hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13688.1

Complex Portal: CPX-17950

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
TARS1	Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1)	5	UniProt NCBI
SDCCAG8	Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP)	5	UniProt NCBI
AIMP1	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)]	5	UniProt NCBI
KARS1	Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)	5	UniProt NCBI
LARS1	Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS)	5	UniProt NCBI
AIMP2	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1)	5	UniProt NCBI
EEF1E1	Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18)	5	UniProt NCBI
QARS1	Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)	5	UniProt NCBI
TARS3	Threonine--tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase protein 3)	5	UniProt NCBI
RARS1	Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)	5	UniProt NCBI
IARS1	Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)	5	UniProt NCBI
MARS1	Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)	5	UniProt NCBI
EPRS1	Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)]	5	UniProt NCBI
DARS1	Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:3040	3.28665753178e-32	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	Multisynthetase complex
GO:0017101	2.97142578029e-28	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	aminoacyl-tRNA synthetase multienzyme complex
REAC:R-HSA-379716	2.87465324335e-25	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	Cytosolic tRNA aminoacylation
REAC:R-HSA-379724	2.15188977692e-22	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	tRNA Aminoacylation
REAC:R-HSA-2408522	7.47279609189e-18	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	Selenoamino acid metabolism
KEGG:00970	7.17879682652e-17	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	Aminoacyl-tRNA biosynthesis
GO:0006418	2.3318613891e-14	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	tRNA aminoacylation for protein translation
GO:0004812	2.93291672476e-14	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	aminoacyl-tRNA ligase activity
GO:0016875	2.93291672476e-14	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	ligase activity, forming carbon-oxygen bonds
GO:0043039	4.55268726084e-14	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	tRNA aminoacylation
GO:0043038	4.55268726084e-14	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	amino acid activation
REAC:R-HSA-72766	1.30976085979e-13	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	Translation
REAC:R-HSA-71291	4.04828879939e-13	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	Metabolism of amino acids and derivatives
GO:0140101	1.78035658329e-10	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	catalytic activity, acting on a tRNA
GO:0016874	1.55925320267e-09	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	ligase activity
GO:0006399	9.81787949133e-09	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	tRNA metabolic process
CORUM:6189	2.5725558439e-08	0.25	QARS1 AIMP1 RARS1	ArgRS-GlnRS-AIMP1 complex
GO:0006520	2.84836866186e-08	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	amino acid metabolic process
GO:0140535	9.055777555e-07	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	intracellular protein-containing complex
GO:0140098	1.00430049224e-06	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	catalytic activity, acting on RNA
REAC:R-HSA-392499	6.66011767075e-06	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	Metabolism of proteins
HP:0002415	7.86994452412e-06	0.416666666667	EPRS1 RARS1 AIMP2 AIMP1 KARS1	Leukodystrophy
REAC:R-HSA-1430728	9.54512572104e-06	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	Metabolism
HPA:0250132	1.42373787034e-05	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	hippocampus; neuronal cells[>=Medium]
HP:0001263	2.26180401485e-05	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Global developmental delay
HP:0000252	2.48149285354e-05	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 RARS1 KARS1	Microcephaly
HP:0040195	2.69363869432e-05	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 RARS1 KARS1	Decreased head circumference
GO:0140640	3.53968525939e-05	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	catalytic activity, acting on a nucleic acid
GO:0034660	4.84890632588e-05	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	ncRNA metabolic process
HP:0012447	6.59825428682e-05	0.583333333333	EPRS1 AIMP2 QARS1 MARS1 AIMP1 RARS1 KARS1	Abnormal myelination
GO:0006412	6.75832566417e-05	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	translation
HPA:0100133	7.8298914595e-05	0.75	LARS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1	cerebral cortex; neuronal cells[High]
HPA:0250133	8.00155862109e-05	0.666666666667	LARS1 AIMP1 MARS1 IARS1 SDCCAG8 TARS3 RARS1 KARS1	hippocampus; neuronal cells[High]
GO:0043043	8.53003489535e-05	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	peptide biosynthetic process
HPA:0100132	9.03060992143e-05	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	cerebral cortex; neuronal cells[>=Medium]
HP:0007364	0.000108491434873	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 RARS1 KARS1	Aplasia/Hypoplasia of the cerebrum
HP:0000240	0.000119919290531	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 RARS1 KARS1	Abnormality of skull size
HP:0000929	0.000142510772053	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormal skull morphology
HP:0011400	0.000188047447933	0.5	EPRS1 AIMP2 QARS1 AIMP1 RARS1 KARS1	Abnormal CNS myelination
HP:0012758	0.000189886818294	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Neurodevelopmental delay
GO:0043604	0.000345466902291	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	amide biosynthetic process
HPA:0080132	0.000351536587435	0.916666666667	LARS1 AIMP2 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	caudate; neuronal cells[>=Medium]
GO:0006518	0.000384411086787	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	peptide metabolic process
HP:0009121	0.000394281913273	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormal axial skeleton morphology
HPA:0130201	0.000394574866845	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	colon; endothelial cells[>=Low]
GO:1902494	0.00041124907503	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 KARS1	catalytic complex
HPA:0050091	0.000450705343737	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	breast; myoepithelial cells[>=Low]
HP:0002977	0.000466481281128	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 RARS1 KARS1	Aplasia/Hypoplasia involving the central nervous system
HP:0001250	0.000614574097942	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 IARS1 SDCCAG8 RARS1 KARS1	Seizure
HP:0000007	0.000798194747636	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Autosomal recessive inheritance
HP:0003676	0.000825363271183	0.416666666667	EPRS1 QARS1 MARS1 AIMP1 AIMP2	Progressive
HP:0003011	0.000857107355389	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormality of the musculature
HP:0001257	0.000945186651152	0.583333333333	EPRS1 MARS1 AIMP1 IARS1 SDCCAG8 RARS1 KARS1	Spasticity
HPA:0080131	0.000976257350269	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	caudate; neuronal cells[>=Low]
HP:0012759	0.000982868916762	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Neurodevelopmental abnormality
HP:0002060	0.000999975493667	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 RARS1 KARS1	Abnormal cerebral morphology
HP:0100547	0.00114332538698	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 RARS1 KARS1	Abnormal forebrain morphology
HPA:0250131	0.00119223445267	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	hippocampus; neuronal cells[>=Low]
HP:0003808	0.00147830028574	0.75	LARS1 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormal muscle tone
HPA:0380521	0.0015638853581	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	placenta; trophoblastic cells[>=Low]
HPA:0540052	0.00157390488176	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	stomach 1; glandular cells[>=Medium]
HP:0011842	0.00163645661456	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormal skeletal morphology
HP:0025032	0.00211871645358	0.75	LARS1 AIMP2 EPRS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormality of digestive system physiology
HP:0000924	0.00220884949639	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormality of the skeletal system
HP:0000234	0.00249067279402	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormality of the head
HP:0000152	0.0027178751618	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormality of head or neck
HPA:0100131	0.0027870885536	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	cerebral cortex; neuronal cells[>=Low]
HPA:0030051	0.00317139684849	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	appendix; glandular cells[>=Low]
HPA:0250000	0.00334094833726	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	hippocampus
HP:0002167	0.00338433442281	0.666666666667	EPRS1 AIMP2 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormality of speech or vocalization
GO:0043603	0.00342715213249	0.666666666667	LARS1 EPRS1 QARS1 MARS1 IARS1 TARS3 RARS1 KARS1	amide metabolic process
HPA:0080000	0.00400984544365	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	caudate
HP:0007369	0.00408057446033	0.5	EPRS1 AIMP2 QARS1 AIMP1 RARS1 KARS1	Atrophy/Degeneration affecting the cerebrum
HP:0001276	0.00421075577734	0.583333333333	EPRS1 MARS1 AIMP1 IARS1 SDCCAG8 RARS1 KARS1	Hypertonia
HP:0034434	0.00422603188813	0.666666666667	EPRS1 AIMP2 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormal communication
WP:WP3925	0.00437471755022	0.25	RARS1 EPRS1 IARS1	Amino acid metabolism
HPA:0630000	0.00446622599574	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	cervix
HPA:0350471	0.00450999073941	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	pancreas; exocrine glandular cells[>=Low]
HPA:0400051	0.00509616291159	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	rectum; glandular cells[>=Low]
HP:0011804	0.00522648091025	0.75	LARS1 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormal muscle physiology
HP:0002493	0.00572504720435	0.583333333333	EPRS1 MARS1 AIMP1 IARS1 SDCCAG8 RARS1 KARS1	Upper motor neuron dysfunction
HPA:0090000	0.00611304905017	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	cerebellum
HP:0003593	0.00625608591667	0.583333333333	EPRS1 AIMP2 QARS1 MARS1 AIMP1 RARS1 KARS1	Infantile onset
HPA:0320000	0.00642208047467	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	nasopharynx
HP:0012443	0.00659651306191	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 RARS1 KARS1	Abnormal brain morphology
HPA:0630221	0.00676612098857	0.916666666667	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	cervix; squamous epithelial cells[>=Low]
HP:0001397	0.00699874593828	0.333333333333	LARS1 MARS1 SDCCAG8 IARS1	Hepatic steatosis
HPA:0050000	0.00707023341495	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	breast
HP:0006561	0.00734770461419	0.333333333333	LARS1 MARS1 SDCCAG8 IARS1	Lipid accumulation in hepatocytes
HP:0012444	0.008237659441	0.5	EPRS1 AIMP2 QARS1 AIMP1 RARS1 KARS1	Brain atrophy
HP:0012638	0.00838034346577	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormal nervous system physiology
HPA:0610831	0.00848686730658	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	urinary bladder; urothelial cells[>=Low]
HPA:0610000	0.00848686730658	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	urinary bladder
HP:0003679	0.00864441858669	0.416666666667	EPRS1 QARS1 MARS1 AIMP1 AIMP2	Pace of progression
HP:0033127	0.00872060405654	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormality of the musculoskeletal system
HP:0031137	0.00887376032095	0.333333333333	LARS1 MARS1 SDCCAG8 IARS1	Storage in hepatocytes
HPA:0350000	0.00935715589229	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	pancreas
HP:0034644	0.0110970502779	0.333333333333	LARS1 MARS1 SDCCAG8 IARS1	Abnormal liver metabolite concentration
HPA:0380000	0.0111649106631	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	placenta
HPA:0570801	0.011539878867	0.666666666667	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 EEF1E1 KARS1	testis; sertoli cells[>=Low]
HPA:0320101	0.0116137475713	0.916666666667	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 TARS3 KARS1	nasopharynx; respiratory epithelial cells[>=Low]
HPA:0550000	0.011870765722	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	stomach 2
HPA:0550051	0.011870765722	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	stomach 2; glandular cells[>=Low]
HP:0002011	0.0123674844051	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 RARS1 KARS1	Morphological central nervous system abnormality
HPA:0090191	0.0125791700971	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	cerebellum; cells in molecular layer[>=Low]
HPA:0540051	0.012753439821	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	stomach 1; glandular cells[>=Low]
HPA:0540000	0.012753439821	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	stomach 1
HPA:0220000	0.0133828278061	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	gallbladder
HPA:0220051	0.0133828278061	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	gallbladder; glandular cells[>=Low]
HP:0000707	0.0136732984129	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormality of the nervous system
HPA:0570751	0.0140920293344	0.583333333333	LARS1 AIMP2 EPRS1 MARS1 AIMP1 EEF1E1 KARS1	testis; elongated or late spermatids[>=Low]
HP:0007367	0.0146825740315	0.5	EPRS1 AIMP2 QARS1 AIMP1 RARS1 KARS1	Atrophy/Degeneration affecting the central nervous system
HP:0025031	0.014831265127	0.75	LARS1 AIMP2 EPRS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Abnormality of the digestive system
HPA:0030000	0.0157197532384	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	appendix
HP:0012639	0.015996267509	0.75	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 RARS1 KARS1	Abnormal nervous system morphology
HPA:0400000	0.0189759229557	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	rectum
HPA:0100000	0.0226077764091	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	cerebral cortex
HPA:0090192	0.0290038954755	0.666666666667	LARS1 AIMP2 EPRS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	cerebellum; cells in molecular layer[>=Medium]
HPA:0550052	0.02921812826	0.916666666667	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 EEF1E1 RARS1 TARS3 KARS1	stomach 2; glandular cells[>=Medium]
GO:0006425	0.0309012475255	0.166666666667	LARS1 QARS1	glutaminyl-tRNA aminoacylation
GO:0004819	0.0309012475255	0.166666666667	LARS1 QARS1	glutamine-tRNA ligase activity
HPA:0130000	0.0312231816795	1.0	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 TARS3 KARS1 EEF1E1	colon
HP:0003429	0.0323727565724	0.25	QARS1 EPRS1 RARS1	CNS hypomyelination
HP:0032243	0.0346163885867	0.333333333333	LARS1 MARS1 SDCCAG8 IARS1	Abnormal tissue metabolite concentration
REAC:R-HSA-379726	0.0349632924576	0.166666666667	QARS1 KARS1	Mitochondrial tRNA aminoacylation
HP:0001508	0.0440050797247	0.5	EPRS1 LARS1 MARS1 AIMP1 IARS1 KARS1	Failure to thrive
HP:0000750	0.0473387164531	0.5	AIMP2 MARS1 AIMP1 IARS1 SDCCAG8 KARS1	Delayed speech and language development
HP:0034345	0.0487788776415	0.833333333333	LARS1 AIMP2 EPRS1 QARS1 AIMP1 MARS1 IARS1 SDCCAG8 RARS1 KARS1	Mendelian inheritance

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
RARS1	DARS1	1.0	0.506
IARS1	DARS1	1.0	0.488
LARS1	MARS1	1.0	0.788
QARS1	RARS1	1.0	0.646
KARS1	AIMP2	1.0	0.644
IARS1	EPRS1	1.0	0.95	structurally_consistent (dimer)
RARS1	IARS1	1.0	0.538
QARS1	DARS1	1.0	0.508
LARS1	EPRS1	1.0	0.864
QARS1	MARS1	1.0	0.424
LARS1	IARS1	1.0	0.956
IARS1	MARS1	1.0	0.754
AIMP2	IARS1	1.0	0.702	structurally_consistent (dimer)
AIMP1	KARS1	1.0	0.462
RARS1	EPRS1	1.0	0.758
LARS1	RARS1	1.0	0.646
KARS1	RARS1	1.0	0.746
LARS1	DARS1	1.0	0.468
LARS1	QARS1	1.0	0.418
AIMP1	AIMP2	1.0	0.79
KARS1	MARS1	1.0	0.53
RARS1	MARS1	1.0	0.506
QARS1	IARS1	1.0	0.456
KARS1	EPRS1	1.0	0.712
AIMP2	EPRS1	1.0	0.836	structurally_consistent (P41252)
QARS1	EPRS1	1.0	0.464
KARS1	QARS1	1.0	0.476
AIMP2	RARS1	1.0	0.86
AIMP2	QARS1	1.0	0.58
KARS1	LARS1	1.0	0.496
KARS1	EEF1E1	0.999	0.668
MARS1	EPRS1	0.999	0.902
KARS1	IARS1	0.999	0.566
EPRS1	DARS1	0.999	0.475179487179
AIMP2	MARS1	0.999	0.76
KARS1	DARS1	0.999	0.394
AIMP2	DARS1	0.999	0.694
LARS1	AIMP2	0.999	0.572
AIMP1	EPRS1	0.999	0.672	structurally_consistent (P41252)
LARS1	TARS3	0.999	0.278
AIMP1	MARS1	0.999	0.784
KARS1	TARS3	0.999	0.228
AIMP2	EEF1E1	0.999	0.714
AIMP1	RARS1	0.999	0.87
AIMP1	EEF1E1	0.999	0.402
AIMP1	IARS1	0.999	0.486	structurally_consistent (dimer)
MARS1	DARS1	0.999	0.392
AIMP1	QARS1	0.999	0.83
EEF1E1	QARS1	0.999	0.204666666667
TARS3	IARS1	0.998	0.236
AIMP1	DARS1	0.998	0.814
EEF1E1	IARS1	0.998	0.752
AIMP1	LARS1	0.998	0.562
LARS1	EEF1E1	0.997	0.74
EEF1E1	RARS1	0.997	0.73
EEF1E1	EPRS1	0.997	0.6
AIMP1	TARS3	0.995	0.184	structurally_consistent (dimer)
EEF1E1	DARS1	0.994	0.327333333333
QARS1	TARS3	0.993	0.356
TARS3	RARS1	0.991	0.278
TARS1	AIMP1	0.99	0.296	structurally_consistent (A2RTX5)
EEF1E1	MARS1	0.99	0.916
TARS1	KARS1	0.989	0.358
SDCCAG8	IARS1	0.972	0.056
TARS3	EPRS1	0.967	0.18
TARS1	LARS1	0.963	0.544
TARS1	RARS1	0.955	0.346
SDCCAG8	LARS1	0.953	0.134
SDCCAG8	KARS1	0.946	0.122
TARS1	EPRS1	0.944	0.71825
SDCCAG8	QARS1	0.941	0.174
AIMP2	TARS3	0.935	0.116
TARS3	DARS1	0.934	0.25
TARS1	IARS1	0.921	0.592
TARS1	AIMP2	0.904	0.552
TARS3	MARS1	0.887	0.282
SDCCAG8	AIMP1	0.876	0.154
TARS1	TARS3	0.856	0.16	structurally_consistent (dimer)
SDCCAG8	EPRS1	0.848	0.212
SDCCAG8	RARS1	0.836	0.12
SDCCAG8	EEF1E1	0.78	0.074
TARS1	EEF1E1	0.77	0.458
TARS1	QARS1	0.758	0.244
EEF1E1	TARS3	0.74	0.07
SDCCAG8	AIMP2	0.737	0.128
SDCCAG8	DARS1	0.707	0.133
SDCCAG8	MARS1	0.703	0.12
TARS1	DARS1	0.655	0.502
TARS1	MARS1	0.266	0.518
SDCCAG8	TARS3	0.18	0.142
SDCCAG8	TARS1	0.066	0.08

Related Complexes

Genename	Complexes
TARS1	huMAP3_02637.1 huMAP3_08294.1 huMAP3_09382.1 huMAP3_12944.1 huMAP3_13688.1
SDCCAG8	huMAP3_01504.1 huMAP3_06860.1 huMAP3_10122.1 huMAP3_13688.1
AIMP1	huMAP3_02637.1 huMAP3_13688.1
KARS1	huMAP3_02637.1 huMAP3_13688.1
LARS1	huMAP3_02637.1 huMAP3_13688.1
AIMP2	huMAP3_02637.1 huMAP3_13688.1
EEF1E1	huMAP3_02637.1 huMAP3_13688.1
QARS1	huMAP3_02637.1 huMAP3_13688.1
TARS3	huMAP3_02637.1 huMAP3_11280.1 huMAP3_13688.1
RARS1	huMAP3_02637.1 huMAP3_13688.1
IARS1	huMAP3_02637.1 huMAP3_13688.1
MARS1	huMAP3_02637.1 huMAP3_13274.1 huMAP3_13688.1
EPRS1	huMAP3_02637.1 huMAP3_13688.1
DARS1	huMAP3_02637.1 huMAP3_13688.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13688.1

Complex Portal: CPX-17950