hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13639.1
Complex Portal: CPX-16487
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KLHL28 | Kelch-like protein 28 (BTB/POZ domain-containing protein 5) | 2 | UniProt NCBI |
| PADI6 | Protein-arginine deiminase type-6 (EC 3.5.3.15) (Peptidyl arginine deiminase-like protein) (Peptidylarginine deiminase VI) (hPADVI) (Protein-arginine deiminase type VI) | 5 | UniProt NCBI |
| ZBTB3 | Zinc finger and BTB domain-containing protein 3 | 3 | UniProt NCBI |
| KBTBD4 | Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4) | 4 | UniProt NCBI |
| BTBD7 | BTB/POZ domain-containing protein 7 | 4 | UniProt NCBI |
| ADAD2 | Adenosine deaminase domain-containing protein 2 (Testis nuclear RNA-binding protein-like) | 4 | UniProt NCBI |
| KLHL12 | Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR) | 5 | UniProt NCBI |
| KLHL9 | Kelch-like protein 9 | 5 | UniProt NCBI |
| FBXL17 | F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) | 5 | UniProt NCBI |
| IPP | Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Kelch-like protein 27) | 4 | UniProt NCBI |
| CCIN | Calicin | 4 | UniProt NCBI |
| NUDCD3 | NudC domain-containing protein 3 | 5 | UniProt NCBI |
| KLHL13 | Kelch-like protein 13 (BTB and kelch domain-containing protein 2) | 5 | UniProt NCBI |
| KLHL21 | Kelch-like protein 21 | 5 | UniProt NCBI |
| KLHL26 | Kelch-like protein 26 | 5 | UniProt NCBI |
| KIRREL2 | Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3) | 5 | UniProt NCBI |
| CUL3 | Cullin-3 (CUL-3) | 5 | UniProt NCBI |
| KLHL14 | Kelch-like protein 14 (Protein interactor of Torsin-1A) (Printor) (Protein interactor of torsinA) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7523 | 2.52817954936e-07 | 0.166666666667 | KLHL9 CUL3 KLHL13 | Ubiquitin E3 ligase (CUL3, KLHL9, KLHL13, RBX1) |
| GO:0031463 | 4.33124926153e-05 | 0.277777777778 | KLHL12 KLHL13 KLHL21 CUL3 KLHL9 | Cul3-RING ubiquitin ligase complex |
| CORUM:6815 | 5.77699275587e-05 | 0.111111111111 | KLHL12 CUL3 | DRD4-KLHL12-CUL3 complex |
| CORUM:7522 | 0.000346113734644 | 0.111111111111 | KLHL12 CUL3 | Ubiquitin E3 ligase (CUL3, KLHL12, PEF1, PDCD6) |
| GO:0031461 | 0.00180967891172 | 0.333333333333 | KLHL13 FBXL17 KLHL9 KLHL12 KLHL21 CUL3 | cullin-RING ubiquitin ligase complex |
| KEGG:04120 | 0.0334243267251 | 0.166666666667 | KLHL9 CUL3 KLHL13 | Ubiquitin mediated proteolysis |
| GO:0000151 | 0.0343766952643 | 0.333333333333 | KLHL13 FBXL17 KLHL9 KLHL12 KLHL21 CUL3 | ubiquitin ligase complex |
| REAC:R-HSA-8951664 | 0.0435962472838 | 0.222222222222 | KLHL9 KLHL21 CUL3 KLHL13 | Neddylation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| IPP | KLHL28 | 0.999 | ||
| NUDCD3 | KLHL28 | 0.999 |
structurally_consistent (Q53HC5)
|
|
| BTBD7 | KLHL14 | 0.999 | ||
| KLHL13 | KLHL28 | 0.999 |
structurally_consistent (dimer)
|
|
| KLHL21 | KLHL28 | 0.999 | ||
| KLHL14 | KLHL28 | 0.998 | ||
| KLHL26 | KLHL28 | 0.998 |
structurally_consistent (dimer)
|
|
| KLHL26 | KLHL14 | 0.998 | ||
| KLHL13 | KLHL9 | 0.998 | 0.19 |
structurally_consistent (dimer)
|
| NUDCD3 | KLHL26 | 0.998 | 0.068 |
structurally_consistent (dimer)
|
| KLHL9 | KLHL28 | 0.998 |
