hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13666.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NDUFAF8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 | 4 | UniProt NCBI |
| NDUFAF5 | Arginine-hydroxylase NDUFAF5, mitochondrial (EC 1.-.-.-) (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5) (Putative methyltransferase NDUFAF5) (EC 2.1.1.-) | 5 | UniProt NCBI |
| NPPB | Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: NT-proBNP (NT-pro-BNP) (NT-proBNP(1-76)); proBNP(3-108); Brain natriuretic peptide 32 (BNP(1-32)) (BNP-32) (Brain natriuretic peptide) (BNP); BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32) (des-SerPro-BNP) (proBNP(79-108)); BNP(3-30); BNP(3-29); Brain natriuretic peptide 29 (BNP(4-32)); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0012748 | 0.00180445241025 | 1.0 | NDUFAF8 NDUFAF5 | Focal T2 hyperintense brainstem lesion |
| HP:0007704 | 0.00215303980768 | 1.0 | NDUFAF8 NDUFAF5 | Paroxysmal involuntary eye movements |
| HP:0012747 | 0.00253238491666 | 1.0 | NDUFAF8 NDUFAF5 | Abnormal brainstem MRI signal intensity |
| HP:0008316 | 0.00253238491666 | 1.0 | NDUFAF8 NDUFAF5 | Abnormal mitochondria in muscle tissue |
| KEGG:04714 | 0.00339933231144 | 1.0 | NDUFAF8 NDUFAF5 | Thermogenesis |
| HP:0000114 | 0.0036943429081 | 1.0 | NDUFAF8 NDUFAF5 | Proximal tubulopathy |
| HP:0003542 | 0.00453163616665 | 1.0 | NDUFAF8 NDUFAF5 | Increased serum pyruvate |
| HP:0004366 | 0.00453163616665 | 1.0 | NDUFAF8 NDUFAF5 | Abnormality of glycolysis |
| HP:0001138 | 0.00470934738887 | 1.0 | NDUFAF8 NDUFAF5 | Optic neuropathy |
| HP:0003737 | 0.00489047613459 | 1.0 | NDUFAF8 NDUFAF5 | Mitochondrial myopathy |
| HP:0025116 | 0.00564916635254 | 1.0 | NDUFAF8 NDUFAF5 | Fetal distress |
| HP:0011013 | 0.00755614446791 | 1.0 | NDUFAF8 NDUFAF5 | Abnormal circulating carbohydrate concentration |
| HP:0003800 | 0.0107993742735 | 1.0 | NDUFAF8 NDUFAF5 | Muscle abnormality related to mitochondrial dysfunction |
| HP:0011923 | 0.0133830220427 | 1.0 | NDUFAF8 NDUFAF5 | Decreased activity of mitochondrial complex I |
| HP:0034435 | 0.0149379952371 | 1.0 | NDUFAF8 NDUFAF5 | Abnormal eye contact |
| HP:0002415 | 0.0149379952371 | 1.0 | NDUFAF8 NDUFAF5 | Leukodystrophy |
| HP:0000817 | 0.0149379952371 | 1.0 | NDUFAF8 NDUFAF5 | Reduced eye contact |
| HP:0000124 | 0.0152592424465 | 1.0 | NDUFAF8 NDUFAF5 | Renal tubular dysfunction |
| HP:0002490 | 0.0159119894358 | 1.0 | NDUFAF8 NDUFAF5 | Increased CSF lactate |
| HP:0030085 | 0.0159119894358 | 1.0 | NDUFAF8 NDUFAF5 | Abnormal CSF lactate concentration |
| HP:0000758 | 0.0169167413461 | 1.0 | NDUFAF8 NDUFAF5 | Abnormal nonverbal communicative behavior |
| HP:0008972 | 0.0277776310426 | 1.0 | NDUFAF8 NDUFAF5 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 0.0295479082178 | 1.0 | NDUFAF8 NDUFAF5 | Abnormal activity of mitochondrial respiratory chain |
| HP:0025454 | 0.0299990213204 | 1.0 | NDUFAF8 NDUFAF5 | Abnormal CSF metabolite concentration |
| HP:0032615 | 0.0499436884913 | 0.5 | NDUFAF8 | Abnormal diffusion weighted cerebral MRI morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NDUFAF5 | NDUFAF8 | 0.934 | 0.226 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| NPPB | NDUFAF5 | 0.867 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes