hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13695.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MTHFD1 | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | 5 | UniProt NCBI |
| PKM | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | 5 | UniProt NCBI |
| AK1 | Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.10) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase) | 5 | UniProt NCBI |
| GMPS | GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:01232 | 0.000392605812153 | 1.0 | AK1 GMPS | Nucleotide metabolism |
| KEGG:00230 | 0.000772693757832 | 1.0 | AK1 GMPS | Purine metabolism |
| REAC:R-HSA-15869 | 0.00499983688673 | 1.0 | AK1 GMPS | Metabolism of nucleotides |
| KEGG:00730 | 0.0284987925806 | 0.5 | AK1 | Thiamine metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GMPS | PKM | 0.919 | 0.43 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM fraction treiber_WMM |
| GMPS | AK1 | 0.868 | 0.038 | bioplex_WMM bioplex3_WMM youn_WMM fraction |
| PKM | MTHFD1 | 0.852 | 0.534 | bioplex_WMM bioplex3_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| GMPS | MTHFD1 | 0.829 | 0.274 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AK1 | PKM | 0.057 | 0.21 | bioplex_WMM bioplex3_WMM fraction treiber_WMM |
| AK1 | MTHFD1 | 0.025 | 0.062 | bioplex_WMM bioplex3_WMM youn_WMM fraction |
Related Complexes