structurally_consistent (dimer)
|
|
| FBXL17 | KLHL28 | 0.997 | ||
| KLHL14 | KBTBD4 | 0.996 | ||
| KLHL13 | CUL3 | 0.996 | 0.176230769231 |
structurally_consistent (dimer)
|
| NUDCD3 | KBTBD4 | 0.996 | 0.148 | |
| NUDCD3 | KLHL14 | 0.995 | ||
| NUDCD3 | KLHL9 | 0.995 | 0.105 | |
| FBXL17 | NUDCD3 | 0.995 | 0.086 | |
| IPP | KLHL9 | 0.993 | ||
| FBXL17 | KBTBD4 | 0.992 | 0.128 | |
| CUL3 | KLHL9 | 0.991 | 0.2 |
structurally_consistent (dimer)
|
| FBXL17 | KLHL9 | 0.989 | 0.082 | |
| NUDCD3 | CUL3 | 0.987 | 0.13925 | |
| CUL3 | KLHL28 | 0.984 |
structurally_consistent (dimer)
|
|
| KLHL21 | CUL3 | 0.984 | 0.158 |
structurally_consistent (Q9P2J3)
structurally_consistent (dimer) |
| KLHL12 | KLHL14 | 0.982 | ||
| KLHL26 | KLHL9 | 0.981 | 0.098 |
structurally_consistent (dimer)
|
| FBXL17 | KLHL13 | 0.981 | 0.106 | |
| KLHL12 | KLHL26 | 0.98 | 0.164 | |
| FBXL17 | KLHL14 | 0.979 | ||
| KLHL13 | KLHL14 | 0.976 | ||
| IPP | KLHL26 | 0.976 |
structurally_consistent (dimer)
|
|
| IPP | CUL3 | 0.974 |
structurally_consistent (Q53HC5)
structurally_consistent (dimer) |
|
| IPP | NUDCD3 | 0.973 | ||
| KLHL26 | CUL3 | 0.971 | 0.172 |
structurally_consistent (Q9P2J3)
structurally_consistent (dimer) |
| CCIN | NUDCD3 | 0.954 | ||
| KLHL21 | KLHL9 | 0.95 | 0.148 |
structurally_consistent (dimer)
|
| KLHL21 | KLHL13 | 0.95 | 0.166 | |
| PADI6 | KLHL28 | 0.946 | ||
| KLHL26 | KLHL13 | 0.945 | 0.088 | |
| NUDCD3 | ADAD2 | 0.939 | ||
| CUL3 | KBTBD4 | 0.933 | 0.446 |
structurally_consistent (dimer)
|
| KIRREL2 | KLHL13 | 0.928 | ||
| KLHL9 | KLHL14 | 0.919 | ||
| KIRREL2 | KLHL9 | 0.919 | ||
| KLHL21 | KLHL14 | 0.912 | ||
| KLHL12 | FBXL17 | 0.908 | 0.122 | |
| BTBD7 | KBTBD4 | 0.902 | ||
| FBXL17 | KLHL26 | 0.901 | 0.136 | |
| IPP | KLHL14 | 0.901 | ||
| KLHL12 | CUL3 | 0.884 | 0.207333333333 |
structurally_consistent (dimer)
|
| FBXL17 | IPP | 0.858 | ||
| KLHL26 | KBTBD4 | 0.817 | 0.12 | |
| KLHL21 | IPP | 0.803 | ||
| KLHL21 | KLHL26 | 0.785 | 0.09 | |
| FBXL17 | CUL3 | 0.745 | 0.086 | |
| BTBD7 | KLHL28 | 0.703 | ||
| KLHL12 | KLHL28 | 0.676 |
mutually_exclusive (Q13618)
|
|
| KLHL21 | NUDCD3 | 0.667 | 0.072 | |
| KBTBD4 | KLHL28 | 0.651 | ||
| KLHL21 | FBXL17 | 0.644 | 0.116 | |
| IPP | KBTBD4 | 0.572 | ||
| IPP | KLHL13 | 0.501 | ||
| KLHL12 | KLHL9 | 0.472 | 0.124 |
mutually_exclusive (Q13618)
|
| FBXL17 | BTBD7 | 0.468 | ||
| IPP | BTBD7 | 0.468 | ||
| KLHL12 | IPP | 0.464 |
mutually_exclusive (Q13618)
|
|
| KLHL12 | KLHL13 | 0.428 | 0.174 |
mutually_exclusive (Q13618)
|
| KLHL21 | BTBD7 | 0.418 | ||
| KLHL21 | KLHL12 | 0.418 | 0.102 |
mutually_exclusive (Q13618)
|
| NUDCD3 | KLHL13 | 0.296 | 0.038 | |
| KLHL21 | KBTBD4 | 0.28 | 0.178 |
mutually_exclusive (Q13618)
|
| KLHL12 | NUDCD3 | 0.267 | 0.156 | |
| KLHL26 | BTBD7 | 0.22 | ||
| NUDCD3 | BTBD7 | 0.22 | ||
| KLHL13 | BTBD7 | 0.16 | ||
| KIRREL2 | CUL3 | 0.147 | ||
| KLHL12 | KBTBD4 | 0.134 | 0.064 |
mutually_exclusive (Q13618)
|
| KLHL9 | BTBD7 | 0.12 | ||
| KLHL12 | BTBD7 | 0.116 | ||
| KLHL13 | KBTBD4 | 0.106 | 0.184 | |
| KLHL9 | KBTBD4 | 0.088 | 0.092 | |
| CUL3 | KLHL14 | 0.073 | ||
| PADI6 | CUL3 | 0.035 | ||
| CUL3 | BTBD7 | 0.013 | ||
| KLHL12 | CCIN | 0.004 |
Related Complexes