hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13677.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TEAD4 | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | 5 | UniProt NCBI |
| IRF2 | Interferon regulatory factor 2 (IRF-2) | 5 | UniProt NCBI |
| IRF2BPL | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | 5 | UniProt NCBI |
| WWTR1 | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | 5 | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | 5 | UniProt NCBI |
| TEAD3 | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | 5 | UniProt NCBI |
| CTSS | Cathepsin S (EC 3.4.22.27) | 5 | UniProt NCBI |
| TEAD1 | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | 5 | UniProt NCBI |
| IRF2BP1 | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | 5 | UniProt NCBI |
| IRF2BP2 | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | 5 | UniProt NCBI |
| VGLL4 | Transcription cofactor vestigial-like protein 4 (Vgl-4) | 5 | UniProt NCBI |
| YAP1 | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 1.04992548215e-16 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | RUNX3 regulates YAP1-mediated transcription |
| REAC:R-HSA-2032785 | 3.46150205157e-15 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| WP:WP4537 | 4.13492043889e-14 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | Hippo YAP signaling |
| KEGG:04392 | 1.79203936448e-13 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | Hippo signaling pathway - multiple species |
| WP:WP4541 | 4.90945441501e-12 | 0.7 | YAP1 WWTR1 TEAD3 TEAD1 VGLL4 TEAD2 TEAD4 | Hippo Merlin signaling dysregulation |
| GO:0035329 | 5.70026207713e-12 | 0.7 | YAP1 WWTR1 TEAD3 TEAD1 VGLL4 TEAD2 TEAD4 | hippo signaling |
| WP:WP4534 | 5.82089743725e-12 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| WP:WP3967 | 1.94496067349e-11 | 0.5 | TEAD1 TEAD2 TEAD4 YAP1 TEAD3 | miR 509 3p alteration of YAP1 ECM axis |
| WP:WP4540 | 5.25795145525e-10 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | Hippo signaling regulation pathways |
| WP:WP4542 | 5.26827377139e-10 | 0.5 | TEAD1 TEAD2 TEAD4 YAP1 TEAD3 | Leukocyte intrinsic Hippo pathway functions |
| REAC:R-HSA-8878159 | 1.99421084432e-09 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | Transcriptional regulation by RUNX3 |
| KEGG:04390 | 9.17263048828e-09 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | Hippo signaling pathway |
| CORUM:6848 | 1.68385473419e-08 | 0.3 | IRF2BPL IRF2BP2 IRF2BP1 | IRF2BP2-IRF2BP1-IRF2BPL complex |
| WP:WP4533 | 3.31316415231e-08 | 0.4 | TEAD1 TEAD2 TEAD4 TEAD3 | Transcription co factors SKI and SKIL protein partners |
| WP:WP5087 | 7.23881444573e-08 | 0.7 | YAP1 WWTR1 TEAD3 TEAD1 VGLL4 TEAD2 TEAD4 | Pleural mesothelioma |
| REAC:R-HSA-9796292 | 4.67054604924e-06 | 0.3 | TEAD2 TEAD4 YAP1 | Formation of axial mesoderm |
| GO:0140552 | 1.15344049292e-05 | 0.3 | TEAD2 YAP1 TEAD1 | TEAD-YAP complex |
| CORUM:6651 | 3.07577115383e-05 | 0.2 | YAP1 WWTR1 | WWTR1-YAP1 complex |
| REAC:R-HSA-9619665 | 7.36319907643e-05 | 0.3 | TEAD1 WWTR1 YAP1 | EGR2 and SOX10-mediated initiation of Schwann cell myelination |
| REAC:R-HSA-9758941 | 0.000427697670043 | 0.3 | TEAD2 TEAD4 YAP1 | Gastrulation |
| GO:0006355 | 0.000478593942439 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | regulation of DNA-templated transcription |
| GO:2001141 | 0.00050846345131 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | regulation of RNA biosynthetic process |
| GO:0006351 | 0.000769096906474 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | DNA-templated transcription |
| GO:0032774 | 0.000855932930644 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | RNA biosynthetic process |
| GO:0051252 | 0.00146550722958 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | regulation of RNA metabolic process |
| GO:0006357 | 0.00189176803533 | 0.9 | YAP1 WWTR1 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | regulation of transcription by RNA polymerase II |
| GO:0034654 | 0.00300537391933 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | nucleobase-containing compound biosynthetic process |
| GO:0006366 | 0.00303820734058 | 0.9 | YAP1 WWTR1 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | transcription by RNA polymerase II |
| GO:0018130 | 0.00360676293504 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | heterocycle biosynthetic process |
| GO:0019438 | 0.00364529640625 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | aromatic compound biosynthetic process |
| GO:0019219 | 0.00365822298925 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | regulation of nucleobase-containing compound metabolic process |
| REAC:R-HSA-212436 | 0.00465548020126 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | Generic Transcription Pathway |
| GO:1901362 | 0.0048698369109 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | organic cyclic compound biosynthetic process |
| WP:WP2857 | 0.00723895082243 | 0.3 | TEAD2 YAP1 TEAD1 | Mesodermal commitment pathway |
| REAC:R-HSA-73857 | 0.0087488365386 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | RNA Polymerase II Transcription |
| GO:0140110 | 0.00942037447081 | 0.8 | YAP1 WWTR1 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 TEAD4 | transcription regulator activity |
| GO:0016070 | 0.0139641671754 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | RNA metabolic process |
| REAC:R-HSA-2028269 | 0.0172971739669 | 0.2 | YAP1 WWTR1 | Signaling by Hippo |
| REAC:R-HSA-74160 | 0.0179061878456 | 0.6 | YAP1 WWTR1 TEAD1 TEAD3 TEAD2 TEAD4 | Gene expression (Transcription) |
| REAC:R-HSA-8940973 | 0.0192120670931 | 0.2 | YAP1 WWTR1 | RUNX2 regulates osteoblast differentiation |
| GO:0010468 | 0.0204731292091 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | regulation of gene expression |
| GO:0044271 | 0.0220501553308 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | cellular nitrogen compound biosynthetic process |
| GO:0010556 | 0.0279393069327 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | regulation of macromolecule biosynthetic process |
| REAC:R-HSA-8941326 | 0.0302795201711 | 0.2 | YAP1 WWTR1 | RUNX2 regulates bone development |
| TF:M09760_1 | 0.031041584188 | 0.9 | YAP1 WWTR1 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | Factor: DPF2; motif: NYCACYTCCYCNYYCY; match class: 1 |
| REAC:R-HSA-1266738 | 0.032020162516 | 0.5 | TEAD1 TEAD2 TEAD4 YAP1 WWTR1 | Developmental Biology |
| GO:0031326 | 0.0348126464055 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | regulation of cellular biosynthetic process |
| GO:0009889 | 0.0369341229167 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | regulation of biosynthetic process |
| GO:0090304 | 0.0476672618515 | 1.0 | YAP1 WWTR1 VGLL4 TEAD1 IRF2BP2 TEAD3 IRF2BP1 TEAD2 IRF2BPL TEAD4 | nucleic acid metabolic process |
| CORUM:6652 | 0.0499436884912 | 0.1 | WWTR1 | WWTR1 homodimer |
| CORUM:7062 | 0.0499436884912 | 0.1 | WWTR1 | NFAT5-WWTR1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IRF2BP1 | IRF2BP2 | 1.0 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TEAD2 | TEAD1 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IRF2BPL | IRF2BP1 | 1.0 | 0.274 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| WWTR1 | TEAD1 | 1.0 | 0.15 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VGLL4 | TEAD3 | 1.0 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VGLL4 | IRF2BPL | 0.999 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| WWTR1 | TEAD4 | 0.999 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| IRF2BPL | IRF2BP2 | 0.999 | 0.074 | bioplex_WMM bioplex3_WMM Malo fraction |
| VGLL4 | IRF2BP2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VGLL4 | IRF2BP1 | 0.999 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| WWTR1 | TEAD2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD4 | TEAD1 | 0.999 | 0.38 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TEAD2 | YAP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD2 | TEAD4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TEAD3 | WWTR1 | 0.997 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| IRF2 | CTSS | 0.995 | 0.266 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IRF2BPL | IRF2 | 0.995 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| YAP1 | TEAD4 | 0.994 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| IRF2BP2 | IRF2 | 0.993 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VGLL4 | TEAD1 | 0.991 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VGLL4 | TEAD4 | 0.99 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| WWTR1 | YAP1 | 0.974 | 0.114 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| TEAD3 | TEAD1 | 0.925 | 0.254 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| YAP1 | TEAD1 | 0.923 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| TEAD3 | TEAD2 | 0.902 | bioplex3_WMM WMM_only | |
| TEAD3 | IRF2BPL | 0.884 | 0.022 | bioplex_WMM bioplex3_WMM WMM_only |
| TEAD3 | IRF2BP1 | 0.878 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
| TEAD3 | IRF2BP2 | 0.853 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only |
| IRF2BP1 | IRF2 | 0.838 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TEAD3 | TEAD4 | 0.829 | 0.21 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| TEAD3 | YAP1 | 0.813 | 0.094 | hein_WMM hein () |
| IRF2BPL | CTSS | 0.502 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only |
| VGLL4 | TEAD2 | 0.378 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP2 | CTSS | 0.35 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only |
| IRF2BP1 | CTSS | 0.333 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
| VGLL4 | WWTR1 | 0.215 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| VGLL4 | YAP1 | 0.196 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only |
| IRF2BPL | TEAD4 | 0.188 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only |
| IRF2BPL | TEAD1 | 0.188 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only |
| IRF2BP1 | TEAD4 | 0.17 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only |
| IRF2BP1 | TEAD1 | 0.163 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
| IRF2BP2 | TEAD1 | 0.14 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only |
| IRF2BP2 | TEAD4 | 0.109 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only |
| YAP1 | IRF2BP1 | 0.092 | 0.054 | bioplex3_WMM youn_WMM WMM_only |
| YAP1 | IRF2BPL | 0.055 | 0.026 | bioplex3_WMM WMM_only |
| YAP1 | IRF2BP2 | 0.043 | 0.138 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes