hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13615.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LIX1L | LIX1-like protein | 2 | UniProt NCBI |
| CAPN8 | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) | 4 | UniProt NCBI |
| CAPN2 | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | 5 | UniProt NCBI |
| CAPN1 | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | 5 | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | 5 | UniProt NCBI |
| CAST | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | 5 | UniProt NCBI |
| KDM8 | Bifunctional peptidase and arginyl-hydroxylase JMJD5 (EC 1.14.11.73) (EC 3.4.-.-) (JmjC domain-containing protein 5) (Jumonji C domain-containing protein 5) (L-arginine (3R)-hydroxylase KDM8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1474228 | 6.85992153937e-06 | 0.666666666667 | CAPN8 CAPNS1 CAST CAPN1 | Degradation of the extracellular matrix |
| REAC:R-HSA-8862803 | 9.37394499108e-06 | 0.5 | CAPN1 CAST CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 9.37394499108e-06 | 0.5 | CAPN1 CAST CAPNS1 | Neurodegenerative Diseases |
| REAC:R-HSA-9734009 | 1.42587173715e-05 | 0.5 | CAPN1 CAST CAPNS1 | Defective Intrinsic Pathway for Apoptosis |
| CORUM:6710 | 1.70876175213e-05 | 0.333333333333 | CAPN1 CAPNS1 | Calpain 1 |
| REAC:R-HSA-1474244 | 0.000155242509846 | 0.666666666667 | CAPN8 CAPNS1 CAST CAPN1 | Extracellular matrix organization |
| GO:0004198 | 0.000316805542726 | 0.5 | CAPN8 CAPNS1 CAPN1 | calcium-dependent cysteine-type endopeptidase activity |
| REAC:R-HSA-9645723 | 0.00084703415394 | 0.5 | CAPN1 CAST CAPNS1 | Diseases of programmed cell death |
| KEGG:05131 | 0.00369808394071 | 0.5 | CAPN1 CAST CAPNS1 | Shigellosis |
| WP:WP185 | 0.0346027913493 | 0.333333333333 | CAPN1 CAPNS1 | Integrin mediated cell adhesion |
| GO:0110158 | 0.042122686785 | 0.333333333333 | CAPN1 CAPNS1 | calpain complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CAST | CAPN1 | 1.0 | 0.144 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| CAPN1 | CAPNS1 | 1.0 | 0.604 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CAST | CAPN8 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAST | CAPNS1 | 0.997 | 0.186 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KDM8 | CAPN8 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CAPN8 | CAPN1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPN2 | CAPNS1 | 0.987 | 0.336 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CAPN8 | CAPNS1 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPN2 | CAPN1 | 0.963 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| CAST | LIX1L | 0.959 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only |
| CAST | CAPN2 | 0.707 | 0.142 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| LIX1L | CAPNS1 | 0.641 | 0.038 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| LIX1L | CAPN1 | 0.577 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only |
| CAPN8 | CAPN2 | 0.56 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KDM8 | CAST | 0.332 | 0.086 | bioplex3_WMM WMM_only |
| LIX1L | CAPN2 | 0.101 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| KDM8 | CAPN1 | 0.045 | 0.17 | bioplex3_WMM WMM_only |
| KDM8 | CAPNS1 | 0.028 | 0.11 | bioplex3_WMM WMM_only |
| KDM8 | CAPN2 | 0.006 | 0.12 | bioplex3_WMM WMM_only |
Related Complexes