hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13816.1
Complex Portal: CPX-24423
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NFIC | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | 5 | UniProt NCBI |
| WRN | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | 5 | UniProt NCBI |
| NFIB | Nuclear factor 1 B-type (NF1-B) (Nuclear factor 1/B) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/B) (NF-I/B) (NFI-B) (TGGCA-binding protein) | 5 | UniProt NCBI |
| NFIX | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | 5 | UniProt NCBI |
| NFIA | Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-73980 | 3.77850578875e-09 | 0.8 | NFIC NFIA NFIB NFIX | RNA Polymerase III Transcription Termination |
| REAC:R-HSA-749476 | 3.50664405889e-08 | 0.8 | NFIC NFIA NFIB NFIX | RNA Polymerase III Abortive And Retractive Initiation |
| REAC:R-HSA-74158 | 3.50664405889e-08 | 0.8 | NFIC NFIA NFIB NFIX | RNA Polymerase III Transcription |
| HPA:0461443 | 0.000195356966163 | 0.8 | NFIC NFIA NFIB NFIX | skin 1; fibrohistiocytic cells[High] |
| REAC:R-HSA-74160 | 0.000887298860527 | 1.0 | NFIC NFIX NFIA NFIB WRN | Gene expression (Transcription) |
| HPA:0461392 | 0.00123701046093 | 0.8 | NFIC NFIA NFIB NFIX | skin 1; cells in basal layer[>=Medium] |
| HPA:0151342 | 0.00148927227463 | 0.6 | NFIC NFIB NFIA | duodenum; glands of Brunner[>=Medium] |
| HPA:0471412 | 0.00154572452116 | 0.8 | NFIC NFIA NFIB NFIX | skin 2; cells in spinous layer[>=Medium] |
| HPA:0461393 | 0.00167292187702 | 0.6 | NFIC NFIB NFIX | skin 1; cells in basal layer[High] |
| HPA:0461442 | 0.00170451251374 | 0.8 | NFIC NFIA NFIB NFIX | skin 1; fibrohistiocytic cells[>=Medium] |
| HPA:0030432 | 0.00202156604028 | 0.6 | NFIC NFIB NFIA | appendix; germinal center cells[>=Medium] |
| HPA:0471392 | 0.00235731622727 | 0.8 | NFIC NFIA NFIB NFIX | skin 2; cells in basal layer[>=Medium] |
| HPA:0461411 | 0.00251845971887 | 0.8 | NFIC NFIA NFIB NFIX | skin 1; cells in spinous layer[>=Low] |
| HPA:0030442 | 0.00326258955925 | 0.6 | NFIC NFIB NFIA | appendix; non-germinal center cells[>=Medium] |
| HPA:0151341 | 0.00334812702156 | 0.6 | NFIC NFIB NFIA | duodenum; glands of Brunner[>=Low] |
| HPA:0471442 | 0.00338130785257 | 0.8 | NFIC NFIA NFIB NFIX | skin 2; fibrohistiocytic cells[>=Medium] |
| HPA:0030431 | 0.00408635732306 | 0.6 | NFIC NFIB NFIA | appendix; germinal center cells[>=Low] |
| HPA:0471411 | 0.00412014949722 | 0.8 | NFIC NFIA NFIB NFIX | skin 2; cells in spinous layer[>=Low] |
| HPA:0461441 | 0.00434283939871 | 0.8 | NFIC NFIA NFIB NFIX | skin 1; fibrohistiocytic cells[>=Low] |
| HPA:0461391 | 0.00442599517947 | 0.8 | NFIC NFIA NFIB NFIX | skin 1; cells in basal layer[>=Low] |
| HP:0012741 | 0.00499516489297 | 0.4 | NFIX NFIB | Unilateral cryptorchidism |
| HPA:0471393 | 0.00605918446772 | 0.6 | NFIC NFIB NFIX | skin 2; cells in basal layer[High] |
| HPA:0471391 | 0.00616172683602 | 0.8 | NFIC NFIA NFIB NFIX | skin 2; cells in basal layer[>=Low] |
| HPA:0030441 | 0.00658414755959 | 0.6 | NFIC NFIB NFIA | appendix; non-germinal center cells[>=Low] |
| HPA:0471441 | 0.00754988101369 | 0.8 | NFIC NFIA NFIB NFIX | skin 2; fibrohistiocytic cells[>=Low] |
| HPA:0131332 | 0.00757344831865 | 0.6 | NFIC NFIB NFIA | colon; mucosal lymphoid cells[>=Medium] |
| HPA:0401332 | 0.0100127876744 | 0.6 | NFIC NFIB NFIA | rectum; mucosal lymphoid cells[>=Medium] |
| HPA:0400891 | 0.010555544314 | 0.6 | NFIC NFIB NFIA | rectum; goblet cells[>=Low] |
| HPA:0400653 | 0.0142735424602 | 0.4 | NFIB NFIA | rectum; fibroblasts[High] |
| HPA:0031301 | 0.0172071774588 | 0.6 | NFIC NFIB NFIA | appendix; enterocytes[>=Low] |
| HPA:0131331 | 0.0191811519078 | 0.6 | NFIC NFIB NFIA | colon; mucosal lymphoid cells[>=Low] |
| HPA:0401301 | 0.0214446064427 | 0.6 | NFIC NFIB NFIA | rectum; enterocytes[>=Low] |
| HPA:0471443 | 0.0223365489821 | 0.6 | NFIC NFIA NFIX | skin 2; fibrohistiocytic cells[High] |
| HPA:0401331 | 0.0241927281198 | 0.6 | NFIC NFIB NFIA | rectum; mucosal lymphoid cells[>=Low] |
| HP:0010938 | 0.026951343784 | 0.8 | WRN NFIA NFIB NFIX | Abnormal external nose morphology |
| HPA:0420053 | 0.029577214981 | 0.8 | NFIC NFIA NFIB NFIX | salivary gland; glandular cells[High] |
| HPA:0400203 | 0.031453796633 | 0.4 | NFIB NFIA | rectum; endothelial cells[High] |
| HP:0100729 | 0.0342232629352 | 0.6 | NFIX NFIB NFIA | Large face |
| HPA:0151343 | 0.0350843208472 | 0.4 | NFIC NFIA | duodenum; glands of Brunner[High] |
| HPA:0400652 | 0.0412996825225 | 0.4 | NFIB NFIA | rectum; fibroblasts[>=Medium] |
| HPA:0170251 | 0.0422298811316 | 1.0 | NFIC NFIX NFIA NFIB WRN | endometrium 2; cells in endometrial stroma[>=Low] |
| HPA:0380512 | 0.0457288865022 | 1.0 | NFIC NFIX NFIA NFIB WRN | placenta; decidual cells[>=Medium] |
| HPA:0460202 | 0.0460879152407 | 0.6 | NFIC NFIB NFIA | skin 1; endothelial cells[>=Medium] |
| HPA:0461412 | 0.0463303695681 | 0.6 | NFIC NFIB NFIA | skin 1; cells in spinous layer[>=Medium] |
| CORUM:4082 | 0.0498708842806 | 0.2 | WRN | XRCC6-XRCC5-WRN complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NFIC | NFIB | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | ||
| NFIB | NFIX | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NFIB | NFIA | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | ||
| WRN | NFIB | 0.88 | hein_WMM youn_WMM WMM_only | ||
| NFIC | NFIX | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NFIX | NFIA | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NFIC | NFIA | 0.509 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| WRN | NFIA | 0.044 | youn_WMM WMM_only | ||
| WRN | NFIC | 0.014 | 0.042 | youn_WMM WMM_only |
Related Complexes