hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13863.1
Complex Portal: CPX-14342
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SIVA1 | Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP) | 5 | UniProt NCBI |
| RPE65 | Retinoid isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl-palmitate hydrolase) (Lutein isomerase) (Meso-zeaxanthin isomerase) (EC 5.3.3.22) (Retinal pigment epithelium-specific 65 kDa protein) (Retinol isomerase) | 5 | UniProt NCBI |
| CCNB3 | G2/mitotic-specific cyclin-B3 | 5 | UniProt NCBI |
| E2F5 | Transcription factor E2F5 (E2F-5) | 5 | UniProt NCBI |
| CDK14 | Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1) | 5 | UniProt NCBI |
| CCNO | Cyclin-O | 5 | UniProt NCBI |
| FGR | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | 5 | UniProt NCBI |
| CDKN1A | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000307 | 0.00062119716087 | 0.5 | CCNB3 CDKN1A CCNO CDK14 | cyclin-dependent protein kinase holoenzyme complex |
| KEGG:04218 | 0.00230271739071 | 0.375 | CCNB3 E2F5 CDKN1A | Cellular senescence |
| WP:WP179 | 0.00241828824912 | 0.375 | CCNB3 E2F5 CDKN1A | Cell cycle |
| KEGG:04110 | 0.00288562872481 | 0.375 | CCNB3 E2F5 CDKN1A | Cell cycle |
| GO:1902554 | 0.0179481315058 | 0.5 | CCNB3 CDKN1A CCNO CDK14 | serine/threonine protein kinase complex |
| KEGG:04115 | 0.0257266913769 | 0.25 | SIVA1 CDKN1A | p53 signaling pathway |
| GO:1902911 | 0.0298370680549 | 0.5 | CCNB3 CDKN1A CCNO CDK14 | protein kinase complex |
| WP:WP1530 | 0.0489078463283 | 0.25 | CCNB3 CDKN1A | miRNA regulation of DNA damage response |
| WP:WP707 | 0.0489078463283 | 0.25 | CCNB3 CDKN1A | DNA damage response |
| CORUM:314 | 0.0499436884912 | 0.125 | CDKN1A | PCNA-p21 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FGR | RPE65 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CCNO | CDKN1A | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CCNB3 | CDKN1A | 0.991 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CDKN1A | CDK14 | 0.984 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| E2F5 | CDKN1A | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FGR | CDKN1A | 0.981 | 0.138 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FGR | CDK14 | 0.919 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SIVA1 | CDKN1A | 0.911 |
mutually_exclusive (P12004)
|
hein_WMM bioplex3_WMM WMM_only | |
| CCNO | CCNB3 | 0.902 | bioplex3_WMM WMM_only | ||
| E2F5 | CCNB3 | 0.892 | bioplex3_WMM WMM_only | ||
| CCNO | E2F5 | 0.892 | bioplex3_WMM WMM_only | ||
| FGR | CCNB3 | 0.869 | bioplex3_WMM WMM_only | ||
| CCNO | FGR | 0.869 | bioplex3_WMM WMM_only | ||
| FGR | E2F5 | 0.356 | bioplex3_WMM WMM_only | ||
| CCNO | CDK14 | 0.108 | bioplex3_WMM WMM_only | ||
| CCNB3 | CDK14 | 0.079 | bioplex3_WMM WMM_only | ||
| E2F5 | CDK14 | 0.042 | bioplex3_WMM WMM_only |
Related Complexes