hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13781.1
Complex Portal: CPX-16434
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LRRC8D | Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) | 5 | UniProt NCBI |
| LRRC8C | Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) | 5 | UniProt NCBI |
| LRRC8B | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | 5 | UniProt NCBI |
| NPEPPS | Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6567 | 7.01534115619e-09 | 0.75 | LRRC8C LRRC8D LRRC8B | SWELL1-containing complex |
| REAC:R-HSA-5223345 | 1.59826617962e-06 | 0.75 | LRRC8C LRRC8D LRRC8B | Miscellaneous transport and binding events |
| GO:0005225 | 3.22863876272e-05 | 0.75 | LRRC8C LRRC8D LRRC8B | volume-sensitive anion channel activity |
| WP:WP5083 | 7.71006438268e-05 | 0.75 | LRRC8C LRRC8D LRRC8B | Neuroinflammation and glutamatergic signaling |
| GO:0098656 | 0.00544401218013 | 0.75 | LRRC8C LRRC8D LRRC8B | monoatomic anion transmembrane transport |
| GO:0005253 | 0.0106287970558 | 0.75 | LRRC8C LRRC8D LRRC8B | monoatomic anion channel activity |
| GO:0006820 | 0.0248327141789 | 0.75 | LRRC8C LRRC8D LRRC8B | monoatomic anion transport |
| GO:0008509 | 0.0326725154884 | 0.75 | LRRC8C LRRC8D LRRC8B | monoatomic anion transmembrane transporter activity |
| REAC:R-HSA-382551 | 0.0342552713859 | 0.75 | LRRC8C LRRC8D LRRC8B | Transport of small molecules |
| CORUM:6581 | 0.049938562206 | 0.25 | LRRC8C | LRRC8A-LRRC8C complex |
| CORUM:6582 | 0.049938562206 | 0.25 | LRRC8D | LRRC8A-LRRC8D complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LRRC8C | LRRC8B | 0.995 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRRC8D | LRRC8B | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NPEPPS | LRRC8B | 0.983 |
structurally_consistent (Q8TDW0)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NPEPPS | LRRC8D | 0.946 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NPEPPS | LRRC8C | 0.855 | 0.03 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| LRRC8D | LRRC8C | 0.396 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes