hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13637.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TNRC6C | Trinucleotide repeat-containing gene 6C protein | 5 | UniProt NCBI |
| AGO3 | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | 5 | UniProt NCBI |
| AGO2 | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | 5 | UniProt NCBI |
| AGO1 | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | 5 | UniProt NCBI |
| AGO4 | Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 6.13935741343e-16 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-8948700 | 1.63716197691e-15 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-9768778 | 1.63716197691e-15 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Regulation of NPAS4 mRNA translation |
| REAC:R-HSA-8943723 | 3.68361444806e-15 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Regulation of PTEN mRNA translation |
| REAC:R-HSA-9768759 | 7.36722889611e-15 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Regulation of NPAS4 gene expression |
| REAC:R-HSA-8934593 | 1.80906398449e-13 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-9634815 | 2.87321926948e-12 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Transcriptional Regulation by NPAS4 |
| REAC:R-HSA-9022692 | 3.47180661729e-12 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 4.9673540832e-12 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| REAC:R-HSA-9024446 | 1.68322762204e-11 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | NR1H2 and NR1H3-mediated signaling |
| REAC:R-HSA-426486 | 5.38065562428e-11 | 0.8 | AGO3 AGO4 AGO2 AGO1 | Small interfering RNA (siRNA) biogenesis |
| GO:0035278 | 5.57191707223e-11 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | miRNA-mediated gene silencing by inhibition of translation |
| REAC:R-HSA-8986944 | 8.38953422807e-11 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-4086398 | 8.38953422807e-11 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Ca2+ pathway |
| REAC:R-HSA-1912408 | 5.40112599599e-10 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-5628897 | 6.58885046645e-10 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-5687128 | 7.49048263554e-10 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912422 | 1.43769507313e-09 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-203927 | 3.77850578875e-09 | 0.8 | AGO3 AGO4 AGO2 AGO1 | MicroRNA (miRNA) biogenesis |
| REAC:R-HSA-211000 | 5.11506228649e-09 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Gene Silencing by RNA |
| REAC:R-HSA-9018519 | 7.43247491702e-09 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Estrogen-dependent gene expression |
| GO:0035195 | 8.66760864559e-09 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | miRNA-mediated post-transcriptional gene silencing |
| GO:0070578 | 9.20740386965e-09 | 0.8 | AGO3 AGO4 AGO2 AGO1 | RISC-loading complex |
| REAC:R-HSA-6807070 | 1.01357948373e-08 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | PTEN Regulation |
| REAC:R-HSA-3858494 | 1.05226572357e-08 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Beta-catenin independent WNT signaling |
| GO:0010501 | 1.65724193228e-08 | 0.8 | AGO3 AGO4 AGO2 AGO1 | RNA secondary structure unwinding |
| REAC:R-HSA-2559585 | 1.74513507793e-08 | 0.8 | AGO3 AGO4 TNRC6C AGO1 | Oncogene Induced Senescence |
| GO:0035194 | 2.58397654225e-08 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | regulatory ncRNA-mediated post-transcriptional gene silencing |
| GO:0070922 | 2.76191861336e-08 | 0.8 | AGO3 AGO4 AGO2 AGO1 | RISC complex assembly |
| REAC:R-HSA-8853884 | 2.81603526855e-08 | 0.8 | AGO3 AGO4 TNRC6C AGO1 | Transcriptional Regulation by VENTX |
| GO:0016441 | 4.91775888057e-08 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | post-transcriptional gene silencing |
| REAC:R-HSA-8939211 | 4.99934353244e-08 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | ESR-mediated signaling |
| REAC:R-HSA-157118 | 8.1926802348e-08 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Signaling by NOTCH |
| REAC:R-HSA-8878171 | 9.71413406998e-08 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Transcriptional regulation by RUNX1 |
| GO:0031332 | 1.31622611039e-07 | 0.8 | AGO3 AGO4 AGO2 AGO1 | RNAi effector complex |
| GO:0016442 | 1.31622611039e-07 | 0.8 | AGO3 AGO4 AGO2 AGO1 | RISC complex |
| REAC:R-HSA-1257604 | 1.50091064658e-07 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006931 | 2.15038697685e-07 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Signaling by Nuclear Receptors |
| REAC:R-HSA-5683057 | 2.23960562292e-07 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | MAPK family signaling cascades |
| GO:0031054 | 2.39287617466e-07 | 0.8 | AGO3 AGO4 AGO2 AGO1 | pre-miRNA processing |
| REAC:R-HSA-9006925 | 3.06527698566e-07 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Intracellular signaling by second messengers |
| GO:0031047 | 4.9426018149e-07 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | regulatory ncRNA-mediated gene silencing |
| REAC:R-HSA-195721 | 5.44261361409e-07 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Signaling by WNT |
| REAC:R-HSA-8936459 | 6.72765558294e-07 | 0.8 | AGO3 AGO4 TNRC6C AGO1 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| GO:0017148 | 7.88255587491e-07 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | negative regulation of translation |
| REAC:R-HSA-3700989 | 1.04327674985e-06 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Transcriptional Regulation by TP53 |
| GO:0034249 | 1.79000621904e-06 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | negative regulation of amide metabolic process |
| REAC:R-HSA-2559580 | 2.19193882479e-06 | 0.8 | AGO3 AGO4 TNRC6C AGO1 | Oxidative Stress Induced Senescence |
| GO:1902555 | 4.13351489328e-06 | 0.8 | AGO3 AGO4 AGO2 AGO1 | endoribonuclease complex |
| GO:0035198 | 4.13351489328e-06 | 0.8 | AGO3 AGO4 AGO2 AGO1 | miRNA binding |
| GO:1905348 | 6.87695434453e-06 | 0.8 | AGO3 AGO4 AGO2 AGO1 | endonuclease complex |
| GO:0035196 | 9.69325556185e-06 | 0.8 | AGO3 AGO4 AGO2 AGO1 | miRNA processing |
| GO:0061980 | 1.08004637014e-05 | 0.8 | AGO3 AGO4 AGO2 AGO1 | regulatory RNA binding |
| REAC:R-HSA-2559583 | 1.59752917105e-05 | 0.8 | AGO3 AGO4 TNRC6C AGO1 | Cellular Senescence |
| GO:0006402 | 2.46149880859e-05 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | mRNA catabolic process |
| GO:0036464 | 2.71638125757e-05 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | cytoplasmic ribonucleoprotein granule |
| GO:0035770 | 4.04570212314e-05 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | ribonucleoprotein granule |
| GO:0070918 | 4.47449753489e-05 | 0.8 | AGO3 AGO4 AGO2 AGO1 | regulatory ncRNA processing |
| GO:0003725 | 4.81842507515e-05 | 0.8 | AGO3 AGO4 AGO2 AGO1 | double-stranded RNA binding |
| GO:0006401 | 6.75947155719e-05 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | RNA catabolic process |
| GO:0006417 | 9.80554055735e-05 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | regulation of translation |
| GO:0003727 | 0.00010676760833 | 0.8 | AGO3 AGO4 AGO2 AGO1 | single-stranded RNA binding |
| GO:0034248 | 0.000225409707527 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | regulation of amide metabolic process |
| REAC:R-HSA-212436 | 0.000272959661036 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.000473207077014 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | RNA Polymerase II Transcription |
| GO:0034655 | 0.000668354304441 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | nucleobase-containing compound catabolic process |
| GO:0010608 | 0.000703431456203 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | post-transcriptional regulation of gene expression |
| REAC:R-HSA-74160 | 0.000887298860527 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Gene expression (Transcription) |
| GO:0046700 | 0.000946108360196 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | heterocycle catabolic process |
| GO:0044270 | 0.000957507256102 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | cellular nitrogen compound catabolic process |
| GO:0019439 | 0.00101616163427 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | aromatic compound catabolic process |
| GO:1901361 | 0.00122344493327 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | organic cyclic compound catabolic process |
| GO:0006412 | 0.00325815516493 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | translation |
| GO:0043043 | 0.00377641193976 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | peptide biosynthetic process |
| GO:0016071 | 0.00384557561421 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | mRNA metabolic process |
| GO:0051248 | 0.00443616857366 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | negative regulation of protein metabolic process |
| REAC:R-HSA-2262752 | 0.00463311209834 | 0.8 | AGO3 AGO4 TNRC6C AGO1 | Cellular responses to stress |
| GO:0090624 | 0.00468200720083 | 0.4 | AGO3 AGO2 | endoribonuclease activity, cleaving miRNA-paired mRNA |
| REAC:R-HSA-8953897 | 0.00481362685522 | 0.8 | AGO3 AGO4 TNRC6C AGO1 | Cellular responses to stimuli |
| GO:0022618 | 0.00628821134931 | 0.8 | AGO3 AGO4 AGO2 AGO1 | protein-RNA complex assembly |
| GO:0071826 | 0.00760417677557 | 0.8 | AGO3 AGO4 AGO2 AGO1 | protein-RNA complex organization |
| REAC:R-HSA-162582 | 0.00823431736973 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | Signal Transduction |
| GO:0043604 | 0.00918533309693 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | amide biosynthetic process |
| GO:0006518 | 0.00983194280049 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | peptide metabolic process |
| GO:0010629 | 0.0164267222964 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | negative regulation of gene expression |
| GO:0004521 | 0.0250826699056 | 0.6 | AGO3 AGO2 AGO4 | RNA endonuclease activity |
| GO:0099080 | 0.0373995595185 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | supramolecular complex |
| GO:0043603 | 0.0398244546538 | 1.0 | AGO3 AGO4 AGO1 TNRC6C AGO2 | amide metabolic process |
| CORUM:1386 | 0.0498708842806 | 0.2 | AGO4 | TTP-AGO4 complex |
| CORUM:1387 | 0.0498708842806 | 0.2 | AGO2 | TTP-AGO2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AGO1 | AGO2 | 0.993 | 0.212 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| AGO3 | AGO1 | 0.99 | 0.288 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| AGO3 | AGO2 | 0.976 | 0.268346153846 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| TNRC6C | AGO1 | 0.969 | 0.242171075838 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction |
| AGO3 | AGO4 | 0.968 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM WMM_only | |
| AGO4 | AGO1 | 0.94 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM WMM_only | |
| AGO4 | AGO2 | 0.814 | bioplex3_HEK293 bioplex3_WMM youn_WMM treiber_WMM WMM_only | |
| TNRC6C | AGO2 | 0.734 | 0.13 | youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| TNRC6C | AGO4 | 0.594 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| TNRC6C | AGO3 | 0.239 | 0.08 | youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
Related Complexes