hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13784.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAD18 | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | 5 | UniProt NCBI |
| UBE2B | Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B) | 5 | UniProt NCBI |
| UBE2A | Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8866654 | 1.1573599509e-05 | 1.0 | UBE2A RAD18 UBE2B | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-8852135 | 3.02470171978e-05 | 1.0 | UBE2A RAD18 UBE2B | Protein ubiquitination |
| GO:0006301 | 0.000476755403739 | 1.0 | UBE2A RAD18 UBE2B | postreplication repair |
| REAC:R-HSA-110314 | 0.00296224002415 | 0.666666666667 | RAD18 UBE2B | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-8866652 | 0.00296224002415 | 0.666666666667 | UBE2A UBE2B | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| KEGG:04120 | 0.00686279305854 | 0.666666666667 | UBE2A UBE2B | Ubiquitin mediated proteolysis |
| REAC:R-HSA-73893 | 0.00735562020533 | 0.666666666667 | RAD18 UBE2B | DNA Damage Bypass |
| GO:0033503 | 0.00842684400117 | 0.666666666667 | UBE2A UBE2B | HULC complex |
| GO:0031371 | 0.0393180950424 | 0.666666666667 | UBE2A UBE2B | ubiquitin conjugating enzyme complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAD18 | UBE2A | 0.999 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| UBE2B | UBE2A | 0.97 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RAD18 | UBE2B | 0.965 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes