hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13822.1
Complex Portal: CPX-25321
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS11 | Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) | 5 | UniProt NCBI |
| VPS18 | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | 5 | UniProt NCBI |
| VPS16 | Vacuolar protein sorting-associated protein 16 homolog (hVPS16) | 5 | UniProt NCBI |
| TECPR2 | Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) | 5 | UniProt NCBI |
| TGFBRAP1 | Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1) | 5 | UniProt NCBI |
| DNAJB5 | DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-2) (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40) | 4 | UniProt NCBI |
| VPS41 | Vacuolar protein sorting-associated protein 41 homolog (S53) | 5 | UniProt NCBI |
| VPS33A | Vacuolar protein sorting-associated protein 33A (hVPS33A) | 5 | UniProt NCBI |
| VPS39 | Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6389 | 9.2015673155e-16 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | HOPS complex |
| GO:0034058 | 4.78079945042e-14 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | endosomal vesicle fusion |
| GO:0035542 | 9.56047657747e-14 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | regulation of SNARE complex assembly |
| REAC:R-HSA-9754560 | 2.70176605656e-13 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | SARS-CoV-2 modulates autophagy |
| GO:0035493 | 1.91943403175e-12 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | SNARE complex assembly |
| CORUM:6388 | 1.68018318789e-11 | 0.5 | VPS33A TGFBRAP1 VPS18 VPS16 | CORVET complex |
| GO:0030897 | 3.98884551806e-10 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | HOPS complex |
| KEGG:04148 | 4.51466532293e-10 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | Efferocytosis |
| GO:0008333 | 3.34212683662e-09 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | endosome to lysosome transport |
| GO:0099023 | 5.71212163124e-09 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | vesicle tethering complex |
| GO:0033263 | 2.76161616937e-08 | 0.5 | VPS33A TGFBRAP1 VPS18 VPS16 | CORVET complex |
| GO:0006906 | 6.38324365476e-08 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | vesicle fusion |
| GO:0090174 | 7.30888010199e-08 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | organelle membrane fusion |
| CORUM:2573 | 9.81744484776e-08 | 0.375 | VPS39 VPS18 VPS16 | Class C VPS/HOPS complex |
| WP:WP4217 | 1.44798342499e-07 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | Ebola virus infection in host |
| GO:0007041 | 1.74564982193e-07 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | lysosomal transport |
| KEGG:04140 | 3.51062000799e-07 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | Autophagy - animal |
| GO:0048284 | 4.12848417473e-07 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | organelle fusion |
| GO:0061025 | 5.80491386594e-07 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | membrane fusion |
| GO:0007034 | 6.6792565317e-07 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | vacuolar transport |
| KEGG:05132 | 2.16017111801e-06 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | Salmonella infection |
| REAC:R-HSA-9705683 | 3.85680343092e-06 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | SARS-CoV-2-host interactions |
| WP:WP4936 | 6.65532631395e-06 | 0.375 | VPS33A VPS18 VPS39 | Perturbations to host cell autophagy induced by SARS CoV 2 proteins |
| CORUM:944 | 2.39226645298e-05 | 0.25 | VPS18 VPS16 | Class C Vps complex (VPS11, VPS18, VPS16) |
| REAC:R-HSA-9694516 | 2.4954440538e-05 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | SARS-CoV-2 Infection |
| GO:0016050 | 6.49465755701e-05 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | vesicle organization |
| GO:0043254 | 7.69026256593e-05 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | regulation of protein-containing complex assembly |
| WP:WP5115 | 0.000111419692903 | 0.5 | VPS33A VPS18 VPS41 VPS16 | Network map of SARS CoV 2 signaling pathway |
| REAC:R-HSA-9679506 | 0.000122711400125 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | SARS-CoV Infections |
| GO:0005770 | 0.00126773323208 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | late endosome |
| REAC:R-HSA-9824446 | 0.00267983185965 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | Viral Infection Pathways |
| GO:0061024 | 0.00426135925956 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | membrane organization |
| GO:0046907 | 0.00445185102023 | 0.875 | TGFBRAP1 TECPR2 VPS33A VPS18 VPS16 VPS41 VPS39 | intracellular transport |
| REAC:R-HSA-5663205 | 0.00732097255999 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | Infectious disease |
| GO:0044087 | 0.0126066285213 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | regulation of cellular component biogenesis |
| GO:1902501 | 0.0131096201623 | 0.25 | VPS41 VPS39 | lysosomal HOPS complex |
| GO:1902500 | 0.0131096201623 | 0.25 | VPS41 VPS39 | vacuolar HOPS complex |
| GO:0098852 | 0.0141938744355 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | lytic vacuole membrane |
| GO:0005765 | 0.0141938744355 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | lysosomal membrane |
| GO:0005768 | 0.0164390141855 | 0.75 | TGFBRAP1 VPS33A VPS41 VPS39 VPS18 VPS16 | endosome |
| GO:0010008 | 0.0180119984666 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | endosome membrane |
| GO:0005774 | 0.0207850704339 | 0.625 | VPS39 VPS33A VPS18 VPS41 VPS16 | vacuolar membrane |
| GO:0051649 | 0.0250941260125 | 0.875 | TGFBRAP1 TECPR2 VPS33A VPS18 VPS16 VPS41 VPS39 | establishment of localization in cell |
| HP:0002453 | 0.0344311064357 | 0.25 | VPS16 VPS41 | Abnormal globus pallidus morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| VPS11 | TGFBRAP1 | 1.0 | 0.618 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| VPS39 | VPS11 | 1.0 | 0.192 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| VPS18 | TGFBRAP1 | 1.0 | 0.416 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| VPS18 | VPS41 | 1.0 | 0.316 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| VPS41 | VPS11 | 1.0 | 0.128 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| VPS16 | VPS41 | 1.0 | 0.408 |
structurally_consistent (Q9P253)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| VPS16 | VPS33A | 1.0 | 0.962 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| VPS41 | VPS33A | 1.0 | 0.46 |
mutually_exclusive (Q9H269)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| VPS33A | VPS11 | 0.999 | 0.62 |
structurally_consistent (Q8WUH2)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| VPS41 | TGFBRAP1 | 0.999 | 0.076 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| VPS16 | TGFBRAP1 | 0.999 | 0.418 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| VPS18 | VPS16 | 0.999 | 0.94 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| TECPR2 | VPS41 | 0.999 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VPS33A | TGFBRAP1 | 0.999 | 0.424 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| VPS16 | VPS11 | 0.999 | 0.626 |
structurally_consistent (Q9P253)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| VPS18 | VPS11 | 0.998 | 0.52 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| VPS16 | TECPR2 | 0.998 | 0.158 |
mutually_exclusive (Q96AX1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VPS18 | VPS33A | 0.998 | 0.768 | hein_WMM bioplex_WMM bioplex3_WMM hein () fraction | |
| VPS18 | TECPR2 | 0.998 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VPS33A | DNAJB5 | 0.971 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TECPR2 | VPS33A | 0.964 | 0.172 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VPS16 | DNAJB5 | 0.945 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| VPS18 | DNAJB5 | 0.937 | 0.146 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| VPS39 | TGFBRAP1 | 0.937 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only | |
| VPS39 | VPS18 | 0.867 | 0.492 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| VPS41 | DNAJB5 | 0.806 | 0.072 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| VPS39 | VPS33A | 0.74 | 0.342 | bioplex () bioplex_WMM bioplex3_WMM | |
| VPS39 | VPS41 | 0.367 | 0.3 | bioplex3_WMM WMM_only | |
| VPS39 | VPS16 | 0.283 | 0.288 | bioplex3_WMM WMM_only | |
| VPS11 | DNAJB5 | 0.232 | 0.108 | hein_WMM WMM_only | |
| TGFBRAP1 | DNAJB5 | 0.232 | 0.142 | hein_WMM WMM_only | |
| TECPR2 | DNAJB5 | 0.111 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes