hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13765.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
CDH16	Cadherin-16 (Kidney-specific cadherin) (Ksp-cadherin)	5	UniProt NCBI
FANCB	Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95)	5	UniProt NCBI
FANCL	E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) (RING-type E3 ubiquitin transferase FANCL)	5	UniProt NCBI
FANCC	Fanconi anemia group C protein (Protein FACC)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1152	2.45511732198e-08	0.75	FANCB FANCC FANCL	FA complex (Fanconi anemia complex)
CORUM:245	3.92798604902e-08	0.75	FANCB FANCC FANCL	FA core complex (Fanconi anemia core complex)
CORUM:1624	3.92798604902e-08	0.75	FANCB FANCC FANCL	FA core complex (Fanconi anemia core complex)
CORUM:6884	5.8916765743e-08	0.75	FANCB FANCC FANCL	Fanconi anemia FAAP100 complex
CORUM:2739	8.41624867868e-08	0.75	FANCB FANCC FANCL	FA complex (Fanconi anemia complex)
KEGG:03460	6.30976562692e-06	0.75	FANCB FANCC FANCL	Fanconi anemia pathway
HP:0005522	7.04192883742e-06	0.75	FANCB FANCC FANCL	Pyridoxine-responsive sideroblastic anemia
HP:0010469	8.09780209456e-06	0.75	FANCB FANCC FANCL	Absent testis
REAC:R-HSA-6783310	9.16893973468e-06	0.75	FANCB FANCC FANCL	Fanconi Anemia Pathway
HP:0003974	9.25415545838e-06	0.75	FANCB FANCC FANCL	Absent radius
HP:0003953	1.05155453995e-05	0.75	FANCB FANCC FANCL	Absent forearm bone
HP:0009822	1.05155453995e-05	0.75	FANCB FANCC FANCL	Aplasia involving forearm bones
HP:0100867	1.33716561973e-05	0.75	FANCB FANCC FANCL	Duodenal stenosis
HP:0012848	1.33716561973e-05	0.75	FANCB FANCC FANCL	Small intestinal stenosis
HP:0010293	1.33716561973e-05	0.75	FANCB FANCC FANCL	Aplasia/Hypoplasia of the uvula
HP:0100760	1.49754852965e-05	0.75	FANCB FANCC FANCL	Clubbing of toes
HP:0002245	1.49754852965e-05	0.75	FANCB FANCC FANCL	Meckel diverticulum
CORUM:6885	1.53774525569e-05	0.5	FANCB FANCL	L-B-P100 subcomplex
HP:0100587	1.85574544538e-05	0.75	FANCB FANCC FANCL	Abnormal preputium morphology
HP:0001924	2.26688453372e-05	0.75	FANCB FANCC FANCL	Sideroblastic anemia
HP:0001549	3.55023502799e-05	0.75	FANCB FANCC FANCL	Abnormal ileum morphology
HP:0000813	6.4809668811e-05	0.75	FANCB FANCC FANCL	Bicornuate uterus
CORUM:1625	7.68662167609e-05	0.5	FANCB FANCC	FA core complex (Fanconi anemia core complex)
HP:0007874	7.89834426977e-05	0.75	FANCB FANCC FANCL	Almond-shaped palpebral fissure
WP:WP4946	8.13748974369e-05	0.75	FANCB FANCC FANCL	DNA repair pathways full network
HP:0100026	8.41302083589e-05	0.75	FANCB FANCC FANCL	Arteriovenous malformation
GO:0043240	8.45465618902e-05	0.75	FANCB FANCC FANCL	Fanconi anaemia nuclear complex
HP:0003022	9.50842005024e-05	0.75	FANCB FANCC FANCL	Hypoplasia of the ulna
HP:0003220	0.00010090049012	0.75	FANCB FANCC FANCL	Abnormality of chromosome stability
HP:0200005	0.000106949015958	0.75	FANCB FANCC FANCL	Abnormal shape of the palpebral fissure
HP:0009777	0.000106949015958	0.75	FANCB FANCC FANCL	Absent thumb
HP:0006495	0.000119760892232	0.75	FANCB FANCC FANCL	Aplasia/Hypoplasia of the ulna
HP:0007565	0.000133556051791	0.75	FANCB FANCC FANCL	Multiple cafe-au-lait spots
CORUM:248	0.000184428417548	0.5	FANCL FANCC	BRAFT complex
HP:0001199	0.000190105075273	0.75	FANCB FANCC FANCL	Triphalangeal thumb
HP:0000072	0.000208772859528	0.75	FANCB FANCC FANCL	Hydroureter
HP:0009821	0.000249691267079	0.75	FANCB FANCC FANCL	Forearm undergrowth
HP:0006501	0.00026069363061	0.75	FANCB FANCC FANCL	Aplasia/Hypoplasia of the radius
CORUM:244	0.000281714206611	0.5	FANCL FANCC	BRAFT complex
HP:0008572	0.000307929500389	0.75	FANCB FANCC FANCL	External ear malformation
HP:0009380	0.000320567621517	0.75	FANCB FANCC FANCL	Aplasia of the fingers
HP:0002246	0.000360544079166	0.75	FANCB FANCC FANCL	Abnormal duodenum morphology
HP:0009824	0.000360544079166	0.75	FANCB FANCC FANCL	Upper limb undergrowth
HP:0005344	0.000388958517719	0.75	FANCB FANCC FANCL	Abnormal carotid artery morphology
HP:0002575	0.000450181828176	0.75	FANCB FANCC FANCL	Tracheoesophageal fistula
HP:0000027	0.000483062708978	0.75	FANCB FANCC FANCL	Azoospermia
HP:0006503	0.00050008620032	0.75	FANCB FANCC FANCL	Aplasia/hypoplasia involving forearm bones
HP:0012745	0.000758944308151	0.75	FANCB FANCC FANCL	Short palpebral fissure
HP:0002863	0.000878354456144	0.75	FANCB FANCC FANCL	Myelodysplasia
HP:0008669	0.000878354456144	0.75	FANCB FANCC FANCL	Abnormal spermatogenesis
HP:0010161	0.000903644973001	0.75	FANCB FANCC FANCL	Abnormal toe phalanx morphology
HP:0001053	0.000903644973001	0.75	FANCB FANCC FANCL	Hypopigmented skin patches
HP:0000957	0.00103738630957	0.75	FANCB FANCC FANCL	Cafe-au-lait spot
HP:0000453	0.00106562365691	0.75	FANCB FANCC FANCL	Choanal atresia
HP:0008053	0.00106562365691	0.75	FANCB FANCC FANCL	Aplasia/Hypoplasia of the iris
HP:0008055	0.00106562365691	0.75	FANCB FANCC FANCL	Aplasia/Hypoplasia affecting the uvea
HP:0002414	0.00109436780307	0.75	FANCB FANCC FANCL	Spina bifida
HP:0001217	0.00112362321993	0.75	FANCB FANCC FANCL	Clubbing
HP:0000415	0.0013101427137	0.75	FANCB FANCC FANCL	Abnormality of the choanae
HP:0008062	0.00134310215964	0.75	FANCB FANCC FANCL	Aplasia/Hypoplasia affecting the anterior segment of the eye
HP:0000324	0.0013766086176	0.75	FANCB FANCC FANCL	Facial asymmetry
HP:0010301	0.00141066655104	0.75	FANCB FANCC FANCL	Spinal dysraphism
HP:0009601	0.00144528042244	0.75	FANCB FANCC FANCL	Aplasia/Hypoplasia of the thumb
HP:0002023	0.00148045469337	0.75	FANCB FANCC FANCL	Anal atresia
HP:0000010	0.00170351843773	0.75	FANCB FANCC FANCL	Recurrent urinary tract infections
HP:0002251	0.00174274034998	0.75	FANCB FANCC FANCL	Aganglionic megacolon
HP:0004362	0.00174274034998	0.75	FANCB FANCC FANCL	Abnormal enteric ganglion morphology
HP:0031105	0.00174274034998	0.75	FANCB FANCC FANCL	Abnormal uterus morphology
HP:0012331	0.00178255832039	0.75	FANCB FANCC FANCL	Abnormal autonomic nervous system morphology
HP:0025633	0.00178255832039	0.75	FANCB FANCC FANCL	Abnormal ureter morphology
HP:0025028	0.00178255832039	0.75	FANCB FANCC FANCL	Abnormal enteric nervous system morphology
HP:0040071	0.00182297680205	0.75	FANCB FANCC FANCL	Abnormal morphology of ulna
HP:0001882	0.00186400024712	0.75	FANCB FANCC FANCL	Leukopenia
HP:0012041	0.00190563310682	0.75	FANCB FANCC FANCL	Decreased fertility in males
