hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13860.1
Complex Portal: CPX-19857
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CCSER1 | Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1) | 3 | UniProt NCBI |
| ANKRD26 | Ankyrin repeat domain-containing protein 26 | 5 | UniProt NCBI |
| NDE1 | Nuclear distribution protein nudE homolog 1 (NudE) | 5 | UniProt NCBI |
| FAM124A | Protein FAM124A | 5 | UniProt NCBI |
| SHTN1 | Shootin-1 (Shootin1) | 5 | UniProt NCBI |
| PAFAH1B3 | Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma) | 5 | UniProt NCBI |
| CGNL1 | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | 5 | UniProt NCBI |
| NDEL1 | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | 5 | UniProt NCBI |
| PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | 5 | UniProt NCBI |
| CCSER2 | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | 4 | UniProt NCBI |
| PAFAH1B2 | Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) | 5 | UniProt NCBI |
| DIXDC1 | Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5409 | 6.37387064498e-09 | 0.333333333333 | PAFAH1B2 PAFAH1B3 PAFAH1B1 NDEL1 | PAFAH1B1 copy number variation |
| GO:0008247 | 2.11464090368e-05 | 0.25 | PAFAH1B3 PAFAH1B1 PAFAH1B2 | 1-alkyl-2-acetylglycerophosphocholine esterase complex |
| KEGG:00565 | 0.000168134627057 | 0.25 | PAFAH1B3 PAFAH1B1 PAFAH1B2 | Ether lipid metabolism |
| REAC:R-HSA-6811436 | 0.00220413551192 | 0.25 | PAFAH1B3 PAFAH1B1 PAFAH1B2 | COPI-independent Golgi-to-ER retrograde traffic |
| WP:WP5376 | 0.0136056357253 | 0.166666666667 | NDEL1 PAFAH1B1 | 17p13 3 YWHAE copy number variation |
| REAC:R-HSA-141444 | 0.0138503617857 | 0.25 | NDE1 PAFAH1B1 NDEL1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.0138503617857 | 0.25 | NDE1 PAFAH1B1 NDEL1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-69618 | 0.0223503721045 | 0.25 | NDE1 PAFAH1B1 NDEL1 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.0255731910989 | 0.25 | NDE1 PAFAH1B1 NDEL1 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2500257 | 0.0313378649398 | 0.25 | NDE1 PAFAH1B1 NDEL1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 0.0353388071054 | 0.25 | PAFAH1B3 PAFAH1B1 PAFAH1B2 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 0.0405630540002 | 0.25 | NDE1 PAFAH1B1 NDEL1 | RHO GTPases Activate Formins |
| GO:0030010 | 0.0489656241057 | 0.333333333333 | NDE1 SHTN1 PAFAH1B1 NDEL1 | establishment of cell polarity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| PAFAH1B3 | PAFAH1B2 | 1.0 | 0.406 |
structurally_consistent (dimer)
|
| NDEL1 | DIXDC1 | 1.0 | 0.094 |
structurally_consistent (dimer)
|
| CCSER1 | NDEL1 | 1.0 |
structurally_consistent (dimer)
|
|
| NDEL1 | CCSER2 | 1.0 | 0.122 |
structurally_consistent (dimer)
|
| NDE1 | NDEL1 | 0.999 |
structurally_consistent (dimer)
|
|
| CCSER1 | NDE1 | 0.999 |
mutually_exclusive (Q9GZM8)
structurally_consistent (dimer) |
|
| PAFAH1B1 | PAFAH1B3 | 0.999 | 0.048 |
structurally_consistent (P68402)
structurally_consistent (dimer) |
| PAFAH1B1 | PAFAH1B2 | 0.997 | 0.52 |
structurally_consistent (dimer)
|
| NDEL1 | PAFAH1B1 | 0.996 | 0.266 |
structurally_consistent (dimer)
|
| NDE1 | CCSER2 | 0.994 | ||
| NDE1 | DIXDC1 | 0.991 | ||
| NDE1 | PAFAH1B1 | 0.985 |
structurally_consistent (dimer)
|
|
| CCSER2 | PAFAH1B1 | 0.982 | 0.0977 | |
| CCSER2 | ANKRD26 | 0.969 | 0.108 | |
| DIXDC1 | PAFAH1B1 | 0.961 | 0.1 | |
| PAFAH1B1 | SHTN1 | 0.951 | 0.086 | |
| DIXDC1 | FAM124A | 0.94 | 0.048 | |
| NDEL1 | SHTN1 | 0.925 | 0.102 | |
| CCSER2 | DIXDC1 | 0.902 | 0.108 | |
| CCSER1 | PAFAH1B1 | 0.893 | ||
| CCSER1 | CCSER2 | 0.885 |
mutually_exclusive (Q9GZM8)
|
|
| NDE1 | CGNL1 | 0.869 | ||
| NDEL1 | ANKRD26 | 0.845 | 0.158 | |
| CCSER1 | DIXDC1 | 0.735 | ||
| NDE1 | SHTN1 | 0.497 | ||
| NDEL1 | PAFAH1B3 | 0.354 | 0.102 |
mutually_exclusive (P43034)
|
| CCSER2 | CGNL1 | 0.331 | 0.058 | |
| DIXDC1 | SHTN1 | 0.22 | 0.098 | |
| CCSER1 | SHTN1 | 0.201 | ||
| CCSER2 | PAFAH1B2 | 0.192 | 0.076 | |
| CCSER2 | PAFAH1B3 | 0.192 | 0.048 | |
| NDE1 | FAM124A | 0.182 | ||
| CCSER2 | SHTN1 | 0.17 | 0.1 | |
| CCSER1 | ANKRD26 | 0.164 | ||
| DIXDC1 | ANKRD26 | 0.164 | 0.196 | |
| DIXDC1 | PAFAH1B2 | 0.063 | 0.04 | |
| DIXDC1 | PAFAH1B3 | 0.063 | 0.06 | |
| NDEL1 | PAFAH1B2 | 0.062 | 0.312 |
mutually_exclusive (P43034)
structurally_consistent (dimer) |
| NDE1 | PAFAH1B2 | 0.056 |
mutually_exclusive (P43034)
|
|
| NDE1 | ANKRD26 | 0.047 | ||
| ANKRD26 | PAFAH1B1 | 0.044 | 0.134 | |
| NDEL1 | FAM124A | 0.043 | 0.156 | |
| NDE1 | PAFAH1B3 | 0.043 |
mutually_exclusive (P43034)
|
|
| NDEL1 | CGNL1 | 0.032 | 0.084 | |
| ANKRD26 | CGNL1 | 0.032 | 0.174 | |
| ANKRD26 | SHTN1 | 0.016 | 0.12 | |
| ANKRD26 | PAFAH1B3 | 0.014 | 0.132 | |
| PAFAH1B2 | SHTN1 | 0.008 | 0.076 | |
| SHTN1 | CGNL1 | 0.006 | 0.05 | |
| PAFAH1B3 | SHTN1 | 0.005 | 0.084 |
Related Complexes