hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13592.1
Complex Portal: CPX-11411
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CHP2 | Calcineurin B homologous protein 2 (Hepatocellular carcinoma-associated antigen 520) | 5 | UniProt NCBI |
| IMPA2 | Inositol monophosphatase 2 (IMP 2) (IMPase 2) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2) | 5 | UniProt NCBI |
| ASAH1 | Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylethanolamine hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) (Putative 32 kDa heart protein) (PHP32) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta] | 5 | UniProt NCBI |
| OBSCN | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | 5 | UniProt NCBI |
| CTSH | Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] | 5 | UniProt NCBI |
| KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir1.3) (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15) | 5 | UniProt NCBI |
| PM20D1 | N-fatty-acyl-amino acid synthase/hydrolase PM20D1 (EC 3.5.1.114) (EC 3.5.1.14) (Peptidase M20 domain-containing protein 1) | 5 | UniProt NCBI |
| NT5C1A | Cytosolic 5'-nucleotidase 1A (cN1A) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.99) (5'-deoxynucleotidase) (Cytosolic 5'-nucleotidase IA) (cN-I) (cN-IA) | 5 | UniProt NCBI |
| NPPA | Natriuretic peptides A (Atrial natriuretic factor prohormone) (proANF) (Atrial natriuretic peptide prohormone) (preproANP) (proANP) (Atriopeptigen) (Cardiodilatin) (CDD) (preproCDD-ANF) [Cleaved into: Long-acting natriuretic peptide (LANP) (Long-acting natriuretic hormone) (LANH) (Pro atrial natriuretic factor 1-30) (proANF 1-30) (Pro atrial natriuretic peptide 1-30) (proANP 1-30); Vessel dilator (VSDL) (Pro atrial natriuretic factor 31-67) (proANF 31-67) (Pro atrial natriuretic peptide 31-67) (proANP 31-67); Kaliuretic peptide (KP) (Pro atrial natriuretic factor 79-98) (proANF 79-98) (Pro atrial natriuretic peptide 79-98) (proANP 79-98); Urodilatin (URO) (CDD 95-126) (CDD-ANP (95-126)) (Pro atrial natriuretic peptide 95-126) (proANP 95-126); Auriculin-C (Atrial natriuretic factor 1-33) (ANF 1-33); Auriculin-D (Atrial natriuretic factor 3-33) (ANF 3-33); Atrial natriuretic peptide (ANP) (Alpha-atrial natriuretic peptide) (Alpha-hANP) (Atrial natriuretic factor) (ANF) (CDD-ANF) (CDD-ANP (99-126)) (Cardionatrin) (Pro atrial natriuretic factor 99-126) (proANF 99-126); Auriculin-B (Atrial natriuretic factor 8-33) (ANF 8-33); Auriculin-A; Atriopeptin-1 (Atriopeptin I); Atriopeptin-2 (Atriopeptin II); Atriopeptin-3 (Atriopeptin III)] | 5 | UniProt NCBI |
| SDR9C7 | Short-chain dehydrogenase/reductase family 9C member 7 (EC 1.1.1.-) (Orphan short-chain dehydrogenase/reductase) (SDR-O) (RDH-S) | 4 | UniProt NCBI |
| GDPD3 | Lysophospholipase D GDPD3 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 7) (Glycerophosphodiester phosphodiesterase domain-containing protein 3) | 5 | UniProt NCBI |
| ZIC1 | Zinc finger protein ZIC 1 (Zinc finger protein 201) (Zinc finger protein of the cerebellum 1) | 5 | UniProt NCBI |
| NFAM1 | NFAT activation molecule 1 (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1) | 5 | UniProt NCBI |
| AIRE | Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1985 | 0.0499958217778 | 0.0714285714286 | AIRE | AIRE homodimer complex |
| CORUM:7098 | 0.0499958217778 | 0.0714285714286 | ASAH1 | ASAH1-NR5A1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| OBSCN | NPPA | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KCNJ15 | PM20D1 | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NPPA | PM20D1 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTSH | ZIC1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SDR9C7 | ZIC1 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NFAM1 | GDPD3 | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SDR9C7 | IMPA2 | 0.976 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AIRE | CTSH | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTSH | GDPD3 | 0.973 | 0.176 | bioplex_WMM bioplex3_WMM WMM_only | |
| NFAM1 | SDR9C7 | 0.97 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NT5C1A | PM20D1 | 0.97 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NT5C1A | GDPD3 | 0.967 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NT5C1A | IMPA2 | 0.962 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NPPA | SDR9C7 | 0.947 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZIC1 | IMPA2 | 0.941 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GDPD3 | ZIC1 | 0.939 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NPPA | GDPD3 | 0.938 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ASAH1 | NT5C1A | 0.93 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ASAH1 | CHP2 | 0.927 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CTSH | NT5C1A | 0.927 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NPPA | IMPA2 | 0.922 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ASAH1 | SDR9C7 | 0.92 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AIRE | GDPD3 | 0.893 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GDPD3 | SDR9C7 | 0.879 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PM20D1 | GDPD3 | 0.847 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CTSH | SDR9C7 | 0.842 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ASAH1 | CTSH | 0.815 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only | |
| PM20D1 | IMPA2 | 0.809 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NT5C1A | SDR9C7 | 0.8 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GDPD3 | IMPA2 | 0.779 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| PM20D1 | SDR9C7 | 0.775 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ASAH1 | IMPA2 | 0.774 | 0.04 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTSH | IMPA2 | 0.685 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only | |
| ASAH1 | GDPD3 | 0.56 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTSH | PM20D1 | 0.543 | bioplex3_WMM WMM_only | ||
| ASAH1 | PM20D1 | 0.476 | bioplex3_WMM WMM_only | ||
| AIRE | SDR9C7 | 0.474 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ASAH1 | ZIC1 | 0.258 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ASAH1 | AIRE | 0.229 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| OBSCN | SDR9C7 | 0.179 | bioplex_WMM bioplex3_WMM WMM_only | ||
| OBSCN | PM20D1 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| OBSCN | IMPA2 | 0.143 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| OBSCN | GDPD3 | 0.143 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes