hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13748.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ANKS1B | Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) | 5 | UniProt NCBI |
| RASAL2 | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | 5 | UniProt NCBI |
| AGAP2 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | 5 | UniProt NCBI |
| DAB2IP | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | 5 | UniProt NCBI |
| SMAD1 | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | 5 | UniProt NCBI |
| SYNGAP1 | Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5658442 | 0.000252100073401 | 0.5 | RASAL2 SYNGAP1 DAB2IP | Regulation of RAS by GAPs |
| REAC:R-HSA-5673001 | 0.0108645435635 | 0.5 | RASAL2 SYNGAP1 DAB2IP | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0114840601602 | 0.5 | RASAL2 SYNGAP1 DAB2IP | MAPK1/MAPK3 signaling |
| REAC:R-HSA-5683057 | 0.0172953493615 | 0.5 | RASAL2 SYNGAP1 DAB2IP | MAPK family signaling cascades |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DAB2IP | RASAL2 | 0.998 | bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 WMM_only boldt_WMM | |
| ANKS1B | DAB2IP | 0.989 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SMAD1 | DAB2IP | 0.911 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| AGAP2 | DAB2IP | 0.904 | bioplex3_WMM WMM_only | |
| AGAP2 | RASAL2 | 0.892 | bioplex3_WMM WMM_only | |
| RASAL2 | SYNGAP1 | 0.853 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ANKS1B | RASAL2 | 0.849 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SMAD1 | RASAL2 | 0.102 | bioplex3_WMM WMM_only | |
| DAB2IP | SYNGAP1 | 0.078 | bioplex3_WMM WMM_only | |
| ANKS1B | AGAP2 | 0.013 | fraction |
Related Complexes