ||
| PIGR | CST1 | 0.986 | ||
| HBQ1 | CA6 | 0.985 |
structurally_consistent (dimer)
|
|
| PIGR | MUC7 | 0.985 | ||
| MUC7 | FRMD1 | 0.985 | ||
| FRMD1 | BPIFA2 | 0.985 | ||
| SPRR3 | FRMD1 | 0.983 | ||
| ZG16B | FRMD1 | 0.982 |
structurally_consistent (dimer)
|
|
| C10orf53 | AMY1C | 0.982 | ||
| PIGR | C10orf53 | 0.982 | ||
| MUC7 | LYZ | 0.982 | ||
| HBQ1 | LEG1 | 0.98 | ||
| PIGR | MUC5B | 0.98 | 0.1166 | |
| B3GNT5 | CRNN | 0.98 | ||
| MUC5B | FRMD1 | 0.98 | ||
| MUC7 | JCHAIN | 0.979 | ||
| CST1 | BPIFA2 | 0.979 | ||
| MUC7 | CST4 | 0.978 | ||
| ZG16B | AMY1C | 0.978 | ||
| MUC7 | ZNF491 | 0.978 | ||
| MUC7 | LEG1 | 0.978 | ||
| PIGR | AMY1C | 0.977 | 0.088 | |
| CST2 | C10orf53 | 0.977 | ||
| SPRR3 | FAM89B | 0.977 | ||
| JCHAIN | CST2 | 0.976 | ||
| LYZ | FRMD1 | 0.976 |
structurally_consistent (dimer)
|
|
| PIGR | LEG1 | 0.976 | ||
| AMY1C | AKNAD1 | 0.976 | ||
| MUC7 | CST2 | 0.975 | ||
| CST2 | BPIFA2 | 0.975 | ||
| CST2 | AKNAD1 | 0.974 | ||
| ABCA8 | CST2 | 0.974 | ||
| BPIFA2 | AMY1C | 0.974 | ||
| CRNN | CST2 | 0.972 | ||
| ZG16B | ZNF491 | 0.972 | ||
| ZG16B | NPB | 0.971 |
structurally_consistent (dimer)
|
|
| ZG16B | MUC7 | 0.971 | ||
| PLEKHG6 | CST1 | 0.97 | ||
| ZG16B | JCHAIN | 0.97 |
structurally_consistent (Q6B0K9)
|
|
| CRNN | CST4 | 0.97 | ||
| CST2 | ZNF491 | 0.97 | ||
| ZG16B | LYZ | 0.968 | ||
| CRYGN | CST2 | 0.967 | ||
| PIGR | CST4 | 0.966 | ||
| CST2 | AMY1C | 0.966 | ||
| CST1 | CRNN | 0.965 | ||
| HBQ1 | MUC7 | 0.964 | ||
| CST1 | CRYGN | 0.963 | ||
| CST1 | AKNAD1 | 0.963 | ||
| CST1 | RNF141 | 0.963 | ||
| CST1 | C10orf53 | 0.963 | ||
| JCHAIN | LEG1 | 0.962 | ||
| LYZ | LEG1 | 0.962 | ||
| ZG16B | LEG1 | 0.962 | ||
| FNBP4 | AMY1C | 0.961 | ||
| CST4 | AKNAD1 | 0.96 | ||
| ZNF491 | BPIFA2 | 0.96 | ||
| PLEKHG6 | BPIFA2 | 0.96 | ||
| CRNN | FRMD1 | 0.959 | ||
| JCHAIN | HBM | 0.959 |
structurally_consistent (dimer)
|
|
| JCHAIN | FRMD1 | 0.959 | ||
| C10orf53 | CST4 | 0.959 | ||
| MUC5B | LYZ | 0.959 | 0.024 | |
| JCHAIN | ZNF491 | 0.958 | ||
| RNF141 | CST4 | 0.958 | ||
| LEG1 | CST2 | 0.958 | ||
| CST1 | LEG1 | 0.957 | ||
| CRYGN | CST4 | 0.957 | ||
| CST5 | AMY1C | 0.955 | ||
| CRH | CST1 | 0.954 |
structurally_consistent (dimer)
|
|
| CRNN | SPRR3 | 0.954 | ||
| CST4 | BPIFA2 | 0.952 | ||
| CST1 | JCHAIN | 0.95 | ||
| ABCA8 | CST4 | 0.95 | ||
| CRH | CST4 | 0.95 |
structurally_consistent (dimer)
|
|
| FNBP4 | SPRR3 | 0.95 | ||
| MUC7 | SPRR3 | 0.949 | ||
| LYZ | CRNN | 0.949 | ||
| CST2 | CST5 | 0.948 | ||
| CRNN | AMY1C | 0.947 | ||
| MUC5B | HBM | 0.946 | ||
| CST1 | CST5 | 0.944 |
structurally_consistent (P09105)
|
|
| CST2 | CST4 | 0.944 |
mutually_exclusive (P09105)
|
|
| FRMD1 | CST2 | 0.942 | ||
| MUC5B | ZG16B | 0.942 | ||
| PIGR | HBM | 0.941 |
structurally_consistent (dimer)
|
|
| CST5 | BPIFA2 | 0.94 | ||
| PIGR | CST2 | 0.94 | ||
| LYZ | HBM | 0.939 | ||
| MUC7 | JAK2 | 0.937 | ||
| MUC5B | MUC7 | 0.937 | ||
| LEG1 | CST4 | 0.937 | ||
| MUC5B | CST1 | 0.933 | ||
| MUC7 | BPIFA2 | 0.932 | ||
| JCHAIN | BPIFA2 | 0.932 | ||
| NPB | AMY1C | 0.932 | ||
| SPRR3 | AMY1C | 0.931 | ||
| CST1 | HBM | 0.928 | ||
| ZG16B | C10orf53 | 0.927 | ||
| CST5 | ZNF491 | 0.924 | ||
| CRNN | FNBP4 | 0.921 | ||
| CST5 | CST4 | 0.919 |
structurally_consistent (P09105)
|
|
| MUC5B | BPIFA2 | 0.919 | ||
| CST1 | CST2 | 0.918 | ||
| ZG16B | SPRR3 | 0.918 | ||
| ZG16B | CST4 | 0.918 |
mutually_exclusive (Q8N878)
|
|
| LYZ | B3GNT5 | 0.917 | ||
| HBQ1 | CST2 | 0.915 |
structurally_consistent (dimer)
|
|
| CST1 | AMY1C | 0.915 | ||
| MUC7 | RCAN2 | 0.914 | ||
| ZG16B | CRYGN | 0.912 | ||
| MUC5B | JCHAIN | 0.911 | 0.104 | |
| SPRR3 | CST2 | 0.91 | ||
| CST1 | LYZ | 0.909 | ||
| PIGR | NPB | 0.908 | ||
| MUC5B | CRNN | 0.907 | ||
| CST1 | HBQ1 | 0.907 |
structurally_consistent (dimer)
|
|
| CST2 | NPB | 0.901 | ||
| TIMD4 | LYZ | 0.898 | ||
| CST4 | AMY1C | 0.897 | ||
| MUC7 | NPB | 0.894 | ||
| LYZ | CST2 | 0.893 | ||
| CA6 | AMY1C | 0.892 | ||
| CST1 | FRMD1 | 0.89 | ||
| JCHAIN | NPB | 0.89 | ||
| MUC7 | CA6 | 0.888 | ||
| CA6 | BPIFA2 | 0.886 | ||
| PIGR | CRNN | 0.886 | ||
| ZG16B | CST5 | 0.882 | ||
| ZG16B | BPIFA2 | 0.877 | ||
| FRMD1 | CST5 | 0.877 | ||
| PLEKHG6 | CST5 | 0.877 | ||
| ZG16B | CST2 | 0.872 | ||
| MUC5B | LEG1 | 0.865 | ||
| PIGR | FRMD1 | 0.864 | ||
| LEG1 | AMY1C | 0.858 | ||
| ZG16B | CST1 | 0.856 | ||
| MUC5B | CST4 | 0.855 | ||
| LYZ | CST4 | 0.852 | ||
| SPRR3 | RCAN2 | 0.844 | ||
| CST2 | CA6 | 0.839 | ||
| PLEKHG6 | JCHAIN | 0.837 | ||
| CST5 | CA6 | 0.833 |
structurally_consistent (P09105)
|
|
| HBQ1 | CST4 | 0.832 |
structurally_consistent (dimer)
|
|
| HBQ1 | BPIFA2 | 0.83 | ||
| JCHAIN | AMY1C | 0.83 | 0.142 | |
| SPRR3 | JAK2 | 0.828 | ||
| CST1 | SPRR3 | 0.828 | ||
| LYZ | FAM89B | 0.825 | 0.102 | |
| TIMD4 | CRNN | 0.824 | ||
| RCAN2 | AMY1C | 0.823 | ||
| ZG16B | RCAN2 | 0.821 | ||
| JCHAIN | JAK2 | 0.813 | 0.262 | |
| HBQ1 | JCHAIN | 0.81 | ||
| ZG16B | CRNN | 0.808 | ||
| LEG1 | CA6 | 0.808 | ||
| LYZ | FNBP4 | 0.803 | 0.066 | |
| LYZ | BPIFA2 | 0.802 | ||
| CST1 | CA6 | 0.802 | ||
| HBQ1 | CST5 | 0.801 |
structurally_consistent (dimer)
|
|
| CRNN | CA6 | 0.8 | ||
| BPIFA2 | JAK2 | 0.798 | ||
| FRMD1 | AMY1C | 0.797 | ||
| ZG16B | CRH | 0.797 | ||
| SPRR3 | CA6 | 0.793 | ||
| LEG1 | SPRR3 | 0.792 | ||
| JCHAIN | LYZ | 0.792 | 0.246 | |
| LYZ | AMY1C | 0.791 | 0.19 | |
| MUC5B | SPRR3 | 0.784 | ||
| LEG1 | CST5 | 0.782 | ||
| LEG1 | BPIFA2 | 0.782 | ||
| ZG16B | HBQ1 | 0.78 | ||
| JCHAIN | CST4 | 0.779 | ||
| CA6 | CST4 | 0.778 | ||
| JCHAIN | SPRR3 | 0.753 | ||
| ZG16B | PLEKHG6 | 0.748 | ||
| JCHAIN | CST5 | 0.743 | ||
| CST2 | RCAN2 | 0.74 | ||
| PIGR | SPRR3 | 0.716 | ||
| FRMD1 | CST4 | 0.71 |
structurally_consistent (dimer)
|
|
| JCHAIN | CRNN | 0.706 | ||
| LEG1 | CRNN | 0.704 | ||
| SPRR3 | CST4 | 0.694 | ||
| ZG16B | CA6 | 0.69 |
mutually_exclusive (Q8N878)
|
|
| PLEKHG6 | AMY1C | 0.689 | ||
| CST1 | JAK2 | 0.685 | ||
| LYZ | SPRR3 | 0.681 | ||
| HBQ1 | AMY1C | 0.68 | ||
| PIGR | CA6 | 0.678 | ||
| MUC7 | CST5 | 0.672 | ||
| ZG16B | HBM | 0.637 |
structurally_consistent (dimer)
|
|
| NPB | CST4 | 0.624 | ||
| CST1 | RCAN2 | 0.621 | ||
| MUC5B | CST5 | 0.595 | ||
| CRNN | BPIFA2 | 0.542 | ||
| AMY1C | JAK2 | 0.508 | ||
| HBM | CST4 | 0.504 |
structurally_consistent (dimer)
|
|
| PLEKHG6 | CST4 | 0.494 | ||
| PIGR | BPIFA2 | 0.467 | ||
| SPRR3 | BPIFA2 | 0.463 | ||
| PIGR | ZNF491 | 0.444 | ||
| JCHAIN | CA6 | 0.431 | ||
| ZNF491 | CST4 | 0.425 | ||
| PIGR | CST5 | 0.42 | ||
| CRNN | RCAN2 | 0.409 | ||
| RCAN2 | CST4 | 0.399 | ||
| PIGR | HBQ1 | 0.395 | ||
| LYZ | CA6 | 0.367 | ||
| SPRR3 | CST5 | 0.347 | ||
| MUC5B | CST2 | 0.335 | ||
| PIGR | PLEKHG6 | 0.327 | ||
| ZG16B | FAM89B | 0.324 | ||
| CST2 | JAK2 | 0.312 | ||
| MUC5B | CA6 | 0.307 | ||
| ZG16B | JAK2 | 0.302 | ||
| CRNN | CST5 | 0.29 | ||
| LYZ | NPB | 0.259 | ||
| MUC5B | JAK2 | 0.248 | ||
| CRNN | NPB | 0.234 | ||
| ZNF491 | AMY1C | 0.221 | ||
| MUC5B | AMY1C | 0.2 | 0.082 | |
| LYZ | ZNF491 | 0.198 | ||
| ZG16B | FNBP4 | 0.178 | ||
| LYZ | CST5 | 0.159 | ||
| HBQ1 | LYZ | 0.146 | ||
| HID1 | CST2 | 0.113 | ||
| ZG16B | HID1 | 0.096 | ||
| PIGR | JAK2 | 0.087 | ||
| HID1 | CA6 | 0.078 | ||
| HID1 | BPIFA2 | 0.076 | ||
| HID1 | CST5 | 0.076 | ||
| HID1 | MUC7 | 0.076 | ||
| HID1 | LEG1 | 0.076 | ||
| HID1 | AMY1C | 0.076 | ||
| CST1 | HID1 | 0.064 | ||
| HID1 | JCHAIN | 0.063 | 0.07 | |
| FNBP4 | CST4 | 0.057 | ||
| HID1 | CST4 | 0.055 | ||
| HID1 | LYZ | 0.054 | 0.036 | |
| CST1 | FAM89B | 0.041 | ||
| ABCA8 | AMY1C | 0.034 | ||
| PIGR | CRYGN | 0.03 | ||
| TIMD4 | AMY1C | 0.03 | ||
| RNF141 | LYZ | 0.025 | 0.046 | |
| ZG16B | AKNAD1 | 0.022 | ||
| PIGR | HID1 | 0.022 | ||
| TIMD4 | ZG16B | 0.02 | ||
| ZG16B | RNF141 | 0.018 | ||
| ZG16B | ABCA8 | 0.017 | ||
| B3GNT5 | AMY1C | 0.014 | ||
| FAM89B | CST4 | 0.013 | ||
| CRNN | ZNF491 | 0.012 |
Related Complexes