hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13622.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TDG | G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG) | 5 | UniProt NCBI |
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | 5 | UniProt NCBI |
| SUMO3 | Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3065676 | 6.81752388431e-05 | 0.666666666667 | SAE1 SUMO3 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-3065678 | 0.000102258192243 | 0.666666666667 | SAE1 SUMO3 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 0.00024538606603 | 0.666666666667 | SAE1 SUMO3 | Processing and activation of SUMO |
| REAC:R-HSA-2990846 | 0.000330616079734 | 1.0 | SUMO3 TDG SAE1 | SUMOylation |
| REAC:R-HSA-3108214 | 0.0168905285744 | 0.666666666667 | TDG SUMO3 | SUMOylation of DNA damage response and repair proteins |
| HPA:0570813 | 0.0443510461782 | 1.0 | SUMO3 TDG SAE1 | testis; spermatogonia cells[High] |
| CORUM:5756 | 0.0499402709677 | 0.333333333333 | SAE1 | SUA1-UBA2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SAE1 | SUMO3 | 0.928 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM fraction |
| SUMO3 | TDG | 0.894 | 0.092 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes