hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13697.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IRAK2 | Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) | 5 | UniProt NCBI |
| GLOD4 | Glyoxalase domain-containing protein 4 | 4 | UniProt NCBI |
| SPOP | Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) | 5 | UniProt NCBI |
| TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2) | 5 | UniProt NCBI |
| MYD88 | Myeloid differentiation primary response protein MyD88 | 5 | UniProt NCBI |
| ARMCX6 | Protein ARMCX6 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4136 | 1.49788288335e-05 | 0.5 | MYD88 IRAK2 TIRAP | Fibrin complement receptor 3 signaling pathway |
| REAC:R-HSA-168188 | 0.000964479133971 | 0.5 | MYD88 IRAK2 TIRAP | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.000964479133971 | 0.5 | MYD88 IRAK2 TIRAP | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| KEGG:05152 | 0.000989019592829 | 0.5 | MYD88 IRAK2 TIRAP | Tuberculosis |
| REAC:R-HSA-181438 | 0.00102704788141 | 0.5 | MYD88 IRAK2 TIRAP | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.00102704788141 | 0.5 | MYD88 IRAK2 TIRAP | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-166016 | 0.00209955523641 | 0.5 | MYD88 IRAK2 TIRAP | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-5603041 | 0.002344469338 | 0.333333333333 | MYD88 TIRAP | IRAK4 deficiency (TLR2/4) |
| REAC:R-HSA-5602498 | 0.002344469338 | 0.333333333333 | MYD88 TIRAP | MyD88 deficiency (TLR2/4) |
| WP:WP3851 | 0.00301015088032 | 0.333333333333 | MYD88 TIRAP | TLR4 signaling and tolerance |
| REAC:R-HSA-168898 | 0.00323172543915 | 0.5 | MYD88 IRAK2 TIRAP | Toll-like Receptor Cascades |
| WP:WP3858 | 0.00352059040085 | 0.333333333333 | MYD88 TIRAP | Toll like receptor signaling related to MyD88 |
| WP:WP4496 | 0.00436073489596 | 0.333333333333 | MYD88 IRAK2 | Signal transduction through IL1R |
| REAC:R-HSA-5260271 | 0.00902151290218 | 0.333333333333 | MYD88 TIRAP | Diseases of Immune System |
| REAC:R-HSA-5602358 | 0.00902151290218 | 0.333333333333 | MYD88 TIRAP | Diseases associated with the TLR signaling cascade |
| WP:WP2637 | 0.00903081201495 | 0.333333333333 | MYD88 IRAK2 | Interleukin 1 IL 1 structural pathway |
| WP:WP195 | 0.0112707123684 | 0.333333333333 | MYD88 IRAK2 | IL 1 signaling pathway |
| KEGG:05133 | 0.0123104747863 | 0.333333333333 | MYD88 TIRAP | Pertussis |
| GO:0034142 | 0.0136563164499 | 0.5 | MYD88 IRAK2 TIRAP | toll-like receptor 4 signaling pathway |
| WP:WP2324 | 0.0176466803728 | 0.333333333333 | MYD88 TIRAP | AGE RAGE pathway |
| KEGG:05235 | 0.0226487502466 | 0.333333333333 | MYD88 TIRAP | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04064 | 0.0226487502466 | 0.333333333333 | MYD88 TIRAP | NF-kappa B signaling pathway |
| GO:0140895 | 0.0235785344663 | 0.5 | MYD88 IRAK2 TIRAP | cell surface toll-like receptor signaling pathway |
| KEGG:04620 | 0.0267786555833 | 0.333333333333 | MYD88 TIRAP | Toll-like receptor signaling pathway |
| WP:WP75 | 0.0337850948883 | 0.333333333333 | MYD88 TIRAP | Toll like receptor signaling pathway |
| GO:0002752 | 0.0351680546752 | 0.5 | MYD88 IRAK2 TIRAP | cell surface pattern recognition receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TIRAP | IRAK2 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYD88 | ARMCX6 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYD88 | TIRAP | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYD88 | SPOP | 0.962 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MYD88 | IRAK2 | 0.904 | bioplex3_WMM WMM_only | |
| MYD88 | GLOD4 | 0.825 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GLOD4 | SPOP | 0.003 | bioplex3_WMM WMM_only |
Related Complexes