hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13853.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MFN2 | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) | 5 | UniProt NCBI |
| TMC1 | Transmembrane channel-like protein 1 (Transmembrane cochlear-expressed protein 1) | 5 | UniProt NCBI |
| MFN1 | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) | 5 | UniProt NCBI |
| UQCC6 | Ubiquinol-cytochrome c reductase complex assembly factor 6 (Protein BRAWNIN) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013419 | 0.000215205765992 | 0.5 | MFN2 MFN1 | RHOT2 GTPase cycle |
| REAC:R-HSA-9715370 | 0.000286914834749 | 0.5 | MFN2 MFN1 | Miro GTPase Cycle |
| REAC:R-HSA-5205685 | 0.00214930898727 | 0.5 | MFN2 MFN1 | PINK1-PRKN Mediated Mitophagy |
| REAC:R-HSA-5205647 | 0.00332479301982 | 0.5 | MFN2 MFN1 | Mitophagy |
| KEGG:04137 | 0.0118173906169 | 0.5 | MFN2 MFN1 | Mitophagy - animal |
| KEGG:04621 | 0.02620193588 | 0.5 | MFN2 MFN1 | NOD-like receptor signaling pathway |
| REAC:R-HSA-9663891 | 0.0282617295192 | 0.5 | MFN2 MFN1 | Selective autophagy |
| HP:0000360 | 0.0476300363671 | 0.5 | MFN2 TMC1 | Tinnitus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MFN1 | MFN2 | 0.994 | 0.286 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TMC1 | MFN1 | 0.971 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UQCC6 | MFN2 | 0.877 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only |
| TMC1 | MFN2 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes