hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13623.1

Complex Portal: CPX-20464

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
SMAD3	Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)	5	UniProt NCBI
SMAD2	Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)	5	UniProt NCBI
ACO1	Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)	5	UniProt NCBI
SMAD9	Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9)	5	UniProt NCBI
SMAD5	Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)	5	UniProt NCBI
TMEM192	Transmembrane protein 192	5	UniProt NCBI
SYPL2	Synaptophysin-like protein 2	4	UniProt NCBI
SEMA4A	Semaphorin-4A (Semaphorin-B) (Sema B)	5	UniProt NCBI
GAS7	Growth arrest-specific protein 7 (GAS-7)	5	UniProt NCBI
LEMD3	Inner nuclear membrane protein Man1 (LEM domain-containing protein 3)	5	UniProt NCBI
ZFYVE9	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP560	8.25185839203e-09	0.454545454545	SMAD9 ZFYVE9 SMAD3 SMAD5 SMAD2	TGF beta receptor signaling
WP:WP4816	1.04663315673e-08	0.454545454545	SMAD9 ZFYVE9 SMAD3 SMAD5 SMAD2	TGF beta receptor signaling in skeletal dysplasias
CORUM:1827	8.42140472852e-08	0.272727272727	ZFYVE9 SMAD3 SMAD2	PML-SMAD2/3-SARA complex
KEGG:04350	1.52344299184e-07	0.454545454545	SMAD9 ZFYVE9 SMAD3 SMAD5 SMAD2	TGF-beta signaling pathway
GO:0071141	3.03561565333e-07	0.363636363636	SMAD9 SMAD3 SMAD5 SMAD2	SMAD protein complex
GO:0071144	3.03561565333e-07	0.363636363636	SMAD9 SMAD3 SMAD5 SMAD2	heteromeric SMAD protein complex
WP:WP4331	6.44908668798e-07	0.363636363636	SMAD9 SMAD3 SMAD5 SMAD2	Neovascularisation processes
GO:0070411	1.18026398065e-05	0.363636363636	SMAD9 SMAD3 SMAD5 SMAD2	I-SMAD binding
WP:WP5353	2.0305159451e-05	0.363636363636	SMAD9 SMAD3 SMAD5 SMAD2	A network map of Macrophage stimulating protein MSP signaling
GO:0007179	2.24813307021e-05	0.545454545455	SMAD9 ZFYVE9 LEMD3 SMAD2 SMAD5 SMAD3	transforming growth factor beta receptor signaling pathway
CORUM:6513	3.41979277617e-05	0.181818181818	SMAD2 LEMD3	MAN1-SMAD2 complex
GO:0071560	4.99147242765e-05	0.545454545455	SMAD9 ZFYVE9 LEMD3 SMAD2 SMAD5 SMAD3	cellular response to transforming growth factor beta stimulus
GO:0071559	5.94619697955e-05	0.545454545455	SMAD9 ZFYVE9 LEMD3 SMAD2 SMAD5 SMAD3	response to transforming growth factor beta
KEGG:04550	6.95402311979e-05	0.363636363636	SMAD9 SMAD3 SMAD5 SMAD2	Signaling pathways regulating pluripotency of stem cells
CORUM:2830	0.000102551658964	0.181818181818	SMAD3 SMAD2	TIF1gamma-SMAD2-SMAD3 complex
CORUM:2834	0.000102551658964	0.181818181818	SMAD3 SMAD2	SMAD4-SMAD2-SMAD3 complex
REAC:R-HSA-9006936	0.000231665446959	0.363636363636	SMAD9 SMAD3 SMAD5 SMAD2	Signaling by TGFB family members
GO:0141091	0.000242291982993	0.545454545455	SMAD9 ZFYVE9 LEMD3 SMAD2 SMAD5 SMAD3	transforming growth factor beta receptor superfamily signaling pathway
WP:WP4535	0.000275329785577	0.272727272727	SMAD3 LEMD3 SMAD2	Envelope proteins and their potential roles in EDMD physiopathology
GO:0007178	0.000332748907759	0.545454545455	SMAD9 ZFYVE9 LEMD3 SMAD2 SMAD5 SMAD3	transmembrane receptor protein serine/threonine kinase signaling pathway
REAC:R-HSA-3304347	0.000400110876685	0.181818181818	SMAD3 SMAD2	Loss of Function of SMAD4 in Cancer
REAC:R-HSA-3311021	0.000400110876685	0.181818181818	SMAD3 SMAD2	SMAD4 MH2 Domain Mutants in Cancer
REAC:R-HSA-3315487	0.000400110876685	0.181818181818	SMAD3 SMAD2	SMAD2/3 MH2 Domain Mutants in Cancer
WP:WP4879	0.00052726211165	0.272727272727	SMAD3 LEMD3 SMAD2	Overlap between signal transduction pathways contributing to LMNA laminopathies
REAC:R-HSA-3656532	0.000799893187683	0.181818181818	SMAD3 SMAD2	TGFBR1 KD Mutants in Cancer
REAC:R-HSA-3304356	0.000799893187683	0.181818181818	SMAD3 SMAD2	SMAD2/3 Phosphorylation Motif Mutants in Cancer
CORUM:2829	0.00122759131257	0.181818181818	SMAD3 SMAD2	RSmad complex
REAC:R-HSA-3304349	0.00133260792819	0.181818181818	SMAD3 SMAD2	Loss of Function of SMAD2/3 in Cancer
REAC:R-HSA-3656534	0.00133260792819	0.181818181818	SMAD3 SMAD2	Loss of Function of TGFBR1 in Cancer
REAC:R-HSA-3304351	0.00199809115254	0.181818181818	SMAD3 SMAD2	Signaling by TGF-beta Receptor Complex in Cancer
WP:WP3876	0.00241126491604	0.181818181818	SMAD9 SMAD5	BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation
GO:0046332	0.00312623068186	0.363636363636	SMAD9 SMAD3 SMAD5 SMAD2	SMAD binding
WP:WP5382	0.00353361833038	0.181818181818	SMAD3 SMAD2	TGF Smad signaling pathway
GO:0060395	0.00386939458835	0.363636363636	SMAD9 SMAD3 SMAD5 SMAD2	SMAD protein signal transduction
HP:0008419	0.00476283944706	0.181818181818	SMAD3 SMAD2	Intervertebral disc degeneration
REAC:R-HSA-9823730	0.00478951429206	0.181818181818	SMAD3 SMAD2	Formation of definitive endoderm
REAC:R-HSA-9796292	0.00478951429206	0.181818181818	SMAD3 SMAD2	Formation of axial mesoderm
WP:WP3874	0.00561474372017	0.181818181818	SMAD3 SMAD2	Canonical and non canonical TGF B signaling
WP:WP3859	0.00561474372017	0.181818181818	SMAD3 SMAD2	TGF beta signaling in thyroid cells for epithelial mesenchymal transition
REAC:R-HSA-1502540	0.005984434688	0.181818181818	SMAD3 SMAD2	Signaling by Activin
WP:WP366	0.00864376547704	0.272727272727	ZFYVE9 SMAD3 SMAD2	TGF beta signaling pathway
REAC:R-HSA-9754189	0.00876996466453	0.181818181818	SMAD3 SMAD2	Germ layer formation at gastrulation
WP:WP5103	0.00912900259179	0.181818181818	SMAD3 SMAD2	Progeria associated lipodystrophy
GO:0071363	0.00922782272058	0.545454545455	SMAD9 ZFYVE9 LEMD3 SMAD2 SMAD5 SMAD3	cellular response to growth factor stimulus
WP:WP2895	0.0112018513551	0.181818181818	SMAD9 SMAD5	Differentiation of white and brown adipocyte
GO:0070848	0.0112703811132	0.545454545455	SMAD9 ZFYVE9 LEMD3 SMAD2 SMAD5 SMAD3	response to growth factor
HP:0000987	0.0137043884914	0.272727272727	SMAD3 LEMD3 SMAD2	Atypical scarring of skin
WP:WP3668	0.0147043059059	0.181818181818	SMAD3 SMAD2	Hypothesized pathways in pathogenesis of cardiovascular disease
REAC:R-HSA-9617828	0.0159192181681	0.181818181818	SMAD3 SMAD2	FOXO-mediated transcription of cell cycle genes
HP:0005086	0.0171180788587	0.181818181818	SMAD3 SMAD2	Knee osteoarthritis
HP:0100718	0.0171180788587	0.181818181818	SMAD3 SMAD2	Uterine rupture
WP:WP2870	0.0201054514571	0.181818181818	SMAD3 SMAD2	Extracellular vesicle mediated signaling in recipient cells
REAC:R-HSA-1181150	0.020280338984	0.181818181818	SMAD3 SMAD2	Signaling by NODAL
GO:0030509	0.0205202050386	0.363636363636	SMAD9 SMAD2 LEMD3 SMAD5	BMP signaling pathway
WP:WP3850	0.0231182298902	0.181818181818	SMAD3 SMAD2	Factors and pathways affecting insulin like growth factor IGF1 Akt signaling
KEGG:05321	0.0233077837061	0.181818181818	SMAD3 SMAD2	Inflammatory bowel disease
GO:0071772	0.0234558852507	0.363636363636	SMAD9 SMAD2 LEMD3 SMAD5	response to BMP
GO:0071773	0.0234558852507	0.363636363636	SMAD9 SMAD2 LEMD3 SMAD5	cellular response to BMP stimulus
KEGG:04144	0.0298442204102	0.272727272727	ZFYVE9 SMAD3 SMAD2	Endocytosis
HP:0008843	0.031344503338	0.181818181818	SMAD3 SMAD2	Hip osteoarthritis
HP:0005294	0.031344503338	0.181818181818	SMAD3 SMAD2	Arterial dissection
HP:0100699	0.032194928133	0.272727272727	SMAD3 LEMD3 SMAD2	Scarring
REAC:R-HSA-2173788	0.0334666719879	0.181818181818	SMAD3 SMAD2	Downregulation of TGF-beta receptor signaling
REAC:R-HSA-201451	0.0396512197609	0.181818181818	SMAD9 SMAD5	Signaling by BMP
REAC:R-HSA-9615017	0.0396512197609	0.181818181818	SMAD3 SMAD2	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
WP:WP1971	0.0412834882198	0.181818181818	SMAD3 SMAD2	Integrated cancer pathway
GO:0032924	0.0459347760023	0.272727272727	SMAD3 LEMD3 SMAD2	activin receptor signaling pathway
CORUM:3733	0.049976851631	0.0909090909091	SMAD3	SKI-SMAD3 complex
CORUM:3729	0.049976851631	0.0909090909091	SMAD2	SKI-SMAD2 complex
CORUM:3199	0.049976851631	0.0909090909091	SMAD3	SKI-SMAD3 complex
CORUM:3198	0.049976851631	0.0909090909091	SMAD2	SKI-SMAD2 complex
CORUM:3039	0.049976851631	0.0909090909091	SMAD2	SMAD2-FAST1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
SMAD3	LEMD3	0.999	0.124		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
SMAD9	LEMD3	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ZFYVE9	SMAD2	0.998	0.088	mutually_exclusive (Q99717)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
SMAD2	LEMD3	0.997	0.076		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
ZFYVE9	SMAD3	0.996	0.212	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
TMEM192	SEMA4A	0.994	0.02		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SMAD2	SMAD3	0.993	0.29	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SMAD3	SMAD9	0.989		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TMEM192	LEMD3	0.988	0.136		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TMEM192	SYPL2	0.984			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SEMA4A	LEMD3	0.97	0.088		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SMAD5	LEMD3	0.967	0.07		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
SMAD2	SMAD9	0.965		mutually_exclusive (P84022)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
TMEM192	SMAD5	0.909	0.066		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
ZFYVE9	GAS7	0.902	0.044		bioplex_WMM bioplex3_WMM WMM_only
ZFYVE9	LEMD3	0.841	0.09		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
SMAD9	ACO1	0.835			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_HCT116
ZFYVE9	SMAD9	0.353		mutually_exclusive (P84022)	bioplex_WMM bioplex3_WMM WMM_only
SMAD3	TMEM192	0.208	0.098		bioplex3_HEK293 bioplex3_WMM WMM_only
SMAD3	SMAD5	0.206	0.2		bioplex_WMM bioplex3_WMM WMM_only
SMAD2	SMAD5	0.102	0.094	structurally_consistent (dimer)	bioplex3_WMM WMM_only
LEMD3	SYPL2	0.095			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SMAD2	TMEM192	0.032	0.07		bioplex3_WMM WMM_only
TMEM192	ACO1	0.009	0.048		bioplex_WMM bioplex3_WMM WMM_only
LEMD3	ACO1	0.004	0.094		bioplex_WMM WMM_only

Related Complexes

Genename	Complexes
SMAD3	huMAP3_00500.1 huMAP3_00785.1 huMAP3_05180.1 huMAP3_09080.1 huMAP3_11389.1 huMAP3_13623.1 huMAP3_14587.1
SMAD2	huMAP3_00500.1 huMAP3_00785.1 huMAP3_05180.1 huMAP3_09080.1 huMAP3_11389.1 huMAP3_12636.1 huMAP3_13623.1 huMAP3_14587.1
ACO1	huMAP3_05161.1 huMAP3_10716.1 huMAP3_11389.1 huMAP3_12414.1 huMAP3_13623.1 huMAP3_14587.1
SMAD9	huMAP3_00785.1 huMAP3_02949.1 huMAP3_05180.1 huMAP3_09080.1 huMAP3_11389.1 huMAP3_13623.1 huMAP3_14587.1
SMAD5	huMAP3_02949.1 huMAP3_03070.1 huMAP3_09080.1 huMAP3_12701.1 huMAP3_13623.1 huMAP3_14109.1
TMEM192	huMAP3_00939.1 huMAP3_02450.1 huMAP3_06447.1 huMAP3_10923.1 huMAP3_13623.1
SYPL2	huMAP3_03777.1 huMAP3_10314.1 huMAP3_13197.1 huMAP3_13623.1 huMAP3_13921.1
SEMA4A	huMAP3_00939.1 huMAP3_02450.1 huMAP3_02847.1 huMAP3_02949.1 huMAP3_06447.1 huMAP3_09080.1 huMAP3_10923.1 huMAP3_13112.1 huMAP3_13623.1 huMAP3_14587.1
GAS7	huMAP3_03325.1 huMAP3_08945.1 huMAP3_10301.1 huMAP3_11389.1 huMAP3_13447.1 huMAP3_13623.1 huMAP3_14587.1 huMAP3_15340.1
LEMD3	huMAP3_02949.1 huMAP3_09080.1 huMAP3_10923.1 huMAP3_13623.1 huMAP3_14587.1
ZFYVE9	huMAP3_00020.1 huMAP3_00500.1 huMAP3_05180.1 huMAP3_06304.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09080.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_11389.1 huMAP3_13623.1 huMAP3_14504.1 huMAP3_14587.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13623.1

Complex Portal: CPX-20464