hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13736.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TNF | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] | 5 | UniProt NCBI |
| XKRX | XK-related protein 2 (Membrane protein XPLAC) (X Kell blood group-related, X-linked) | 3 | UniProt NCBI |
| ICOS | Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD antigen CD278) | 5 | UniProt NCBI |
| FAM234A | Protein FAM234A (Protein ITFG3) | 4 | UniProt NCBI |
| TAS2R8 | Taste receptor type 2 member 8 (T2R8) (Taste receptor family B member 5) (TRB5) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3863 | 0.00687274586933 | 0.4 | TNF ICOS | T cell antigen receptor TCR pathway during Staphylococcus aureus infection |
| WP:WP5218 | 0.00687274586933 | 0.4 | TNF ICOS | Extrafollicular and follicular B cell activation by SARS CoV 2 |
| WP:WP5098 | 0.015731077008 | 0.4 | TNF ICOS | T cell activation SARS CoV 2 |
| KEGG:04660 | 0.0235498516465 | 0.4 | TNF ICOS | T cell receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| XKRX | FAM234A | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TNF | ICOS | 0.949 | bioplex3_HEK293 bioplex3_WMM bioplex () bioplex_WMM | |
| FAM234A | ICOS | 0.929 | bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FAM234A | TAS2R8 | 0.904 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FAM234A | TNF | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes