hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13776.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | 5 | UniProt NCBI |
| PDCD4 | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | 5 | UniProt NCBI |
| EIF4A2 | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4566 | 8.26322288609e-07 | 1.0 | PDCD4 EIF4A1 EIF4A2 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP107 | 0.00132925024934 | 0.666666666667 | EIF4A1 EIF4A2 | Translation factors |
| WP:WP585 | 0.00144101964081 | 0.666666666667 | PDCD4 EIF4A1 | Interferon type I signaling pathways |
| REAC:R-HSA-429947 | 0.00188000535098 | 0.666666666667 | EIF4A1 EIF4A2 | Deadenylation of mRNA |
| REAC:R-HSA-429914 | 0.0101009261622 | 0.666666666667 | EIF4A1 EIF4A2 | Deadenylation-dependent mRNA decay |
| REAC:R-HSA-72702 | 0.0116360425406 | 0.666666666667 | EIF4A1 EIF4A2 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.0116360425406 | 0.666666666667 | EIF4A1 EIF4A2 | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.0120367347963 | 0.666666666667 | EIF4A1 EIF4A2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| REAC:R-HSA-1169408 | 0.0145828870271 | 0.666666666667 | EIF4A1 EIF4A2 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 0.017372320015 | 0.666666666667 | EIF4A1 EIF4A2 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-1280215 | 0.01747853546 | 1.0 | PDCD4 EIF4A1 EIF4A2 | Cytokine Signaling in Immune system |
| REAC:R-HSA-156827 | 0.0406752460979 | 0.666666666667 | EIF4A1 EIF4A2 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.041419681818 | 0.666666666667 | EIF4A1 EIF4A2 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-72737 | 0.0468187221283 | 0.666666666667 | EIF4A1 EIF4A2 | Cap-dependent Translation Initiation |
| REAC:R-HSA-72613 | 0.0468187221283 | 0.666666666667 | EIF4A1 EIF4A2 | Eukaryotic Translation Initiation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF4A1 | EIF4A2 | 0.997 | 0.392 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction treiber_WMM |
| EIF4A1 | PDCD4 | 0.871 | 0.122 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction |
| EIF4A2 | PDCD4 | 0.508 | 0.11 | youn () bioplex_WMM bioplex3_WMM youn_WMM fraction |
Related Complexes