hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13758.1
Complex Portal: CPX-24625
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC8A1 | Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) | 5 | UniProt NCBI |
| MARCHF1 | E3 ubiquitin-protein ligase MARCHF1 (EC 2.3.2.27) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) (RING finger protein 171) (RING-type E3 ubiquitin transferase MARCHF1) | 5 | UniProt NCBI |
| KCNK18 | Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) | 5 | UniProt NCBI |
| ACVR1 | Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) | 5 | UniProt NCBI |
| ACVRL1 | Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I) | 5 | UniProt NCBI |
| FZD8 | Frizzled-8 (Fz-8) (hFz8) | 5 | UniProt NCBI |
| LRRIQ1 | Leucine-rich repeat and IQ domain-containing protein 1 | 3 | UniProt NCBI |
| EPHA3 | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | 5 | UniProt NCBI |
| FKBP1B | Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) (h-FKBP-12) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5576891 | 0.00221515749645 | 0.375 | KCNK18 SLC8A1 FKBP1B | Cardiac conduction |
| REAC:R-HSA-397014 | 0.012158802958 | 0.375 | KCNK18 SLC8A1 FKBP1B | Muscle contraction |
| GO:0070724 | 0.0131096201623 | 0.25 | ACVR1 ACVRL1 | BMP receptor complex |
| REAC:R-HSA-5578775 | 0.0452582424141 | 0.25 | SLC8A1 FKBP1B | Ion homeostasis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ACVR1 | FKBP1B | 0.989 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ACVR1 | SLC8A1 | 0.989 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRRIQ1 | EPHA3 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LRRIQ1 | ACVR1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ACVR1 | KCNK18 | 0.981 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ACVR1 | ACVRL1 | 0.93 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MARCHF1 | EPHA3 | 0.841 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| KCNK18 | FZD8 | 0.835 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SLC8A1 | ACVRL1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FKBP1B | ACVRL1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SLC8A1 | FKBP1B | 0.557 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| EPHA3 | ACVR1 | 0.165 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACVR1 | FZD8 | 0.087 | bioplex3_WMM WMM_only |
Related Complexes