hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13857.1
Complex Portal: CPX-12226
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GPALPP1 | GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7) | 3 | UniProt NCBI |
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
| ZNF786 | Zinc finger protein 786 | 5 | UniProt NCBI |
| AFF3 | AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) | 5 | UniProt NCBI |
| MEX3C | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | 5 | UniProt NCBI |
| PNISR | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | 5 | UniProt NCBI |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | 5 | UniProt NCBI |
| ARL6IP4 | ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4) (HSP-975) (HSVI-binding protein) (SR-15) (SRp25) (SR-25) (Splicing factor SRrp37) | 5 | UniProt NCBI |
| DCUN1D1 | DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) | 5 | UniProt NCBI |
| GRM3 | Metabotropic glutamate receptor 3 (mGluR3) | 5 | UniProt NCBI |
| RTF1 | RNA polymerase-associated protein RTF1 homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 4.59492184186e-07 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | Synthesis of PIPs in the nucleus |
| REAC:R-HSA-6811555 | 9.62706734365e-06 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | PI5P Regulates TP53 Acetylation |
| GO:0016309 | 2.11464090368e-05 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902633 | 2.11464090368e-05 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:1902635 | 2.11464090368e-05 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| REAC:R-HSA-6804758 | 0.000460813413584 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | Regulation of TP53 Activity through Acetylation |
| WP:WP5411 | 0.000557064052793 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | Phosphatidyl inositol phosphate pathway |
| WP:WP4971 | 0.000557064052793 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | Phosphoinositides metabolism |
| KEGG:00562 | 0.000933025920257 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | Inositol phosphate metabolism |
| GO:0016308 | 0.00118146610329 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| REAC:R-HSA-1660499 | 0.00182600441639 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | Synthesis of PIPs at the plasma membrane |
| KEGG:04070 | 0.00209033529143 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | Phosphatidylinositol signaling system |
| REAC:R-HSA-1483255 | 0.00663894567805 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | PI Metabolism |
| REAC:R-HSA-6811558 | 0.00720933666855 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.00945808433372 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | Negative regulation of the PI3K/AKT network |
| GO:2000786 | 0.0142868257683 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | positive regulation of autophagosome assembly |
| WP:WP51 | 0.0159186203537 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | Regulation of actin cytoskeleton |
| HPA:0590053 | 0.0200529631351 | 0.583333333333 | RTF1 GPALPP1 ARL6IP4 AFF3 PNISR PIP4K2C PIP4K2A | thyroid gland; glandular cells[High] |
| KEGG:04810 | 0.0244730917963 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | Regulation of actin cytoskeleton |
| GO:0044090 | 0.0322807659825 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | positive regulation of vacuole organization |
| GO:0052742 | 0.0371057242165 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | phosphatidylinositol kinase activity |
| GO:0046627 | 0.0481447187643 | 0.25 | PIP4K2C PIP4K2A PIP4K2B | negative regulation of insulin receptor signaling pathway |
| CORUM:6371 | 0.0499436884912 | 0.0833333333333 | GRM3 | mGluR3-mGluR8 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 1.0 | 0.014 | |
| PIP4K2A | PIP4K2C | 1.0 | 0.0883043478261 | |
| PIP4K2A | PIP4K2B | 1.0 | 0.318 | |
| PIP4K2A | GPALPP1 | 0.999 | 0.114 | |
| PIP4K2A | PNISR | 0.99 | 0.024 | |
| PIP4K2A | GRM3 | 0.983 | ||
| PIP4K2A | RTF1 | 0.973 | 0.114 | |
| DCUN1D1 | PIP4K2C | 0.969 | 0.072 |
structurally_consistent (dimer)
|
| PIP4K2A | AFF3 | 0.963 | ||
| PIP4K2C | ARL6IP4 | 0.961 | 0.048 | |
| PIP4K2A | MEX3C | 0.96 | 0.106 | |
| GPALPP1 | ZNF786 | 0.908 | ||
| PIP4K2A | ARL6IP4 | 0.895 | 0.04 | |
| GPALPP1 | ARL6IP4 | 0.832 | 0.056 | |
| PIP4K2C | RTF1 | 0.809 | 0.024 | |
| PIP4K2B | ARL6IP4 | 0.787 | 0.042 | |
| PIP4K2B | GPALPP1 | 0.773 | 0.082 | |
| PIP4K2C | GPALPP1 | 0.767 | 0.032 | |
| GRM3 | AFF3 | 0.572 | ||
| GRM3 | MEX3C | 0.572 | ||
| PNISR | GRM3 | 0.502 | ||
| PIP4K2B | DCUN1D1 | 0.343 | 0.054 | |
| PIP4K2A | DCUN1D1 | 0.335 | 0.05 | |
| PIP4K2B | GRM3 | 0.333 | ||
| RTF1 | GRM3 | 0.303 | ||
| AFF3 | MEX3C | 0.303 | ||
| RTF1 | AFF3 | 0.262 | ||
| PIP4K2C | MEX3C | 0.244 | 0.08 | |
| PIP4K2B | AFF3 | 0.213 | ||
| PIP4K2B | MEX3C | 0.213 | 0.098 | |
| PNISR | MEX3C | 0.172 | 0.076 | |
| PNISR | AFF3 | 0.172 | ||
| ARL6IP4 | GRM3 | 0.168 | ||
| RTF1 | MEX3C | 0.164 | 0.138 | |
| RTF1 | ARL6IP4 | 0.149 | 0.116 | |
| PIP4K2C | GRM3 | 0.143 | ||
| GPALPP1 | GRM3 | 0.143 | ||
| GPALPP1 | AFF3 | 0.139 | ||
| GPALPP1 | MEX3C | 0.139 | 0.082 | |
| PIP4K2C | AFF3 | 0.134 | ||
| ARL6IP4 | MEX3C | 0.119 | 0.06 | |
| GPALPP1 | PNISR | 0.11 | 0.148 | |
| RTF1 | PNISR | 0.107 | 0.254 | |
| ARL6IP4 | PNISR | 0.085 | 0.112 | |
| PIP4K2B | PNISR | 0.082 | 0.022 | |
| PIP4K2C | PNISR | 0.075 | 0.054 | |
| ARL6IP4 | AFF3 | 0.054 | ||
| PIP4K2B | RTF1 | 0.05 | 0.03 | |
| GPALPP1 | RTF1 | 0.045 | 0.182 | |
| DCUN1D1 | RTF1 | 0.042 | 0.126 | |
| DCUN1D1 | GPALPP1 | 0.026 | 0.136 | |
| DCUN1D1 | ARL6IP4 | 0.019 | 0.048 |
Related Complexes