hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13675.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM204 | Transmembrane protein 204 (Claudin-like protein 24) | 4 | UniProt NCBI |
| SLC8A1 | Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) | 5 | UniProt NCBI |
| ACVR1 | Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) | 5 | UniProt NCBI |
| ACVRL1 | Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I) | 5 | UniProt NCBI |
| BMPR2 | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | 5 | UniProt NCBI |
| FKBP1B | Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) (h-FKBP-12) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0098821 | 3.84302573496e-05 | 0.5 | ACVRL1 ACVR1 BMPR2 | BMP receptor activity |
| GO:0017002 | 0.00010757157937 | 0.5 | ACVRL1 ACVR1 BMPR2 | activin receptor activity |
| GO:0005024 | 0.000316805542726 | 0.5 | ACVRL1 ACVR1 BMPR2 | transforming growth factor beta receptor activity |
| GO:0004675 | 0.000698569295426 | 0.5 | ACVRL1 ACVR1 BMPR2 | transmembrane receptor protein serine/threonine kinase activity |
| GO:0001945 | 0.00130441648129 | 0.5 | TMEM204 BMPR2 ACVRL1 | lymph vessel development |
| KEGG:04060 | 0.00242349416029 | 0.5 | ACVRL1 ACVR1 BMPR2 | Cytokine-cytokine receptor interaction |
| GO:0060391 | 0.00627357313526 | 0.5 | ACVRL1 ACVR1 BMPR2 | positive regulation of SMAD protein signal transduction |
| GO:0070724 | 0.00702301080125 | 0.333333333333 | ACVRL1 ACVR1 | BMP receptor complex |
| REAC:R-HSA-201451 | 0.00771351163082 | 0.333333333333 | ACVRL1 BMPR2 | Signaling by BMP |
| GO:0030501 | 0.00777254411354 | 0.5 | SLC8A1 ACVR1 BMPR2 | positive regulation of bone mineralization |
| GO:0003197 | 0.00949259421943 | 0.5 | ACVRL1 ACVR1 BMPR2 | endocardial cushion development |
| GO:0045778 | 0.0114488243093 | 0.5 | SLC8A1 ACVR1 BMPR2 | positive regulation of ossification |
| GO:0070169 | 0.0136563164499 | 0.5 | SLC8A1 ACVR1 BMPR2 | positive regulation of biomineral tissue development |
| GO:0060390 | 0.0203731249082 | 0.5 | ACVRL1 ACVR1 BMPR2 | regulation of SMAD protein signal transduction |
| REAC:R-HSA-5578775 | 0.0210220699274 | 0.333333333333 | SLC8A1 FKBP1B | Ion homeostasis |
| GO:0072359 | 0.0257592307287 | 0.833333333333 | TMEM204 BMPR2 ACVRL1 ACVR1 SLC8A1 | circulatory system development |
| KEGG:04350 | 0.0267786555833 | 0.333333333333 | ACVR1 BMPR2 | TGF-beta signaling pathway |
| GO:0030500 | 0.0309610298034 | 0.5 | SLC8A1 ACVR1 BMPR2 | regulation of bone mineralization |
| GO:0016361 | 0.042122686785 | 0.333333333333 | ACVRL1 ACVR1 | activin receptor activity, type I |
| KEGG:05418 | 0.0483092600715 | 0.333333333333 | ACVR1 BMPR2 | Fluid shear stress and atherosclerosis |
| WP:WP3931 | 0.0489911417376 | 0.333333333333 | ACVR1 BMPR2 | Embryonic stem cell pluripotency pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ACVR1 | TMEM204 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACVR1 | SLC8A1 | 0.989 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ACVR1 | FKBP1B | 0.989 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| BMPR2 | ACVR1 | 0.988 | 0.176 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ACVR1 | ACVRL1 | 0.93 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FKBP1B | ACVRL1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC8A1 | ACVRL1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC8A1 | FKBP1B | 0.557 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only |
| BMPR2 | FKBP1B | 0.333 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only |
| BMPR2 | SLC8A1 | 0.333 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only |
| BMPR2 | ACVRL1 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes