hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13786.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP3B1 | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | 5 | UniProt NCBI |
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
| GRM3 | Metabotropic glutamate receptor 3 (mGluR3) | 5 | UniProt NCBI |
| PPRC1 | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | 5 | UniProt NCBI |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | 5 | UniProt NCBI |
| NOS1AP | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | 5 | UniProt NCBI |
| CHD9 | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | 5 | UniProt NCBI |
| C1orf226 | Uncharacterized protein C1orf226 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 1.53016055105e-07 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Synthesis of PIPs in the nucleus |
| REAC:R-HSA-6811555 | 3.20839170288e-06 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | PI5P Regulates TP53 Acetylation |
| GO:0016309 | 8.07408345042e-06 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902633 | 8.07408345042e-06 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:1902635 | 8.07408345042e-06 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| REAC:R-HSA-6804758 | 0.000154071905864 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Regulation of TP53 Activity through Acetylation |
| WP:WP5411 | 0.000167122221162 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Phosphatidyl inositol phosphate pathway |
| WP:WP4971 | 0.000167122221162 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Phosphoinositides metabolism |
| KEGG:00562 | 0.000349846288075 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Inositol phosphate metabolism |
| GO:0016308 | 0.00045145282213 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| REAC:R-HSA-1660499 | 0.00061212143341 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Synthesis of PIPs at the plasma membrane |
| KEGG:04070 | 0.000786208588489 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Phosphatidylinositol signaling system |
| REAC:R-HSA-1483255 | 0.00223412593886 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | PI Metabolism |
| REAC:R-HSA-6811558 | 0.00242682057997 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.00318723393935 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Negative regulation of the PI3K/AKT network |
| WP:WP51 | 0.00483937363749 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Regulation of actin cytoskeleton |
| GO:2000786 | 0.00546674693619 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | positive regulation of autophagosome assembly |
| KEGG:04810 | 0.00936207220365 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Regulation of actin cytoskeleton |
| GO:0044090 | 0.0123615112794 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | positive regulation of vacuole organization |
| GO:0052742 | 0.0142113571615 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | phosphatidylinositol kinase activity |
| GO:0046627 | 0.0184449339515 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | negative regulation of insulin receptor signaling pathway |
| GO:1900077 | 0.020844368733 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | negative regulation of cellular response to insulin stimulus |
| REAC:R-HSA-5633007 | 0.0209695640384 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Regulation of TP53 Activity |
| REAC:R-HSA-1483257 | 0.0324003372669 | 0.333333333333 | PIP4K2A PIP4K2B PIP4K2C | Phospholipid metabolism |
| CORUM:6371 | 0.0499842271994 | 0.111111111111 | GRM3 | mGluR3-mGluR8 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 1.0 | 0.014 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PIP4K2A | PIP4K2C | 1.0 | 0.0883043478261 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PIP4K2A | PIP4K2B | 1.0 | 0.318 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| PIP4K2A | NOS1AP | 0.997 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PIP4K2A | GRM3 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PIP4K2C | NOS1AP | 0.982 | 0.098 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| NOS1AP | C1orf226 | 0.973 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CHD9 | PIP4K2A | 0.972 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PIP4K2B | NOS1AP | 0.971 | 0.042 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PIP4K2A | PPRC1 | 0.969 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PIP4K2A | C1orf226 | 0.952 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PIP4K2C | AP3B1 | 0.922 | 0.158 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| PIP4K2A | AP3B1 | 0.816 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| CHD9 | NOS1AP | 0.541 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only |
| PPRC1 | GRM3 | 0.53 | bioplex_WMM bioplex3_WMM WMM_only | |
| CHD9 | PPRC1 | 0.433 | 0.114 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2B | GRM3 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | |
| GRM3 | C1orf226 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | |
| CHD9 | GRM3 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | |
| CHD9 | AP3B1 | 0.246 | 0.102 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PPRC1 | AP3B1 | 0.237 | 0.158 | bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2B | PPRC1 | 0.213 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only |
| CHD9 | C1orf226 | 0.198 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2C | C1orf226 | 0.188 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only |
| PPRC1 | PIP4K2C | 0.187 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
| GRM3 | AP3B1 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | |
| PPRC1 | C1orf226 | 0.164 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only |
| CHD9 | PIP4K2C | 0.162 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PPRC1 | NOS1AP | 0.145 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2C | GRM3 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | |
| AP3B1 | NOS1AP | 0.142 | 0.088 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PIP4K2B | C1orf226 | 0.131 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only |
| AP3B1 | C1orf226 | 0.127 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only |
| CHD9 | PIP4K2B | 0.127 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only |
| GRM3 | NOS1AP | 0.123 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIP4K2B | AP3B1 | 0.024 | 0.044 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes