hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13648.1
Complex Portal: CPX-15595
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INTS3 | Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) | 5 | UniProt NCBI |
| DIAPH3 | Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) | 5 | UniProt NCBI |
| TXLNG | Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5) | 5 | UniProt NCBI |
| INIP | SOSS complex subunit C (INTS3- and NABP-interacting protein) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (SOSS-C) (Single-stranded DNA-binding protein-interacting protein 1) (SSB-interacting protein 1) (hSSBIP1) | 5 | UniProt NCBI |
| NABP2 | SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1) | 5 | UniProt NCBI |
| USP28 | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | 5 | UniProt NCBI |
| NABP1 | SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2) | 5 | UniProt NCBI |
| INTS6L | Integrator complex subunit 6-like (Protein DDX26B) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070876 | 1.84188417064e-09 | 0.5 | NABP1 INIP INTS3 NABP2 | SOSS complex |
| GO:0010212 | 1.63146572742e-05 | 0.625 | NABP1 INIP USP28 INTS3 NABP2 | response to ionizing radiation |
| GO:0044818 | 0.000297812763465 | 0.5 | NABP1 INIP INTS3 NABP2 | mitotic G2/M transition checkpoint |
| GO:0000075 | 0.00045612716804 | 0.625 | NABP1 INIP USP28 INTS3 NABP2 | cell cycle checkpoint signaling |
| GO:0010972 | 0.00062119716087 | 0.5 | NABP1 INIP INTS3 NABP2 | negative regulation of G2/M transition of mitotic cell cycle |
| GO:1902750 | 0.00071915484071 | 0.5 | NABP1 INIP INTS3 NABP2 | negative regulation of cell cycle G2/M phase transition |
| GO:1901988 | 0.00133227426114 | 0.625 | NABP1 INIP USP28 INTS3 NABP2 | negative regulation of cell cycle phase transition |
| REAC:R-HSA-6807505 | 0.00134205528321 | 0.375 | NABP2 INTS3 NABP1 | RNA polymerase II transcribes snRNA genes |
| GO:0035861 | 0.002326053637 | 0.5 | NABP1 INIP INTS3 NABP2 | site of double-strand break |
| GO:0010948 | 0.00289341488904 | 0.625 | NABP1 INIP USP28 INTS3 NABP2 | negative regulation of cell cycle process |
| GO:0010389 | 0.00301307308056 | 0.5 | NABP1 INIP INTS3 NABP2 | regulation of G2/M transition of mitotic cell cycle |
| GO:0010564 | 0.00374962654073 | 0.75 | NABP2 INIP TXLNG USP28 INTS3 NABP1 | regulation of cell cycle process |
| GO:0009314 | 0.00433782741441 | 0.625 | NABP1 INIP USP28 INTS3 NABP2 | response to radiation |
| GO:1902749 | 0.00461836161062 | 0.5 | NABP1 INIP INTS3 NABP2 | regulation of cell cycle G2/M phase transition |
| GO:0090734 | 0.00766061600114 | 0.5 | NABP1 INIP INTS3 NABP2 | site of DNA damage |
| GO:0045786 | 0.00970046377374 | 0.625 | NABP1 INIP USP28 INTS3 NABP2 | negative regulation of cell cycle |
| GO:0000086 | 0.0100133115528 | 0.5 | NABP1 INIP INTS3 NABP2 | G2/M transition of mitotic cell cycle |
| GO:0044839 | 0.0142611443327 | 0.5 | NABP1 INIP INTS3 NABP2 | cell cycle G2/M phase transition |
| GO:0007093 | 0.0168296561278 | 0.5 | NABP1 INIP INTS3 NABP2 | mitotic cell cycle checkpoint signaling |
| GO:1901987 | 0.017751758579 | 0.625 | NABP1 INIP USP28 INTS3 NABP2 | regulation of cell cycle phase transition |
| GO:1901991 | 0.0306827893089 | 0.5 | NABP1 INIP INTS3 NABP2 | negative regulation of mitotic cell cycle phase transition |
| HPA:0060853 | 0.0364097382506 | 0.375 | INIP USP28 NABP2 | bronchus; ciliated cells (cell body)[High] |
| GO:0051726 | 0.0383655059594 | 0.75 | NABP2 INIP TXLNG USP28 INTS3 NABP1 | regulation of cell cycle |
| HPA:0320853 | 0.0414138493464 | 0.375 | INIP USP28 NABP2 | nasopharynx; ciliated cells (cell body)[High] |
| GO:0000724 | 0.0445000722229 | 0.5 | NABP1 INIP INTS3 NABP2 | double-strand break repair via homologous recombination |
| GO:0000725 | 0.0491838271735 | 0.5 | NABP1 INIP INTS3 NABP2 | recombinational repair |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NABP2 | INTS3 | 1.0 | 0.33 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction | |
| INIP | NABP2 | 1.0 | 0.282 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction | |
| INIP | INTS3 | 0.999 | 0.396 | hein_WMM bioplex_WMM bioplex3_WMM Malo fraction | |
| NABP2 | INTS6L | 0.978 | 0.056 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| INIP | DIAPH3 | 0.959 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| INTS3 | TXLNG | 0.932 | 0.086 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| USP28 | DIAPH3 | 0.923 | 0.138 | bioplex_WMM bioplex3_WMM WMM_only | |
| INIP | NABP1 | 0.921 | 0.308 | hein_WMM hein () | |
| NABP2 | USP28 | 0.918 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| INIP | USP28 | 0.895 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| INTS3 | NABP1 | 0.894 | 0.24 | hein_WMM hein () | |
| INTS3 | DIAPH3 | 0.892 | 0.098 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NABP2 | DIAPH3 | 0.891 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only | |
| INTS3 | USP28 | 0.885 | 0.056 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| INTS6L | INTS3 | 0.761 | 0.092 | bioplex3_WMM WMM_only | |
| INIP | INTS6L | 0.72 | 0.108 | bioplex3_WMM WMM_only | |
| TXLNG | DIAPH3 | 0.014 | 0.072 | youn_WMM gupta_WMM WMM_only | |
| TXLNG | USP28 | 0.006 | 0.054 | gupta_WMM WMM_only |
Related Complexes