GO:0036297	0.00209449363787	0.75	FANCB FANCC FANCL	interstrand cross-link repair
HP:0002778	0.00250434060906	0.75	FANCB FANCC FANCL	Abnormal tracheal morphology
HP:0009892	0.00260592941411	0.5	FANCB FANCL	Anotia
HP:0001646	0.00260627971198	0.75	FANCB FANCC FANCL	Abnormal aortic valve morphology
HP:0012145	0.00265826780487	0.75	FANCB FANCC FANCL	Abnormality of multiple cell lineages in the bone marrow
HP:0010468	0.00287311393068	0.75	FANCB FANCC FANCL	Aplasia/Hypoplasia of the testes
HP:0001562	0.00309920280847	0.75	FANCB FANCC FANCL	Oligohydramnios
HP:0001636	0.00327631805358	0.75	FANCB FANCC FANCL	Tetralogy of Fallot
HP:0010972	0.00346003629838	0.75	FANCB FANCC FANCL	Anemia of inadequate production
HP:0000340	0.00346003629838	0.75	FANCB FANCC FANCL	Sloping forehead
HP:0003221	0.00350734148159	0.5	FANCL FANCC	Chromosomal breakage induced by crosslinking agents
HP:0000172	0.00352276368958	0.75	FANCB FANCC FANCL	Abnormal uvula morphology
HP:0045058	0.00371547168799	0.75	FANCB FANCC FANCL	Abnormality of the testis size
HP:0001034	0.00384775939798	0.75	FANCB FANCC FANCL	Hypermelanotic macule
HP:0008517	0.00400802433742	0.5	FANCB FANCL	Aplasia/Hypoplasia of the sacrum
HP:0009602	0.00405200286793	0.75	FANCB FANCC FANCL	Abnormality of thumb phalanx
HP:0000268	0.00405200286793	0.75	FANCB FANCC FANCL	Dolichocephaly
HP:0005561	0.00412165152512	0.75	FANCB FANCC FANCL	Abnormal bone marrow cell morphology
HP:0000104	0.00440820132211	0.75	FANCB FANCC FANCL	Renal agenesis
HP:0034915	0.00463159007288	0.75	FANCB FANCC FANCL	Abnormal anus morphology
HP:0002818	0.00463159007288	0.75	FANCB FANCC FANCL	Abnormal morphology of the radius
HP:0001010	0.0047076910508	0.75	FANCB FANCC FANCL	Hypopigmentation of the skin
HP:0006101	0.00478461840196	0.75	FANCB FANCC FANCL	Finger syndactyly
HP:0000483	0.00534661814787	0.75	FANCB FANCC FANCL	Astigmatism
GO:0006513	0.00544401218013	0.75	FANCB FANCC FANCL	protein monoubiquitination
HP:0000025	0.00551487774639	0.75	FANCB FANCC FANCL	Functional abnormality of male internal genitalia
HP:0040072	0.00577380592851	0.75	FANCB FANCC FANCL	Abnormal forearm bone morphology
HP:0002973	0.0058618765749	0.75	FANCB FANCC FANCL	Abnormal forearm morphology
HP:0004378	0.00595083516828	0.75	FANCB FANCC FANCL	Abnormality of the anus
HP:0007400	0.00595083516828	0.75	FANCB FANCC FANCL	Irregular hyperpigmentation
HP:0002031	0.0062230825364	0.75	FANCB FANCC FANCL	Abnormal esophagus morphology
HP:0012733	0.0062230825364	0.75	FANCB FANCC FANCL	Macule
REAC:R-HSA-73894	0.00653220236003	0.75	FANCB FANCC FANCL	DNA Repair
HP:0001770	0.00719009671515	0.75	FANCB FANCC FANCL	Toe syndactyly
HP:0000130	0.00760323845564	0.75	FANCB FANCC FANCL	Abnormality of the uterus
HP:0100542	0.00770893005831	0.75	FANCB FANCC FANCL	Abnormal localization of kidney
HP:0009826	0.00770893005831	0.75	FANCB FANCC FANCL	Limb undergrowth
HP:0001710	0.00803184965878	0.75	FANCB FANCC FANCL	Conotruncal defect
HP:0002827	0.00803184965878	0.75	FANCB FANCC FANCL	Hip dislocation
HP:0003026	0.00870438382548	0.75	FANCB FANCC FANCL	Short long bone
HP:0002244	0.00870438382548	0.75	FANCB FANCC FANCL	Abnormal small intestine morphology
HP:0000520	0.00881998427789	0.75	FANCB FANCC FANCL	Proptosis
HP:0100736	0.00929257878792	0.75	FANCB FANCC FANCL	Abnormal soft palate morphology
HP:0011563	0.0096578491403	0.75	FANCB FANCC FANCL	Abnormal ventriculoarterial connection
HP:0006824	0.00978169098064	0.75	FANCB FANCC FANCL	Cranial nerve paralysis
HP:0031910	0.0100325283905	0.75	FANCB FANCC FANCL	Abnormal cranial nerve physiology
HP:0011545	0.0100325283905	0.75	FANCB FANCC FANCL	Abnormal connection of the cardiac segments
HP:0000144	0.0104167341589	0.75	FANCB FANCC FANCL	Decreased fertility
HP:0012874	0.0108105839895	0.75	FANCB FANCC FANCL	Abnormal male reproductive system physiology
HP:0000568	0.0110785663677	0.75	FANCB FANCC FANCL	Microphthalmia
HP:0002032	0.0117117011059	0.5	FANCB FANCL	Esophageal atresia
HP:0001639	0.0120511721551	0.75	FANCB FANCC FANCL	Hypertrophic cardiomyopathy
HP:0002270	0.0121945759809	0.75	FANCB FANCC FANCL	Abnormality of the autonomic nervous system
HP:0002823	0.0124847721541	0.75	FANCB FANCC FANCL	Abnormal femur morphology
HP:0200007	0.0127795152806	0.75	FANCB FANCC FANCL	Abnormal size of the palpebral fissures
HP:0045005	0.0132302314017	0.75	FANCB FANCC FANCL	Neural tube defect
HP:0410043	0.0132302314017	0.75	FANCB FANCC FANCL	Abnormal neural tube morphology
HP:0004377	0.0135364936749	0.75	FANCB FANCC FANCL	Hematological neoplasm
HP:0002143	0.0135364936749	0.75	FANCB FANCC FANCL	Abnormal spinal cord morphology
HP:0001537	0.0136913732677	0.75	FANCB FANCC FANCL	Umbilical hernia
HP:0000953	0.014163057839	0.75	FANCB FANCC FANCL	Hyperpigmentation of the skin
HP:0001551	0.0144834290023	0.75	FANCB FANCC FANCL	Abnormal umbilicus morphology
HP:0030311	0.0153053110125	0.75	FANCB FANCC FANCL	Lower extremity joint dislocation
HP:0100887	0.0153053110125	0.75	FANCB FANCC FANCL	Abnormality of globe size
HP:0000582	0.0172211022813	0.75	FANCB FANCC FANCL	Upslanted palpebral fissure
HP:0007700	0.0172211022813	0.75	FANCB FANCC FANCL	Ocular anterior segment dysgenesis
HP:0100691	0.0179553160304	0.75	FANCB FANCC FANCL	Abnormality of the curvature of the cornea
WP:WP5316	0.0208408229239	0.5	FANCL FANCC	Primary ovarian insufficiency
HP:0006265	0.0213074219839	0.75	FANCB FANCC FANCL	Aplasia/Hypoplasia of fingers
HP:0001654	0.0215165706943	0.75	FANCB FANCC FANCL	Abnormal heart valve morphology
HP:0001763	0.0217270761582	0.75	FANCB FANCC FANCL	Pes planus
HP:0005607	0.0221521745039	0.75	FANCB FANCC FANCL	Abnormal tracheobronchial morphology
HP:0040012	0.0222019103471	0.5	FANCL FANCC	Chromosome breakage
HP:0008678	0.0239076954829	0.75	FANCB FANCC FANCL	Renal hypoplasia/aplasia
HP:0000047	0.0243605289659	0.75	FANCB FANCC FANCL	Hypospadias
HP:0001824	0.0250503832174	0.75	FANCB FANCC FANCL	Weight loss
HP:0001384	0.0255174052948	0.75	FANCB FANCC FANCL	Abnormal hip joint morphology
HP:0000864	0.0269530199508	0.75	FANCB FANCC FANCL	Abnormality of the hypothalamus-pituitary axis
HP:0000069	0.0274431881859	0.75	FANCB FANCC FANCL	Abnormality of the ureter
HP:0001643	0.0274431881859	0.75	FANCB FANCC FANCL	Patent ductus arteriosus
HP:0100627	0.0289490607956	0.75	FANCB FANCC FANCL	Displacement of the urethral meatus
HP:0001373	0.0289490607956	0.75	FANCB FANCC FANCL	Joint dislocation
HP:0032076	0.0292052421452	0.75	FANCB FANCC FANCL	Abnormal male urethral meatus morphology
HP:0001679	0.0292052421452	0.75	FANCB FANCC FANCL	Abnormal aortic morphology
HP:0000238	0.0318501377451	0.75	FANCB FANCC FANCL	Hydrocephalus
HP:0001873	0.0318501377451	0.75	FANCB FANCC FANCL	Thrombocytopenia
HP:0000083	0.0321230291111	0.75	FANCB FANCC FANCL	Renal insufficiency
HP:0004209	0.0329509878386	0.75	FANCB FANCC FANCL	Clinodactyly of the 5th finger
HP:0001172	0.0332300831153	0.75	FANCB FANCC FANCL	Abnormal thumb morphology
HP:0009179	0.0332300831153	0.75	FANCB FANCC FANCL	Deviation of the 5th finger
HP:0000135	0.0335107399856	0.75	FANCB FANCC FANCL	Hypogonadism
HP:0002007	0.0337929626939	0.75	FANCB FANCC FANCL	Frontal bossing
HP:0001159	0.0340767554838	0.75	FANCB FANCC FANCL	Syndactyly
HP:0011218	0.0346490682778	0.75	FANCB FANCC FANCL	Abnormal shape of the frontal region
HP:0430000	0.0349375967643	0.75	FANCB FANCC FANCL	Abnormal frontal bone morphology
HP:0000815	0.0375654511359	0.5	FANCB FANCC	Hypergonadotropic hypogonadism
HP:0011873	0.0397727710244	0.75	FANCB FANCC FANCL	Abnormal platelet count
HP:0011875	0.0407260045359	0.75	FANCB FANCC FANCL	Abnormal platelet morphology
HP:0040019	0.0410470782574	0.75	FANCB FANCC FANCL	Finger clinodactyly
HP:0410008	0.0416942448541	0.75	FANCB FANCC FANCL	Abnormality of the peripheral nervous system
HP:0040070	0.0426776059203	0.75	FANCB FANCC FANCL	Abnormal upper limb bone morphology
HP:0000525	0.0443504519214	0.75	FANCB FANCC FANCL	Abnormality iris morphology
HP:0001560	0.046066142944	0.75	FANCB FANCC FANCL	Abnormality of the amniotic fluid
HP:0000008	0.0467645338244	0.75	FANCB FANCC FANCL	Abnormal morphology of female internal genitalia
HP:0000795	0.0471163420483	0.75	FANCB FANCC FANCL	Abnormality of the urethra
HP:0001872	0.0478252050842	0.75	FANCB FANCC FANCL	Abnormality of thrombocytes
HP:0008056	0.0499940694024	0.75	FANCB FANCC FANCL	Aplasia/Hypoplasia affecting the eye

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
FANCL	FANCC	0.994		bioplex3_WMM bioplex3_HCT116 WMM_only
FANCB	FANCC	0.993		bioplex3_WMM bioplex3_HCT116 WMM_only
FANCL	FANCB	0.991	0.226	hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM
CDH16	FANCL	0.975		bioplex3_HEK293 bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
CDH16	huMAP3_00342.1 huMAP3_05216.1 huMAP3_05580.1 huMAP3_07690.1 huMAP3_09841.1 huMAP3_10668.1 huMAP3_11458.1 huMAP3_11598.1 huMAP3_13616.1 huMAP3_13765.1 huMAP3_14301.1
FANCB	huMAP3_05216.1 huMAP3_05580.1 huMAP3_07422.1 huMAP3_09841.1 huMAP3_10668.1 huMAP3_11458.1 huMAP3_13616.1 huMAP3_13765.1 huMAP3_15070.1 huMAP3_15301.1
FANCL	huMAP3_00342.1 huMAP3_05216.1 huMAP3_05580.1 huMAP3_07422.1 huMAP3_07690.1 huMAP3_09841.1 huMAP3_10668.1 huMAP3_11458.1 huMAP3_13616.1 huMAP3_13765.1 huMAP3_14301.1 huMAP3_15070.1 huMAP3_15301.1
FANCC	huMAP3_07422.1 huMAP3_09841.1 huMAP3_10668.1 huMAP3_11139.1 huMAP3_11458.1 huMAP3_13616.1 huMAP3_13765.1 huMAP3_15070.1 huMAP3_15301.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13765.1