hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13605.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TCAIM | T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1) | 3 | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | 5 | UniProt NCBI |
| ARMS2 | Age-related maculopathy susceptibility protein 2 | 3 | UniProt NCBI |
| KGD4 | Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4) | 3 | UniProt NCBI |
| SIAH1 | E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a) | 5 | UniProt NCBI |
| PAGE2B | Putative G antigen family E member 3 (Prostate-associated gene 2B protein) (PAGE-2B) | 2 | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | 5 | UniProt NCBI |
| SIAH2 | E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) | 5 | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045252 | 1.1594342202e-07 | 0.444444444444 | OGDHL KGD4 OGDH DLST | oxoglutarate dehydrogenase complex |
| GO:0045240 | 1.09198397762e-06 | 0.444444444444 | OGDHL KGD4 OGDH DLST | dihydrolipoyl dehydrogenase complex |
| GO:0006103 | 2.3646695756e-06 | 0.444444444444 | OGDHL KGD4 OGDH DLST | 2-oxoglutarate metabolic process |
| KEGG:00785 | 6.63101624771e-06 | 0.333333333333 | OGDHL DLST OGDH | Lipoic acid metabolism |
| GO:0045239 | 7.86258774297e-06 | 0.444444444444 | OGDHL KGD4 OGDH DLST | tricarboxylic acid cycle enzyme complex |
| GO:0004591 | 8.07408345042e-06 | 0.333333333333 | OGDHL KGD4 OGDH | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| KEGG:00020 | 3.28707503917e-05 | 0.333333333333 | OGDHL DLST OGDH | Citrate cycle (TCA cycle) |
| KEGG:01210 | 3.28707503917e-05 | 0.333333333333 | OGDHL DLST OGDH | 2-Oxocarboxylic acid metabolism |
| GO:0006099 | 3.50368755955e-05 | 0.444444444444 | OGDHL KGD4 OGDH DLST | tricarboxylic acid cycle |
| CORUM:7267 | 0.000164069436391 | 0.222222222222 | DLST OGDH | KAT2A-Oxoglutarate dehydrogenase complex |
| GO:0016624 | 0.00045145282213 | 0.333333333333 | OGDHL KGD4 OGDH | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| KEGG:01200 | 0.00144106213769 | 0.333333333333 | OGDHL DLST OGDH | Carbon metabolism |
| GO:0043648 | 0.0020721506318 | 0.444444444444 | OGDHL KGD4 OGDH DLST | dicarboxylic acid metabolic process |
| WP:WP2453 | 0.00367445660497 | 0.222222222222 | DLST OGDH | TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc |
| REAC:R-HSA-71064 | 0.00438093013445 | 0.222222222222 | DLST OGDH | Lysine catabolism |
| WP:WP78 | 0.00468193988771 | 0.222222222222 | DLST OGDH | TCA cycle aka Krebs or citric acid cycle |
| REAC:R-HSA-71403 | 0.0166738379974 | 0.222222222222 | DLST OGDH | Citric acid cycle (TCA cycle) |
| HPA:0570811 | 0.0179444989277 | 0.777777777778 | PAGE2B SIAH1 OGDH SIAH2 DLST OGDHL KGD4 | testis; spermatogonia cells[>=Low] |
| GO:1990204 | 0.0199898670751 | 0.444444444444 | OGDHL KGD4 OGDH DLST | oxidoreductase complex |
| REAC:R-HSA-389661 | 0.0237893486791 | 0.222222222222 | DLST OGDH | Glyoxylate metabolism and glycine degradation |
| WP:WP5352 | 0.0327744959876 | 0.222222222222 | OGDHL DLST | 10q11 21q11 23 copy number variation syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SIAH1 | SIAH2 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| OGDH | DLST | 1.0 | 0.658 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM |
| OGDH | KGD4 | 0.999 | 0.512 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| KGD4 | DLST | 0.999 | 0.336 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| OGDHL | DLST | 0.999 | 0.74 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| OGDHL | OGDH | 0.998 | 0.966 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| OGDHL | KGD4 | 0.997 | 0.53 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| OGDHL | PAGE2B | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SIAH1 | DLST | 0.979 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TCAIM | DLST | 0.965 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SIAH1 | OGDHL | 0.965 | 0.078 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SIAH1 | KGD4 | 0.957 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| OGDHL | TCAIM | 0.956 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SIAH1 | OGDH | 0.942 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TCAIM | KGD4 | 0.936 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| TCAIM | OGDH | 0.934 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SIAH2 | DLST | 0.9 | bioplex_WMM bioplex3_WMM WMM_only | |
| OGDHL | SIAH2 | 0.897 | bioplex_WMM bioplex3_WMM WMM_only | |
| SIAH2 | OGDH | 0.817 | bioplex_WMM bioplex3_WMM WMM_only | |
| OGDHL | ARMS2 | 0.811 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SIAH2 | KGD4 | 0.752 | bioplex_WMM bioplex3_WMM WMM_only | |
| PAGE2B | DLST | 0.704 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SIAH2 | TCAIM | 0.377 | bioplex_WMM bioplex3_WMM WMM_only | |
| SIAH1 | TCAIM | 0.224 | bioplex_WMM bioplex3_WMM WMM_only | |
| PAGE2B | KGD4 | 0.159 | bioplex3_WMM WMM_only | |
| OGDH | ARMS2 | 0.13 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PAGE2B | OGDH | 0.11 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KGD4 | ARMS2 | 0.074 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| DLST | ARMS2 | 0.072 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PAGE2B | TCAIM | 0.055 | bioplex3_WMM WMM_only |
Related Complexes