hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13591.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GSTA2 | Glutathione S-transferase A2 (EC 2.5.1.18) (GST HA subunit 2) (GST class-alpha member 2) (GST-gamma) (GSTA2-2) (GTH2) | 5 | UniProt NCBI |
| GSTA4 | Glutathione S-transferase A4 (EC 2.5.1.18) (GST class-alpha member 4) (Glutathione S-transferase A4-4) | 5 | UniProt NCBI |
| GSTA1 | Glutathione S-transferase A1 (EC 2.5.1.18) (13-hydroperoxyoctadecadienoate peroxidase) (EC 1.11.1.-) (Androst-5-ene-3,17-dione isomerase) (EC 5.3.3.-) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed] | 5 | UniProt NCBI |
| GSTA5 | Glutathione S-transferase A5 (EC 2.5.1.18) (GST class-alpha member 5) (Glutathione S-transferase A5-5) | 4 | UniProt NCBI |
| GSTA3 | Glutathione S-transferase A3 (EC 2.5.1.18) (GST class-alpha member 3) (Glutathione S-transferase A3-3) | 5 | UniProt NCBI |
| STARD6 | StAR-related lipid transfer protein 6 (START domain-containing protein 6) (StARD6) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-156590 | 3.99369641675e-11 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Glutathione conjugation |
| KEGG:00480 | 1.18193631466e-10 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Glutathione metabolism |
| KEGG:05204 | 1.60056024847e-10 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 1.76378183727e-10 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Drug metabolism - cytochrome P450 |
| KEGG:00980 | 2.79134211037e-10 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 5.38221792566e-10 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Drug metabolism - other enzymes |
| KEGG:01524 | 6.74386483027e-10 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Platinum drug resistance |
| GO:0004364 | 1.42135021777e-09 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | glutathione transferase activity |
| REAC:R-HSA-156580 | 4.75455184853e-09 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Phase II - Conjugation of compounds |
| KEGG:05418 | 9.31084060402e-09 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Fluid shear stress and atherosclerosis |
| WP:WP2884 | 1.03351510944e-08 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | NRF2 pathway |
| GO:0006749 | 1.5008288106e-08 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | glutathione metabolic process |
| WP:WP702 | 2.66744026378e-08 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Metapathway biotransformation Phase I and II |
| KEGG:05225 | 4.40580942992e-08 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Hepatocellular carcinoma |
| KEGG:05207 | 4.99529538345e-08 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Chemical carcinogenesis - receptor activation |
| KEGG:05208 | 1.47446779161e-07 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Chemical carcinogenesis - reactive oxygen species |
| GO:0016765 | 1.54614120002e-07 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| REAC:R-HSA-211859 | 1.77406446339e-07 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Biological oxidations |
| WP:WP2882 | 6.09559807665e-07 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Nuclear receptors meta pathway |
| GO:0006805 | 1.98692887304e-06 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | xenobiotic metabolic process |
| GO:0071466 | 6.27436281495e-06 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | cellular response to xenobiotic stimulus |
| KEGG:05200 | 7.83947653613e-06 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Pathways in cancer |
| GO:0006575 | 8.99427202349e-06 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | cellular modified amino acid metabolic process |
| GO:0009410 | 2.31741536755e-05 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | response to xenobiotic stimulus |
| HPA:0400201 | 7.2334472862e-05 | 0.666666666667 | GSTA4 GSTA3 GSTA2 GSTA1 | rectum; endothelial cells[>=Low] |
| HPA:0151293 | 0.000138923860796 | 0.666666666667 | GSTA4 GSTA3 GSTA2 GSTA1 | duodenum; endocrine cells[High] |
| GO:0006790 | 0.000353616039768 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | sulfur compound metabolic process |
| HPA:0151302 | 0.000551180321463 | 0.666666666667 | GSTA4 GSTA3 GSTA2 GSTA1 | duodenum; enterocytes[>=Medium] |
| REAC:R-HSA-1430728 | 0.000579637081746 | 1.0 | GSTA4 GSTA3 STARD6 GSTA2 GSTA5 GSTA1 | Metabolism |
| HPA:0151292 | 0.000660173259584 | 0.666666666667 | GSTA4 GSTA3 GSTA2 GSTA1 | duodenum; endocrine cells[>=Medium] |
| HPA:0151291 | 0.000899230802304 | 0.666666666667 | GSTA4 GSTA3 GSTA2 GSTA1 | duodenum; endocrine cells[>=Low] |
| HPA:0151301 | 0.00125162636918 | 0.666666666667 | GSTA4 GSTA3 GSTA2 GSTA1 | duodenum; enterocytes[>=Low] |
| HPA:0401331 | 0.00126268500746 | 0.666666666667 | GSTA4 GSTA3 GSTA2 GSTA1 | rectum; mucosal lymphoid cells[>=Low] |
| WP:WP100 | 0.00136659658622 | 0.333333333333 | GSTA5 GSTA1 | Glutathione metabolism |
| HPA:0481301 | 0.00144969220191 | 0.666666666667 | GSTA4 GSTA3 GSTA2 GSTA1 | small intestine; enterocytes[>=Low] |
| KEGG:01100 | 0.00157235036995 | 0.833333333333 | GSTA3 GSTA4 GSTA5 GSTA2 GSTA1 | Metabolic pathways |
| WP:WP5066 | 0.00171766688832 | 0.333333333333 | GSTA2 GSTA1 | FOXA2 pathway |
| REAC:R-HSA-9818027 | 0.00309047926945 | 0.333333333333 | GSTA1 GSTA3 | NFE2L2 regulating anti-oxidant/detoxification enzymes |
| REAC:R-HSA-9748787 | 0.00440152140132 | 0.333333333333 | GSTA2 GSTA1 | Azathioprine ADME |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GSTA1 | GSTA3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSTA1 | GSTA4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSTA2 | GSTA4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSTA2 | GSTA5 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GSTA2 | GSTA3 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GSTA2 | GSTA1 | 0.98 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| STARD6 | GSTA4 | 0.967 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GSTA1 | GSTA5 | 0.951 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GSTA3 | GSTA4 | 0.942 | bioplex_WMM bioplex3_WMM WMM_only | |
| GSTA5 | GSTA4 | 0.891 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| GSTA5 | GSTA3 | 0.582 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| GSTA2 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_13591.1 |
| GSTA4 | huMAP3_05333.1 huMAP3_10880.1 huMAP3_13591.1 |
| GSTA1 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_13591.1 |
| GSTA5 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_11246.1 huMAP3_13591.1 |
| GSTA3 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_13591.1 |
| STARD6 | huMAP3_05333.1 huMAP3_10880.1 huMAP3_13591.1 |