hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13609.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UFD1 | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | 5 | UniProt NCBI |
| DEGS1 | Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Membrane lipid desaturase) (Retinol isomerase) (EC 5.2.1.-) | 5 | UniProt NCBI |
| TMEM31 | Transmembrane protein 31 | 2 | UniProt NCBI |
| NPLOC4 | Nuclear protein localization protein 4 homolog (Protein NPL4) | 5 | UniProt NCBI |
| TMEM62 | Transmembrane protein 62 | 2 | UniProt NCBI |
| VCP | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | 5 | UniProt NCBI |
| FADS1 | Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-110320 | 1.25938591632e-05 | 0.428571428571 | UFD1 VCP NPLOC4 | Translesion Synthesis by POLH |
| CORUM:5685 | 6.1565588648e-05 | 0.285714285714 | UFD1 VCP | Membrane protein complex (VCP, UFD1L, SEC61B) |
| REAC:R-HSA-110313 | 0.000109213310364 | 0.428571428571 | UFD1 VCP NPLOC4 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| CORUM:6280 | 0.000123103089524 | 0.285714285714 | UFD1 NPLOC4 | NUB1L-UFD1-NPL4-NEDD8 complex |
| GO:0034098 | 0.0001882019462 | 0.428571428571 | UFD1 VCP NPLOC4 | VCP-NPL4-UFD1 AAA ATPase complex |
| REAC:R-HSA-73893 | 0.000209532838622 | 0.428571428571 | UFD1 VCP NPLOC4 | DNA Damage Bypass |
| KEGG:04141 | 0.00211181505065 | 0.428571428571 | UFD1 VCP NPLOC4 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-9755511 | 0.0023257157346 | 0.428571428571 | UFD1 VCP NPLOC4 | KEAP1-NFE2L2 pathway |
| GO:0030970 | 0.00979189312029 | 0.428571428571 | UFD1 VCP NPLOC4 | retrograde protein transport, ER to cytosol |
| GO:1903513 | 0.00979189312029 | 0.428571428571 | UFD1 VCP NPLOC4 | endoplasmic reticulum to cytosol transport |
| GO:0036501 | 0.00983221512175 | 0.285714285714 | UFD1 NPLOC4 | UFD1-NPL4 complex |
| REAC:R-HSA-9711123 | 0.0126241322329 | 0.428571428571 | UFD1 VCP NPLOC4 | Cellular response to chemical stress |
| REAC:R-HSA-8951664 | 0.0233324089042 | 0.428571428571 | UFD1 VCP NPLOC4 | Neddylation |
| GO:0032527 | 0.0441816577212 | 0.428571428571 | UFD1 VCP NPLOC4 | protein exit from endoplasmic reticulum |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UFD1 | NPLOC4 | 1.0 | 0.738 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| UFD1 | VCP | 0.992 | 0.582 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NPLOC4 | VCP | 0.976 | 0.712 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| TMEM31 | VCP | 0.974 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DEGS1 | NPLOC4 | 0.965 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TMEM31 | NPLOC4 | 0.963 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DEGS1 | UFD1 | 0.936 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TMEM62 | NPLOC4 | 0.923 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TMEM62 | VCP | 0.919 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| FADS1 | DEGS1 | 0.894 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only |
| TMEM62 | UFD1 | 0.891 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| FADS1 | NPLOC4 | 0.878 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TMEM31 | UFD1 | 0.851 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FADS1 | UFD1 | 0.849 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FADS1 | VCP | 0.288 | 0.314 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DEGS1 | VCP | 0.269 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
| DEGS1 | TMEM62 | 0.09 | 0.05 | bioplex3_WMM WMM_only |
| FADS1 | TMEM62 | 0.052 | 0.06 | bioplex3_WMM WMM_only |
Related Complexes