hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13617.1
Complex Portal: CPX-19116
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZBTB33 | Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) | 5 | UniProt NCBI |
| CGA | Glycoprotein hormones alpha chain (Anterior pituitary glycoprotein hormones common subunit alpha) (Choriogonadotropin alpha chain) (Chorionic gonadotrophin subunit alpha) (CG-alpha) (Follicle-stimulating hormone alpha chain) (FSH-alpha) (Follitropin alpha chain) (Luteinizing hormone alpha chain) (LSH-alpha) (Lutropin alpha chain) (Thyroid-stimulating hormone alpha chain) (TSH-alpha) (Thyrotropin alpha chain) | 5 | UniProt NCBI |
| MTMR12 | Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein) | 5 | UniProt NCBI |
| TRIML2 | Probable E3 ubiquitin-protein ligase TRIML2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIML2) (SPRY domain-containing protein 6) (Tripartite motif family-like protein 2) | 5 | UniProt NCBI |
| MTM1 | Myotubularin (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | 5 | UniProt NCBI |
| PTPN9 | Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1660516 | 0.00270466310657 | 0.333333333333 | MTMR12 MTM1 | Synthesis of PIPs at the early endosome membrane |
| WP:WP4971 | 0.00861234767009 | 0.333333333333 | MTMR12 MTM1 | Phosphoinositides metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ZBTB33 | TRIML2 | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | ||
| MTM1 | TRIML2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PTPN9 | MTM1 | 0.983 | 0.074 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| CGA | MTMR12 | 0.962 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MTM1 | CGA | 0.962 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MTM1 | ZBTB33 | 0.184 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| MTM1 | MTMR12 | 0.16 | 0.158 |
structurally_consistent (dimer)
|
bioplex3_WMM fraction |
| MTMR12 | ZBTB33 | 0.027 | 0.088 | bioplex3_WMM WMM_only | |
| PTPN9 | ZBTB33 | 0.01 | 0.054 | gupta_WMM WMM_only |
Related Complexes