hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13713.1
Complex Portal: CPX-15540
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GJB2 | Gap junction beta-2 protein (Connexin-26) (Cx26) | 5 | UniProt NCBI |
| PRND | Prion-like protein doppel (PrPLP) (Prion protein 2) | 5 | UniProt NCBI |
| GJA3 | Gap junction alpha-3 protein (Connexin-46) (Cx46) | 5 | UniProt NCBI |
| GJB3 | Gap junction beta-3 protein (Connexin-31) (Cx31) | 5 | UniProt NCBI |
| GJB5 | Gap junction beta-5 protein (Connexin-31.1) (Cx31.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-190861 | 4.59102468944e-06 | 0.75 | GJB5 GJA3 GJB3 | Gap junction assembly |
| REAC:R-HSA-190828 | 1.28002609524e-05 | 0.75 | GJB5 GJA3 GJB3 | Gap junction trafficking |
| REAC:R-HSA-157858 | 1.38374083551e-05 | 0.75 | GJB5 GJA3 GJB3 | Gap junction trafficking and regulation |
| GO:0005243 | 6.34131776058e-05 | 0.75 | GJB5 GJA3 GJB3 | gap junction channel activity |
| GO:0005922 | 6.34131776058e-05 | 0.75 | GJB5 GJA3 GJB3 | connexin complex |
| WP:WP536 | 7.92185909125e-05 | 0.75 | GJB5 GJA3 GJB3 | Calcium regulation in cardiac cells |
| GO:0005921 | 0.000109904886398 | 0.75 | GJB5 GJA3 GJB3 | gap junction |
| GO:0022829 | 0.000215165225046 | 0.75 | GJB5 GJA3 GJB3 | wide pore channel activity |
| REAC:R-HSA-199991 | 0.0424877030349 | 0.75 | GJB5 GJA3 GJB3 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0499402458571 | 0.75 | GJB5 GJA3 GJB3 | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GJB3 | GJB5 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GJB3 | PRND | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GJB3 | GJA3 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GJB2 | GJA3 | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GJB3 | GJB2 | 0.269 | bioplex3_WMM WMM_only |
Related Complexes