hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13674.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBL5 | Ubiquitin-like protein 5 | 5 | UniProt NCBI |
| IK | Protein Red (Cytokine IK) (IK factor) (Protein RER) | 5 | UniProt NCBI |
| SMU1 | WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed] | 5 | UniProt NCBI |
| WBP11 | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | 5 | UniProt NCBI |
| PQBP1 | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72163 | 7.60208852298e-08 | 1.0 | WBP11 SMU1 PQBP1 UBL5 IK | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 9.03664675283e-08 | 1.0 | WBP11 SMU1 PQBP1 UBL5 IK | mRNA Splicing |
| REAC:R-HSA-72203 | 3.62691640182e-07 | 1.0 | WBP11 SMU1 PQBP1 UBL5 IK | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-8953854 | 3.59450904867e-05 | 1.0 | WBP11 SMU1 PQBP1 UBL5 IK | Metabolism of RNA |
| CORUM:351 | 0.0011586928604 | 0.6 | WBP11 IK SMU1 | Spliceosome |
| HPA:0300413 | 0.0203515557622 | 0.8 | WBP11 PQBP1 IK SMU1 | lung; macrophages[High] |
| GO:0000377 | 0.0264444778619 | 0.8 | PQBP1 SMU1 UBL5 IK | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.0264444778619 | 0.8 | PQBP1 SMU1 UBL5 IK | mRNA splicing, via spliceosome |
| GO:0000375 | 0.0280745884658 | 0.8 | PQBP1 SMU1 UBL5 IK | RNA splicing, via transesterification reactions |
| KEGG:03040 | 0.0346393491085 | 0.4 | WBP11 PQBP1 | Spliceosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| WBP11 | PQBP1 | 1.0 | 0.868 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| SMU1 | IK | 0.998 | 0.954 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo fraction boldt_WMM treiber_WMM |
| UBL5 | PQBP1 | 0.969 | 0.068 | hein_WMM youn_WMM hein () |
| IK | PQBP1 | 0.952 | 0.824 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| SMU1 | PQBP1 | 0.944 | 0.64 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| WBP11 | IK | 0.874 | 0.814 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| IK | UBL5 | 0.52 | 0.204 | hein_WMM youn_WMM WMM_only |
| WBP11 | UBL5 | 0.515 | 0.028 | hein_WMM youn_WMM WMM_only |
| WBP11 | SMU1 | 0.279 | 0.812 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM |
| SMU1 | UBL5 | 0.116 | 0.242 | hein_WMM bioplex3_HEK293 bioplex () |
Related Complexes