hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13717.1
Complex Portal: CPX-12778
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MIB2 | E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1) | 5 | UniProt NCBI |
| IKZF3 | Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) | 5 | UniProt NCBI |
| ZNF225 | Zinc finger protein 225 | 3 | UniProt NCBI |
| ZNF518B | Zinc finger protein 518B | 3 | UniProt NCBI |
| IKZF4 | Zinc finger protein Eos (Ikaros family zinc finger protein 4) | 5 | UniProt NCBI |
| IKZF1 | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | 5 | UniProt NCBI |
| IKZF2 | Zinc finger protein Helios (Ikaros family zinc finger protein 2) | 5 | UniProt NCBI |
| IKZF5 | Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000977 | 0.00123422340003 | 0.875 | IKZF4 IKZF3 ZNF225 IKZF1 ZNF518B IKZF5 IKZF2 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO:0003700 | 0.00156294453444 | 0.875 | IKZF4 IKZF3 ZNF225 IKZF1 ZNF518B IKZF5 IKZF2 | DNA-binding transcription factor activity |
| GO:0000976 | 0.0022345160433 | 0.875 | IKZF4 IKZF3 ZNF225 IKZF1 ZNF518B IKZF5 IKZF2 | transcription cis-regulatory region binding |
| GO:0001067 | 0.0022504485569 | 0.875 | IKZF4 IKZF3 ZNF225 IKZF1 ZNF518B IKZF5 IKZF2 | transcription regulatory region nucleic acid binding |
| GO:1990837 | 0.00309645370336 | 0.875 | IKZF4 IKZF3 ZNF225 IKZF1 ZNF518B IKZF5 IKZF2 | sequence-specific double-stranded DNA binding |
| GO:0043565 | 0.00508872640915 | 0.875 | IKZF4 IKZF3 ZNF225 IKZF1 ZNF518B IKZF5 IKZF2 | sequence-specific DNA binding |
| GO:0003690 | 0.00518576601331 | 0.875 | IKZF4 IKZF3 ZNF225 IKZF1 ZNF518B IKZF5 IKZF2 | double-stranded DNA binding |
| GO:0140110 | 0.0199690540385 | 0.875 | IKZF4 IKZF3 ZNF225 IKZF1 ZNF518B IKZF5 IKZF2 | transcription regulator activity |
| GO:0000978 | 0.0256033984124 | 0.75 | IKZF5 IKZF3 ZNF225 IKZF1 IKZF4 IKZF2 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000987 | 0.0289486228107 | 0.75 | IKZF5 IKZF3 ZNF225 IKZF1 IKZF4 IKZF2 | cis-regulatory region sequence-specific DNA binding |
| GO:0003677 | 0.0433468686155 | 0.875 | IKZF4 IKZF3 ZNF225 IKZF1 ZNF518B IKZF5 IKZF2 | DNA binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IKZF3 | IKZF4 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| IKZF2 | IKZF1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| IKZF1 | IKZF4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| IKZF1 | IKZF3 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF1 | ZNF225 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF5 | IKZF2 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF5 | IKZF3 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF5 | IKZF1 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MIB2 | IKZF5 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF5 | IKZF4 | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZNF518B | IKZF5 | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF4 | ZNF225 | 0.948 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| MIB2 | IKZF1 | 0.948 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF2 | IKZF4 | 0.797 | bioplex_WMM bioplex3_WMM WMM_only | ||
| IKZF2 | ZNF225 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF518B | IKZF2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| IKZF2 | IKZF3 | 0.36 | 0.182 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF518B | IKZF3 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF518B | IKZF4 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| IKZF3 | ZNF225 | 0.262 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MIB2 | IKZF2 | 0.211 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MIB2 | IKZF3 | 0.202 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| MIB2 | IKZF4 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only | ||
| IKZF5 | ZNF225 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MIB2 | ZNF518B | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MIB2 | ZNF225 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes