hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13616.1
Complex Portal: CPX-21628
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FANCB | Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95) | 5 | UniProt NCBI |
| FANCL | E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) (RING-type E3 ubiquitin transferase FANCL) | 5 | UniProt NCBI |
| CDH16 | Cadherin-16 (Kidney-specific cadherin) (Ksp-cadherin) | 5 | UniProt NCBI |
| ANO9 | Anoctamin-9 (Transmembrane protein 16J) (Tumor protein p53-inducible protein 5) (p53-induced gene 5 protein) | 5 | UniProt NCBI |
| FANCC | Fanconi anemia group C protein (Protein FACC) | 5 | UniProt NCBI |
| GRK7 | Rhodopsin kinase GRK7 (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7) | 5 | UniProt NCBI |
| IL6R | Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)] | 5 | UniProt NCBI |
| ANO4 | Anoctamin-4 (Transmembrane protein 16D) | 5 | UniProt NCBI |
| FAAP100 | Fanconi anemia core complex-associated protein 100 (Fanconi anemia-associated protein of 100 kDa) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1624 | 3.76336611262e-10 | 0.444444444444 | FANCC FAAP100 FANCB FANCL | FA core complex (Fanconi anemia core complex) |
| CORUM:245 | 3.76336611262e-10 | 0.444444444444 | FANCC FAAP100 FANCB FANCL | FA core complex (Fanconi anemia core complex) |
| CORUM:6884 | 6.77220415489e-10 | 0.444444444444 | FANCC FAAP100 FANCB FANCL | Fanconi anemia FAAP100 complex |
| CORUM:6885 | 1.31072783286e-08 | 0.333333333333 | FAAP100 FANCB FANCL | L-B-P100 subcomplex |
| CORUM:1152 | 4.58189849981e-07 | 0.333333333333 | FANCC FANCB FANCL | FA complex (Fanconi anemia complex) |
| KEGG:03460 | 7.01558516497e-07 | 0.444444444444 | FANCC FAAP100 FANCB FANCL | Fanconi anemia pathway |
| REAC:R-HSA-6783310 | 8.15761533179e-07 | 0.444444444444 | FANCC FAAP100 FANCB FANCL | Fanconi Anemia Pathway |
| CORUM:2739 | 1.56948544187e-06 | 0.333333333333 | FANCC FANCB FANCL | FA complex (Fanconi anemia complex) |
| GO:0043240 | 1.6375274005e-06 | 0.444444444444 | FANCC FAAP100 FANCB FANCL | Fanconi anaemia nuclear complex |
| WP:WP4946 | 3.78060926198e-05 | 0.444444444444 | FANCC FAAP100 FANCB FANCL | DNA repair pathways full network |
| GO:0036297 | 0.000134592174076 | 0.444444444444 | FANCC FAAP100 FANCB FANCL | interstrand cross-link repair |
| HP:0005522 | 0.000224754750534 | 0.333333333333 | FANCC FANCB FANCL | Pyridoxine-responsive sideroblastic anemia |
| HP:0010469 | 0.000258388312027 | 0.333333333333 | FANCC FANCB FANCL | Absent testis |
| HP:0003974 | 0.000295209923159 | 0.333333333333 | FANCC FANCB FANCL | Absent radius |
| HP:0009822 | 0.000335362435482 | 0.333333333333 | FANCC FANCB FANCL | Aplasia involving forearm bones |
| HP:0003953 | 0.000335362435482 | 0.333333333333 | FANCC FANCB FANCL | Absent forearm bone |
| CORUM:1625 | 0.000409911647195 | 0.222222222222 | FANCB FANCC | FA core complex (Fanconi anemia core complex) |
| HP:0100867 | 0.00042623067938 | 0.333333333333 | FANCC FANCB FANCL | Duodenal stenosis |
| HP:0012848 | 0.00042623067938 | 0.333333333333 | FANCC FANCB FANCL | Small intestinal stenosis |
| HP:0010293 | 0.00042623067938 | 0.333333333333 | FANCC FANCB FANCL | Aplasia/Hypoplasia of the uvula |
| HP:0100760 | 0.0004772312239 | 0.333333333333 | FANCC FANCB FANCL | Clubbing of toes |
| HP:0002245 | 0.0004772312239 | 0.333333333333 | FANCC FANCB FANCL | Meckel diverticulum |
| GO:0006513 | 0.000488457397695 | 0.444444444444 | FANCC FAAP100 FANCB FANCL | protein monoubiquitination |
| HP:0100587 | 0.000591075857043 | 0.333333333333 | FANCC FANCB FANCL | Abnormal preputium morphology |
| HP:0001924 | 0.000721657409044 | 0.333333333333 | FANCC FANCB FANCL | Sideroblastic anemia |
| CORUM:248 | 0.000982845681582 | 0.222222222222 | FANCL FANCC | BRAFT complex |
| HP:0001549 | 0.00112875806168 | 0.333333333333 | FANCC FANCB FANCL | Abnormal ileum morphology |
| CORUM:244 | 0.00150061080904 | 0.222222222222 | FANCL FANCC | BRAFT complex |
| HP:0000813 | 0.00205632010064 | 0.333333333333 | FANCC FANCB FANCL | Bicornuate uterus |
| HP:0007874 | 0.00250410252496 | 0.333333333333 | FANCC FANCB FANCL | Almond-shaped palpebral fissure |
| HP:0100026 | 0.00266659082239 | 0.333333333333 | FANCC FANCB FANCL | Arteriovenous malformation |
| REAC:R-HSA-9733458 | 0.00286935042585 | 0.222222222222 | ANO9 ANO4 | Induction of Cell-Cell Fusion |
| HP:0003022 | 0.00301223952387 | 0.333333333333 | FANCC FANCB FANCL | Hypoplasia of the ulna |
| HP:0003220 | 0.00319567627268 | 0.333333333333 | FANCC FANCB FANCL | Abnormality of chromosome stability |
| HP:0200005 | 0.00338637189189 | 0.333333333333 | FANCC FANCB FANCL | Abnormal shape of the palpebral fissure |
| HP:0009777 | 0.00338637189189 | 0.333333333333 | FANCC FANCB FANCL | Absent thumb |
| HP:0006495 | 0.00379009050824 | 0.333333333333 | FANCC FANCB FANCL | Aplasia/Hypoplasia of the ulna |
| HP:0007565 | 0.00422449516114 | 0.333333333333 | FANCC FANCB FANCL | Multiple cafe-au-lait spots |
| REAC:R-HSA-73894 | 0.00517868236837 | 0.444444444444 | FANCC FAAP100 FANCB FANCL | DNA Repair |
| HP:0001199 | 0.00600237677255 | 0.333333333333 | FANCC FANCB FANCL | Triphalangeal thumb |
| HP:0000072 | 0.00658840376054 | 0.333333333333 | FANCC FANCB FANCL | Hydroureter |
| HP:0009821 | 0.00787159478799 | 0.333333333333 | FANCC FANCB FANCL | Forearm undergrowth |
| HP:0006501 | 0.0082163340983 | 0.333333333333 | FANCC FANCB FANCL | Aplasia/Hypoplasia of the radius |
| HP:0008572 | 0.00969509588682 | 0.333333333333 | FANCC FANCB FANCL | External ear malformation |
| HP:0009380 | 0.0100904083719 | 0.333333333333 | FANCC FANCB FANCL | Aplasia of the fingers |
| HP:0002246 | 0.0113399794078 | 0.333333333333 | FANCC FANCB FANCL | Abnormal duodenum morphology |
| HP:0009824 | 0.0113399794078 | 0.333333333333 | FANCC FANCB FANCL | Upper limb undergrowth |
| HP:0005344 | 0.0122273883855 | 0.333333333333 | FANCC FANCB FANCL | Abnormal carotid artery morphology |
| HP:0002575 | 0.0141374598912 | 0.333333333333 | FANCC FANCB FANCL | Tracheoesophageal fistula |
| HP:0000027 | 0.0151622418484 | 0.333333333333 | FANCC FANCB FANCL | Azoospermia |
| HP:0006503 | 0.0156925316576 | 0.333333333333 | FANCC FANCB FANCL | Aplasia/hypoplasia involving forearm bones |
| HP:0012745 | 0.0237358509345 | 0.333333333333 | FANCC FANCB FANCL | Short palpebral fissure |
| HP:0009892 | 0.0238199336716 | 0.222222222222 | FANCB FANCL | Anotia |
| HP:0008669 | 0.0274350409379 | 0.333333333333 | FANCC FANCB FANCL | Abnormal spermatogenesis |
| HP:0002863 | 0.0274350409379 | 0.333333333333 | FANCC FANCB FANCL | Myelodysplasia |
| HP:0001053 | 0.0282177129725 | 0.333333333333 | FANCC FANCB FANCL | Hypopigmented skin patches |
| HP:0010161 | 0.0282177129725 | 0.333333333333 | FANCC FANCB FANCL | Abnormal toe phalanx morphology |
| HP:0003221 | 0.0320448157979 | 0.222222222222 | FANCL FANCC | Chromosomal breakage induced by crosslinking agents |
| HP:0000957 | 0.03235230965 | 0.333333333333 | FANCC FANCB FANCL | Cafe-au-lait spot |
| HP:0008055 | 0.0332243721088 | 0.333333333333 | FANCC FANCB FANCL | Aplasia/Hypoplasia affecting the uvea |
| HP:0008053 | 0.0332243721088 | 0.333333333333 | FANCC FANCB FANCL | Aplasia/Hypoplasia of the iris |
| HP:0000453 | 0.0332243721088 | 0.333333333333 | FANCC FANCB FANCL | Choanal atresia |
| HP:0002414 | 0.0341117801001 | 0.333333333333 | FANCC FANCB FANCL | Spina bifida |
| HP:0001217 | 0.0350146609279 | 0.333333333333 | FANCC FANCB FANCL | Clubbing |
| HP:0008517 | 0.0366109494459 | 0.222222222222 | FANCB FANCL | Aplasia/Hypoplasia of the sacrum |
| HP:0000415 | 0.0407639834225 | 0.333333333333 | FANCC FANCB FANCL | Abnormality of the choanae |
| HP:0008062 | 0.0417787245797 | 0.333333333333 | FANCC FANCB FANCL | Aplasia/Hypoplasia affecting the anterior segment of the eye |
| HP:0000324 | 0.0428099509923 | 0.333333333333 | FANCC FANCB FANCL | Facial asymmetry |
| HP:0010301 | 0.0438577884627 | 0.333333333333 | FANCC FANCB FANCL | Spinal dysraphism |
| HP:0009601 | 0.0449223626268 | 0.333333333333 | FANCC FANCB FANCL | Aplasia/Hypoplasia of the thumb |
| HP:0002023 | 0.0460037989547 | 0.333333333333 | FANCC FANCB FANCL | Anal atresia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IL6R | ANO4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FANCL | FAAP100 | 0.995 | 0.175 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| ANO4 | ANO9 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FAAP100 | FANCB | 0.994 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| FANCL | FANCC | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FANCB | FANCC | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FANCL | FANCB | 0.991 | 0.226 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| GRK7 | FAAP100 | 0.988 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CDH16 | FANCL | 0.975 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| IL6R | FANCL | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IL6R | FANCB | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IL6R | ANO9 | 0.902 | bioplex3_WMM WMM_only | ||
| IL6R | FAAP100 | 0.811 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes