hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13727.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP3B1 | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | 5 | UniProt NCBI |
| AP3M2 | AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B) | 5 | UniProt NCBI |
| AP3M1 | AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) | 5 | UniProt NCBI |
| AP3D1 | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | 5 | UniProt NCBI |
| AP3S2 | AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b) | 5 | UniProt NCBI |
| AP3B2 | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:59 | 6.2981295794e-20 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | AP3 adaptor complex |
| GO:0035652 | 2.58853125713e-17 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | clathrin-coated vesicle cargo loading |
| GO:0035654 | 2.58853125713e-17 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | clathrin-coated vesicle cargo loading, AP-3-mediated |
| CORUM:652 | 4.50316264927e-17 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | AP3-BLOC1 complex |
| GO:0030123 | 3.10623750856e-16 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | AP-3 adaptor complex |
| GO:0048490 | 6.86478489392e-14 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | anterograde synaptic vesicle transport |
| GO:0099514 | 6.86478489392e-14 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | synaptic vesicle cytoskeletal transport |
| GO:0099517 | 6.86478489392e-14 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | synaptic vesicle transport along microtubule |
| GO:0035459 | 2.72269483219e-12 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | vesicle cargo loading |
| GO:0048489 | 3.35100902423e-12 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | synaptic vesicle transport |
| GO:0030119 | 6.00228627904e-12 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | AP-type membrane coat adaptor complex |
| GO:0097479 | 8.59682292869e-12 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | synaptic vesicle localization |
| KEGG:04142 | 1.62669554724e-11 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | Lysosome |
| GO:0047496 | 1.66272012603e-11 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | vesicle transport along microtubule |
| GO:0008089 | 1.93984014703e-11 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | anterograde axonal transport |
| GO:0098930 | 9.55063198366e-11 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | axonal transport |
| GO:0008088 | 1.85131237804e-10 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | axo-dendritic transport |
| GO:0099518 | 2.5125586413e-10 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | vesicle cytoskeletal trafficking |
| GO:0072384 | 5.2960979361e-10 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | organelle transport along microtubule |
| GO:0048475 | 1.8673715483e-09 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | coated membrane |
| GO:0030117 | 1.8673715483e-09 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | membrane coat |
| GO:0016183 | 1.97323122031e-09 | 0.666666666667 | AP3M2 AP3B2 AP3S2 AP3D1 | synaptic vesicle coating |
| GO:0070142 | 1.38095933257e-08 | 0.666666666667 | AP3M2 AP3B2 AP3S2 AP3D1 | synaptic vesicle budding |
| GO:0016185 | 1.38095933257e-08 | 0.666666666667 | AP3M2 AP3B2 AP3S2 AP3D1 | synaptic vesicle budding from presynaptic endocytic zone membrane |
| GO:0010970 | 2.90601077444e-08 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | transport along microtubule |
| GO:0099111 | 5.96587412724e-08 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | microtubule-based transport |
| GO:0051650 | 1.05504774769e-07 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | establishment of vesicle localization |
| GO:0030705 | 1.2613582302e-07 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | cytoskeleton-dependent intracellular transport |
| GO:0051648 | 1.30640673842e-07 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | vesicle localization |
| GO:1903232 | 1.20589885889e-06 | 0.666666666667 | AP3B1 AP3S2 AP3M1 AP3D1 | melanosome assembly |
| GO:0005769 | 1.8815358051e-06 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | early endosome |
| GO:0007018 | 1.92413661578e-06 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | microtubule-based movement |
| GO:0060155 | 2.35782092708e-06 | 0.666666666667 | AP3B1 AP3S2 AP3M1 AP3D1 | platelet dense granule organization |
| GO:0016050 | 2.39621111688e-06 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | vesicle organization |
| GO:0051656 | 1.20442419281e-05 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | establishment of organelle localization |
| WP:WP5408 | 1.36192169576e-05 | 0.5 | AP3M2 AP3B2 AP3D1 | 15q25 copy number variation |
| CORUM:2307 | 1.70876175213e-05 | 0.333333333333 | AP3D1 AP3S2 | AP3D1-AP3S2 complex |
| GO:0006901 | 2.05958456954e-05 | 0.666666666667 | AP3M2 AP3B2 AP3S2 AP3D1 | vesicle coating |
| GO:0048753 | 2.31677849716e-05 | 0.666666666667 | AP3B1 AP3S2 AP3M1 AP3D1 | pigment granule organization |
| GO:0032438 | 2.31677849716e-05 | 0.666666666667 | AP3B1 AP3S2 AP3M1 AP3D1 | melanosome organization |
| GO:0033363 | 2.90256325893e-05 | 0.666666666667 | AP3B1 AP3S2 AP3M1 AP3D1 | secretory granule organization |
| GO:0051640 | 5.29316343329e-05 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | organelle localization |
| GO:0048488 | 5.85430293603e-05 | 0.666666666667 | AP3M2 AP3B2 AP3S2 AP3D1 | synaptic vesicle endocytosis |
| GO:0140238 | 5.85430293603e-05 | 0.666666666667 | AP3M2 AP3B2 AP3S2 AP3D1 | presynaptic endocytosis |
| GO:0036465 | 0.000124138457674 | 0.666666666667 | AP3M2 AP3B2 AP3S2 AP3D1 | synaptic vesicle recycling |
| GO:0033059 | 0.000133860108571 | 0.666666666667 | AP3B1 AP3S2 AP3M1 AP3D1 | cellular pigmentation |
| GO:0006900 | 0.000403034704454 | 0.666666666667 | AP3M2 AP3B2 AP3S2 AP3D1 | vesicle budding from membrane |
| GO:0043473 | 0.000426352174493 | 0.666666666667 | AP3B1 AP3S2 AP3M1 AP3D1 | pigmentation |
| GO:0007017 | 0.000561523629641 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | microtubule-based process |
| GO:0005768 | 0.000638687271276 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | endosome |
| HP:0011125 | 0.00107987178333 | 0.333333333333 | AP3B1 AP3D1 | Abnormality of dermal melanosomes |
| GO:0099504 | 0.00186589865871 | 0.666666666667 | AP3M2 AP3B2 AP3S2 AP3D1 | synaptic vesicle cycle |
| GO:0099003 | 0.00209116001178 | 0.666666666667 | AP3M2 AP3B2 AP3S2 AP3D1 | vesicle-mediated transport in synapse |
| GO:0098796 | 0.00312436057741 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | membrane protein complex |
| GO:0046907 | 0.008082403103 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | intracellular transport |
| GO:0006897 | 0.00846008844101 | 0.833333333333 | AP3M2 AP3S2 AP3M1 AP3B2 AP3D1 | endocytosis |
| GO:0016192 | 0.00887756788753 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | vesicle-mediated transport |
| HP:0001022 | 0.0129324670968 | 0.333333333333 | AP3B1 AP3D1 | Albinism |
| HP:0001107 | 0.0226111656051 | 0.333333333333 | AP3B1 AP3D1 | Ocular albinism |
| GO:0098657 | 0.0324403090069 | 0.833333333333 | AP3M2 AP3S2 AP3M1 AP3B2 AP3D1 | import into cell |
| HP:0007513 | 0.0349615340576 | 0.333333333333 | AP3B1 AP3D1 | Generalized hypopigmentation |
| GO:0051649 | 0.0361725108126 | 1.0 | AP3M2 AP3S2 AP3B1 AP3M1 AP3D1 AP3B2 | establishment of localization in cell |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AP3M1 | AP3B2 | 1.0 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| AP3B1 | AP3M1 | 1.0 | 0.782 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| AP3M1 | AP3D1 | 1.0 | 0.794 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3B1 | AP3M2 | 0.999 | 0.28 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| AP3M2 | AP3M1 | 0.998 | 0.636 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| AP3M2 | AP3D1 | 0.995 | 0.604 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| AP3B1 | AP3D1 | 0.993 | 0.806 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AP3M1 | AP3S2 | 0.991 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| AP3B1 | AP3B2 | 0.991 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AP3M2 | AP3B2 | 0.98 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only |
| AP3M2 | AP3S2 | 0.978 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| AP3D1 | AP3S2 | 0.938 | 0.136 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3D1 | AP3B2 | 0.921 | 0.038 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AP3B1 | AP3S2 | 0.834 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3S2 | AP3B2 | 0.747 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes