hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13790.1
Complex Portal: CPX-15031
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CKLF | Chemokine-like factor (C32) | 5 | UniProt NCBI |
| LZTR1 | Leucine-zipper-like transcriptional regulator 1 (LZTR-1) | 5 | UniProt NCBI |
| GLIPR1 | Glioma pathogenesis-related protein 1 (GliPR 1) (Protein RTVP-1) | 4 | UniProt NCBI |
| RIT1 | GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1) | 5 | UniProt NCBI |
| SH3BGRL2 | SH3 domain-binding glutamic acid-rich-like protein 2 (Fovea-associated SH3 domain-binding protein) | 3 | UniProt NCBI |
| RIT2 | GTP-binding protein Rit2 (EC 3.6.5.2) (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-187706 | 7.74455426548e-05 | 0.333333333333 | RIT1 RIT2 | Signalling to p38 via RIT and RIN |
| HP:0007517 | 0.0022669030801 | 0.333333333333 | LZTR1 RIT1 | Palmoplantar cutis laxa |
| HP:0007605 | 0.00485499013014 | 0.333333333333 | LZTR1 RIT1 | Excessive wrinkling of palmar skin |
| REAC:R-HSA-187687 | 0.00835477835936 | 0.333333333333 | RIT1 RIT2 | Signalling to ERKs |
| HP:0011381 | 0.011317974846 | 0.333333333333 | LZTR1 RIT1 | Aplasia of the semicircular canal |
| HP:0011380 | 0.0164828756284 | 0.333333333333 | LZTR1 RIT1 | Abnormal semicircular canal morphology |
| HP:0012209 | 0.0164828756284 | 0.333333333333 | LZTR1 RIT1 | Juvenile myelomonocytic leukemia |
| HP:0012569 | 0.0226111656051 | 0.333333333333 | LZTR1 RIT1 | Delayed menarche |
| HP:0011376 | 0.0349615340576 | 0.333333333333 | LZTR1 RIT1 | Abnormal morphology of the vestibule of the inner ear |
| HP:0012324 | 0.037751561683 | 0.333333333333 | LZTR1 RIT1 | Myeloid leukemia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GLIPR1 | RIT1 | 0.997 | 0.11 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RIT1 | RIT2 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LZTR1 | RIT1 | 0.985 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CKLF | GLIPR1 | 0.98 | 0.154 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CKLF | RIT1 | 0.902 | 0.104 | bioplex3_WMM WMM_only | |
| GLIPR1 | SH3BGRL2 | 0.805 | 0.078 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LZTR1 | RIT2 | 0.403 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CKLF | SH3BGRL2 | 0.126 | 0.054 | bioplex3_WMM WMM_only | |
| RIT1 | SH3BGRL2 | 0.101 | 0.122 | bioplex3_WMM WMM_only | |
| LZTR1 | SH3BGRL2 | 0.008 | 0.042 | bioplex3_WMM WMM_only |
Related Complexes