hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13737.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GUCY1B1 | Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) | 5 | UniProt NCBI |
| GRIN3B | Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B) | 5 | UniProt NCBI |
| NOX5 | NADPH oxidase 5 (EC 1.6.3.-) | 5 | UniProt NCBI |
| GUCY1A2 | Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) | 5 | UniProt NCBI |
| GUCY1A1 | Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) | 5 | UniProt NCBI |
| MXRA7 | Matrix-remodeling-associated protein 7 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:408 | 1.36501667663e-05 | 0.4 | GUCY1B1 GUCY1A1 | Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3) |
| WP:WP5294 | 0.00100346979189 | 0.4 | GUCY1B1 GUCY1A1 | Sildenafil treatment |
| WP:WP5113 | 0.00190535175424 | 0.4 | GUCY1B1 GUCY1A1 | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway |
| REAC:R-HSA-392154 | 0.00206313859056 | 0.4 | GUCY1B1 GUCY1A1 | Nitric oxide stimulates guanylate cyclase |
| WP:WP4008 | 0.00389862536801 | 0.4 | GUCY1B1 GUCY1A1 | NO cGMP PKG mediated neuroprotection |
| WP:WP4222 | 0.0041146517648 | 0.4 | GUCY1B1 GUCY1A1 | Phosphodiesterases in neuronal function |
| KEGG:04730 | 0.00509527283003 | 0.4 | GUCY1B1 GUCY1A1 | Long-term depression |
| KEGG:04924 | 0.00509527283003 | 0.4 | GUCY1B1 GUCY1A1 | Renin secretion |
| KEGG:04970 | 0.00908648748607 | 0.4 | GUCY1B1 GUCY1A1 | Salivary secretion |
| REAC:R-HSA-445355 | 0.0100756681589 | 0.4 | GUCY1B1 GUCY1A1 | Smooth Muscle Contraction |
| KEGG:04540 | 0.0111896078643 | 0.4 | GUCY1B1 GUCY1A1 | Gap junction |
| KEGG:04713 | 0.0118302702264 | 0.4 | GUCY1B1 GUCY1A1 | Circadian entrainment |
| GO:0038060 | 0.0140440992017 | 0.4 | GUCY1B1 GUCY1A1 | nitric oxide-cGMP-mediated signaling pathway |
| GO:0008074 | 0.0140440992017 | 0.4 | GUCY1B1 GUCY1A1 | guanylate cyclase complex, soluble |
| KEGG:04270 | 0.0204627079102 | 0.4 | GUCY1B1 GUCY1A1 | Vascular smooth muscle contraction |
| KEGG:04611 | 0.0213229262457 | 0.4 | GUCY1B1 GUCY1A1 | Platelet activation |
| KEGG:00230 | 0.0213229262457 | 0.4 | GUCY1B1 GUCY1A1 | Purine metabolism |
| KEGG:04921 | 0.03088329966 | 0.4 | GUCY1B1 GUCY1A1 | Oxytocin signaling pathway |
| KEGG:04022 | 0.0346393491085 | 0.4 | GUCY1B1 GUCY1A1 | cGMP-PKG signaling pathway |
| REAC:R-HSA-418346 | 0.0384836492499 | 0.4 | GUCY1B1 GUCY1A1 | Platelet homeostasis |
| CORUM:407 | 0.0498708842806 | 0.2 | GUCY1B1 | Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GUCY1B1 | MXRA7 | 1.0 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GUCY1A2 | GUCY1B1 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GUCY1A1 | GUCY1B1 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GUCY1B1 | GRIN3B | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MXRA7 | GRIN3B | 0.903 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GUCY1B1 | NOX5 | 0.819 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GUCY1A2 | MXRA7 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| GUCY1A2 | GUCY1A1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| GUCY1A1 | MXRA7 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes