hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13708.1
Complex Portal: CPX-18109
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS54 | Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) | 5 | UniProt NCBI |
| ENOPH1 | Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog) | 5 | UniProt NCBI |
| VPS52 | Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) | 5 | UniProt NCBI |
| VPS51 | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) | 5 | UniProt NCBI |
| GINS2 | DNA replication complex GINS protein PSF2 (GINS complex subunit 2) | 5 | UniProt NCBI |
| TXNDC2 | Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) | 5 | UniProt NCBI |
| VPS50 | Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) | 5 | UniProt NCBI |
| VPS53 | Vacuolar protein sorting-associated protein 53 homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6463 | 3.36110250117e-12 | 0.5 | VPS51 VPS53 VPS54 VPS52 | GARP complex |
| CORUM:6459 | 3.36110250117e-12 | 0.5 | VPS51 VPS53 VPS52 VPS50 | EARP complex |
| GO:1990745 | 9.20740386965e-09 | 0.5 | VPS51 VPS53 VPS52 VPS50 | EARP complex |
| GO:0000938 | 9.20740386965e-09 | 0.5 | VPS51 VPS53 VPS54 VPS52 | GARP complex |
| REAC:R-HSA-6811440 | 1.38487166109e-06 | 0.5 | VPS51 VPS53 VPS54 VPS52 | Retrograde transport at the Trans-Golgi-Network |
| REAC:R-HSA-6811442 | 0.000421277670154 | 0.5 | VPS51 VPS53 VPS54 VPS52 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0099023 | 0.000949254500283 | 0.5 | VPS51 VPS53 VPS54 VPS52 | vesicle tethering complex |
| GO:0032456 | 0.00220411413747 | 0.5 | VPS51 VPS53 VPS52 VPS50 | endocytic recycling |
| GO:0016197 | 0.00334675231713 | 0.625 | VPS51 VPS53 VPS50 VPS54 VPS52 | endosomal transport |
| GO:0042147 | 0.00349206859402 | 0.5 | VPS51 VPS53 VPS54 VPS52 | retrograde transport, endosome to Golgi |
| GO:0032588 | 0.00482963771614 | 0.5 | VPS51 VPS53 VPS54 VPS52 | trans-Golgi network membrane |
| GO:0007041 | 0.00894726611169 | 0.5 | VPS51 VPS53 VPS54 VPS52 | lysosomal transport |
| GO:0016482 | 0.0142611443327 | 0.5 | VPS51 VPS53 VPS54 VPS52 | cytosolic transport |
| GO:0098876 | 0.0197287134506 | 0.5 | VPS51 VPS53 VPS52 VPS50 | vesicle-mediated transport to the plasma membrane |
| GO:0007034 | 0.0216379442604 | 0.5 | VPS51 VPS53 VPS54 VPS52 | vacuolar transport |
| GO:0055037 | 0.0243940520291 | 0.5 | VPS51 VPS53 VPS52 VPS50 | recycling endosome |
| REAC:R-HSA-199991 | 0.0307022914608 | 0.5 | VPS51 VPS53 VPS54 VPS52 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0379039189287 | 0.5 | VPS51 VPS53 VPS54 VPS52 | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| VPS51 | VPS53 | 1.0 | 0.638 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM | |
| VPS54 | VPS53 | 0.999 | 0.3 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VPS52 | VPS50 | 0.999 | 0.36 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| VPS51 | VPS50 | 0.999 | 0.538 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo fraction boldt_WMM | |
| VPS50 | VPS53 | 0.999 | 0.502 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM | |
| VPS52 | VPS53 | 0.997 | 0.364 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| VPS54 | VPS50 | 0.997 | 0.14 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| ENOPH1 | VPS52 | 0.993 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VPS54 | GINS2 | 0.993 | 0.096 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VPS52 | VPS51 | 0.992 | 0.538 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| GINS2 | VPS50 | 0.987 | 0.014 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VPS54 | VPS52 | 0.975 | 0.386 | bioplex_WMM bioplex3_WMM WMM_only | |
| VPS52 | GINS2 | 0.972 | 0.038 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GINS2 | VPS53 | 0.942 | 0.04 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VPS54 | VPS51 | 0.937 | 0.214 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| VPS51 | GINS2 | 0.927 | 0.026 |
mutually_exclusive (Q53HC9)
|
bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| VPS54 | TXNDC2 | 0.898 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| VPS53 | TXNDC2 | 0.88 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes